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This issue of Neurologic Clinics features a review of the latest therapeutic developments in common and less common neurologic disorders and includes the following articles: Latest Data on Platelet Antiaggregants in Stroke Prevention; New Anticoagulants for Atrial Fibrillation Stroke Prevention; Unanswered Questions in Thrombolytic Therapy for Acute Ischemic Stroke; New Strategies for Endovascular Recanalization of Acute Ischemic Stroke; New Developments in the Treatment of Intracerebral Hemorrhage. What is in the horizon?; New Therapies for Unruptured Intracranial Aneurysms; New and Emergency Therapies for Arteriovenous Malformations; Advances and Controversies in the Management of Cerebral Venous Thrombosis in Adults; Epilepsy: Neurostimulation and New Drug Targets; Surgical Treatment of Parkinson's Disease; Deep Brain Stimulation (DBS) in Non-Parkinsonian Movement Disorders and Emerging Technologies, Targets and Therapeutic Promises in DBS; Multiple Sclerosis. New and Emerging Therapies; Advances in the Medical Management of Myasthenia Gravis; Update in the Treatment of Primary Brain Tumors; and Immunotherapy for Alzheimer’s Disease.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 7 6. Preface - p. 8 7. Platelet Antiaggregants in Stroke Prevention - p. 9 8. New Anticoagulants (Dabigatran, Apixaban, Rivaroxaban) for Stroke Prevention in Atrial Fibrillation - p. 20 9. Unanswered Questions in Thrombolytic Therapy for Acute Ischemic Stroke - p. 27 10. New Strategies for Endovascular Recanalization of Acute Ischemic Stroke - p. 43 11. New Developments in the Treatment of Intracerebral Hemorrhage - p. 48 12. New Therapies for Unruptured Intracranial Aneurysms - p. 55 13. The Diagnosis and Management of Brain Arteriovenous Malformations - p. 60 14. Advances and Controversies in the Management of Cerebral Venous Thrombosis - p. 67 15. Epilepsy - p. 77 16. Surgical Treatment of Parkinson Disease - p. 82 17. Deep Brain Stimulation in Nonparkinsonian Movement Disorders and Emerging Technologies, Targets, and Therapeutic Promises in Deep Brain Stimulation - p. 87 18. Update on Therapeutic Options for Multiple Sclerosis - p. 98 19. Update in the Treatment of High-grade Gliomas - p. 110 20. Immunotherapy for Alzheimer’s Disease - p. 123 21. Index - p. 129

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This issue of Neurologic Clinics features a review of the latest therapeutic developments in common and less common neurologic disorders and includes the following articles: Latest Data on Platelet Antiaggregants in Stroke Prevention; New Anticoagulants for Atrial Fibrillation Stroke Prevention; Unanswered Questions in Thrombolytic Therapy for Acute Ischemic Stroke; New Strategies for Endovascular Recanalization of Acute Ischemic Stroke; New Developments in the Treatment of Intracerebral Hemorrhage. What is in the horizon?; New Therapies for Unruptured Intracranial Aneurysms; New and Emergency Therapies for Arteriovenous Malformations; Advances and Controversies in the Management of Cerebral Venous Thrombosis in Adults; Epilepsy: Neurostimulation and New Drug Targets; Surgical Treatment of Parkinson's Disease; Deep Brain Stimulation (DBS) in Non-Parkinsonian Movement Disorders and Emerging Technologies, Targets and Therapeutic Promises in DBS; Multiple Sclerosis. New and Emerging Therapies; Advances in the Medical Management of Myasthenia Gravis; Update in the Treatment of Primary Brain Tumors; and Immunotherapy for Alzheimer’s Disease.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 7 6. Preface - p. 8 7. Platelet Antiaggregants in Stroke Prevention - p. 9 8. New Anticoagulants (Dabigatran, Apixaban, Rivaroxaban) for Stroke Prevention in Atrial Fibrillation - p. 20 9. Unanswered Questions in Thrombolytic Therapy for Acute Ischemic Stroke - p. 27 10. New Strategies for Endovascular Recanalization of Acute Ischemic Stroke - p. 43 11. New Developments in the Treatment of Intracerebral Hemorrhage - p. 48 12. New Therapies for Unruptured Intracranial Aneurysms - p. 55 13. The Diagnosis and Management of Brain Arteriovenous Malformations - p. 60 14. Advances and Controversies in the Management of Cerebral Venous Thrombosis - p. 67 15. Epilepsy - p. 77 16. Surgical Treatment of Parkinson Disease - p. 82 17. Deep Brain Stimulation in Nonparkinsonian Movement Disorders and Emerging Technologies, Targets, and Therapeutic Promises in Deep Brain Stimulation - p. 87 18. Update on Therapeutic Options for Multiple Sclerosis - p. 98 19. Update in the Treatment of High-grade Gliomas - p. 110 20. Immunotherapy for Alzheimer’s Disease - p. 123 21. Index - p. 129

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