Part of the highly regarded Biopsy Interpretation Series, this new volume by Drs. Laura M. Wake, Genevieve Crane, and Michael Borowitz presents a concise, pattern-based approach to bone marrow pathology. Biopsy Interpretation of the Bone Marrow provides superbly illustrated guidance from top experts in the field, covering all aspects of bone marrow aspirates and biopsies: procurement and processing, ancillary techniques, formulation of a final diagnosis, and reporting to the clinical team. Hundreds of full-color illustrations depict the full range of benign and neoplastic processes involving the bone marrow.
1. Cover - p. Cover 2. Title Page - p. i 3. Copyright - p. iv 4. Dedication - p. v 5. Preface - p. vii 6. Contents - p. ix 7. 1 Peripheral Blood Findings and the Indications for a Bone Marrow Examination - p. 1 8. ANALYSIS OF CELLULAR ELEMENTS IN THE PB - p. 2 9. GOLDEN ZONE - p. 2 10. RED BLOOD CELLS - p. 2 11. WHITE BLOOD CELLS - p. 9 12. GRANULOCYTES - p. 12 13. MONOCYTES - p. 18 14. LYMPHOCYTES - p. 18 15. PLATELETS - p. 25 16. OTHER CELLS AND OBJECTS IDENTIFIED IN THE PB - p. 27 17. Chapter 1: Interactive MCQ - p. 28 18. 2 Bone Marrow Biopsy Procedure and Evaluation - p. 29 19. BONE MARROW BIOPSY AND ASPIRATE PROCEDURE - p. 29 20. ASSESSING ADEQUACY OF BM SAMPLES - p. 30 21. CELLULARITY - p. 36 22. ORGANIZATION OF THE BM AND NORMAL HEMATOPOIESIS - p. 37 23. MYELOID CELLS - p. 38 24. MONOCYTIC CELLS - p. 42 25. ERYTHROID CELLS - p. 42 26. MEGAKARYOCYTES - p. 46 27. LYMPHOCYTES - p. 46 28. OTHER CELLS AND NORMAL BM CONSTITUENTS - p. 51 29. STAINS - p. 54 30. Chapter 2: Interactive MCQ - p. 59 31. 3 Ancillary Studies - p. 60 32. FLOW CYTOMETRY - p. 60 33. IMMUNOHISTOCHEMISTRY - p. 70 34. CONVENTIONAL CYTOGENETICS/KARYOTYPE - p. 76 35. FLORESCENCE IN SITU HYBRIDIZATION - p. 79 36. MOLECULAR STUDIES - p. 84 37. NEXT-GENERATION SEQUENCING - p. 90 38. FUTURE APPROACHES - p. 93 39. CONCLUSION - p. 93 40. Chapter 3: Interactive MCQ - p. 95 41. 4 Acute Myeloid Leukemia - p. 96 42. DIAGNOSIS - p. 96 43. AML CLASSIFICATION - p. 96 44. EPIDEMIOLOGY AND CLINICAL PRESENTATION - p. 96 45. MORPHOLOGY - p. 98 46. PHENOTYPE - p. 101 47. BLAST IDENTIFICATION BY FC - p. 105 48. GENETICS - p. 110 49. SUBCLASSIFICATION OF AML - p. 111 50. AML WITH RECURRENT TRANSLOCATIONS - p. 111 51. OTHER ENTITIES - p. 123 52. SUBTYPES OF AML WITH UNIQUE GENE MUTATIONS - p. 128 53. OTHER GENE MUTATIONS IN AML - p. 130 54. MYELOID NEOPLASMS ASSOCIATED WITH DOWN SYNDROME - p. 131 55. Chapter 4: Interactive MCQ - p. 143 56. 5 Myelodysplastic Syndrome (Mds) and Myelodysplastic Syndrome/Myeloproliferative Neoplasm (Mds/Mpn) - p. 144 57. MYELODYSPLASTIC SYNDROME/MYELODYSPLASTIC NEOPLASM - p. 144 58. MYELOID NEOPLASM (MDS/MPN) OVERLAP SYNDROMES - p. 172 59. Chapter 5: Interactive MCQ - p. 192 60. 6 Myeloproliferative Neoplasms (Mpns), Neoplasms Associated wWith Eosinophilia and Gene Rearrangements, and Mastocytosis - p. 193 61. CLINICAL - p. 196 62. MORPHOLOGIC FEATURES - p. 197 63. IMMUNOPHENOTYPE - p. 198 64. GENETICS - p. 203 65. PROGNOSIS - p. 204 66. CHRONIC MYELOID LEUKEMIA, BCR::ABL1-POSITIVE - p. 204 67. BCR::ABL1-NEGATIVE MPNs - p. 215 68. POLYCYTHEMIA VERA - p. 216 69. THE PROLIFERATIVE POLYCYTHEMIC STAGE - p. 217 70. PRIMARY MYELOFIBROSIS - p. 220 71. ESSENTIAL THROMBOCYTHEMIA - p. 224 72. CHRONIC NEUTROPHILIC LEUKEMIA - p. 228 73. CHRONIC EOSINOPHILIC LEUKEMIA, NOT OTHERWISE SPECIFIED - p. 230 74. IDIOPATHIC HYPEREOSINOPHILIA/IDIOPATHIC HYPEREOSINOPHILIC SYNDROME - p. 232 75. MYELOPROLIFERATIVE NEOPLASM, UNCLASSIFIABLE - p. 232 76. MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND TK GENE FUSIONS - p. 233 77. MASTOCYTOSIS - p. 234 78. Chapter 6: Interactive MCQ - p. 246 79. 7 Acute Lymphoblastic Leukemia/Lymphoma (All) and Other Acute Leukemias - p. 247 80. B-ACUTE LYMPHOBLASTIC LEUKEMIA - p. 247 81. SUBCLASSIFICATION OF B-ALL - p. 255 82. OTHER SUBTYPES - p. 260 83. LEUKEMIAS OF AMBIGUOUS LINEAGES - p. 263 84. BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM - p. 267 85. Chapter 7: Interactive MCQ - p. 275 86. 8 Mature Lymphoid Leukemias/Lymphomas - p. 277 87. Presentation - p. 277 88. BM BIOPSY - p. 278 89. B CELL LYMPHOMAS WITH PREDOMINANTLY NODULAR PATTERNS OF INFILTRATION - p. 280 90. CLL/SLL AND MONOCLONAL B CELL LYMPHOCYTOSIS - p. 282 91. MONOCLONAL B CELL LYMPHOCYTOSIS - p. 287 92. MANTLE CELL LYMPHOMA/LEUKEMIA - p. 287 93. FOLLICULAR LYMPHOMA - p. 291 94. REVIEW OF THE DIFFERENTIAL DIAGNOSIS OF NODULAR LYMPHOID AGGREGATES OF SMALL MATURE LYMPHOID CELLS - p. 296 95. B CELL LYMPHOMAS WITH PREDOMINANTLY DIFFUSE OR INTERSTITIAL PATTERNS OF INFILTRATION - p. 297 96. HAIRY CELL LEUKEMIA - p. 297 97. BURKITT LYMPHOMA/LEUKEMIA - p. 302 98. DIFFUSE LARGE B CELL LYMPHOMA - p. 306 99. REVIEW OF INTERSTITIAL OR DIFFUSE B CELL INFILTRATES - p. 309 100. B CELL LYMPHOMAS WITH MIXED OR OTHER PATTERNS OF INFILTRATION - p. 311 101. SPLENIC MARGINAL ZONE LYMPHOMA - p. 312 102. LYMPHOPLASMACYTIC LYMPHOMA (LPL) - p. 315 103. REVIEW OF MIXED OR OTHER INFILTRATION PATTERNS - p. 319 104. SINGLE CELL B CELL INFILTRATION IN AN INFLAMMATORY BACKGROUND - p. 320 105. T CELL HISTIOCYTE-RICH LARGE B CELL LYMPHOMA - p. 320 106. CLASSIC HODGKIN LYMPHOMA - p. 323 107. REVIEW OF SINGLE CELL INFILTRATIONS - p. 326 108. Mature T cell Lymphomas/Leukemias - p. 326 109. T cell LYMPHOMAS WITH INVARIABLE OR HIGH-FREQUENCY BM INVOLVEMENT - p. 328 110. PERIPHERAL T CELL LYMPHOMAS WITH SECONDARY BM INVOLVEMENT - p. 339 111. OTHER T cell LYMPHOMAS - p. 342 112. REVIEW OF MATURE T cell LEUKEMIA/LYMPHOMA BM INVOLVEMENT - p. 342 113. Chapter 8: Interactive MCQ - p. 343 114. 9 Plasma Cell Disorders - p. 344 115. PLASMA CELL NEOPLASMS - p. 345 116. MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE - p. 359 117. PLASMA CELL MYELOMA - p. 360 118. RARE PCM SUBTYPES - p. 366 119. Chapter 9: Interactive MCQ - p. 367 120. 10 Abnormalities of Bone and Stroma, Infections, and Other Nonhematolymphoid Disorders - p. 368 121. ABNORMALITIES OF BONE - p. 368 122. STROMA - p. 372 123. INFECTIOUS ORGANISMS - p. 388 124. OTHER INFECTIOUS ORGANISMS - p. 390 125. OTHER DISORDERS - p. 392 126. METASTATIC CARCINOMA - p. 393 127. PEDIATRIC PATIENTS - p. 394 128. ADULT PATIENTS - p. 395 129. Chapter 10: Interactive MCQ - p. 398 130. Index - p. 399
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Part of the highly regarded Biopsy Interpretation Series, this new volume by Drs. Laura M. Wake, Genevieve Crane, and Michael Borowitz presents a concise, pattern-based approach to bone marrow pathology. Biopsy Interpretation of the Bone Marrow provides superbly illustrated guidance from top experts in the field, covering all aspects of bone marrow aspirates and biopsies: procurement and processing, ancillary techniques, formulation of a final diagnosis, and reporting to the clinical team. Hundreds of full-color illustrations depict the full range of benign and neoplastic processes involving the bone marrow.
1. Cover - p. Cover 2. Title Page - p. i 3. Copyright - p. iv 4. Dedication - p. v 5. Preface - p. vii 6. Contents - p. ix 7. 1 Peripheral Blood Findings and the Indications for a Bone Marrow Examination - p. 1 8. ANALYSIS OF CELLULAR ELEMENTS IN THE PB - p. 2 9. GOLDEN ZONE - p. 2 10. RED BLOOD CELLS - p. 2 11. WHITE BLOOD CELLS - p. 9 12. GRANULOCYTES - p. 12 13. MONOCYTES - p. 18 14. LYMPHOCYTES - p. 18 15. PLATELETS - p. 25 16. OTHER CELLS AND OBJECTS IDENTIFIED IN THE PB - p. 27 17. Chapter 1: Interactive MCQ - p. 28 18. 2 Bone Marrow Biopsy Procedure and Evaluation - p. 29 19. BONE MARROW BIOPSY AND ASPIRATE PROCEDURE - p. 29 20. ASSESSING ADEQUACY OF BM SAMPLES - p. 30 21. CELLULARITY - p. 36 22. ORGANIZATION OF THE BM AND NORMAL HEMATOPOIESIS - p. 37 23. MYELOID CELLS - p. 38 24. MONOCYTIC CELLS - p. 42 25. ERYTHROID CELLS - p. 42 26. MEGAKARYOCYTES - p. 46 27. LYMPHOCYTES - p. 46 28. OTHER CELLS AND NORMAL BM CONSTITUENTS - p. 51 29. STAINS - p. 54 30. Chapter 2: Interactive MCQ - p. 59 31. 3 Ancillary Studies - p. 60 32. FLOW CYTOMETRY - p. 60 33. IMMUNOHISTOCHEMISTRY - p. 70 34. CONVENTIONAL CYTOGENETICS/KARYOTYPE - p. 76 35. FLORESCENCE IN SITU HYBRIDIZATION - p. 79 36. MOLECULAR STUDIES - p. 84 37. NEXT-GENERATION SEQUENCING - p. 90 38. FUTURE APPROACHES - p. 93 39. CONCLUSION - p. 93 40. Chapter 3: Interactive MCQ - p. 95 41. 4 Acute Myeloid Leukemia - p. 96 42. DIAGNOSIS - p. 96 43. AML CLASSIFICATION - p. 96 44. EPIDEMIOLOGY AND CLINICAL PRESENTATION - p. 96 45. MORPHOLOGY - p. 98 46. PHENOTYPE - p. 101 47. BLAST IDENTIFICATION BY FC - p. 105 48. GENETICS - p. 110 49. SUBCLASSIFICATION OF AML - p. 111 50. AML WITH RECURRENT TRANSLOCATIONS - p. 111 51. OTHER ENTITIES - p. 123 52. SUBTYPES OF AML WITH UNIQUE GENE MUTATIONS - p. 128 53. OTHER GENE MUTATIONS IN AML - p. 130 54. MYELOID NEOPLASMS ASSOCIATED WITH DOWN SYNDROME - p. 131 55. Chapter 4: Interactive MCQ - p. 143 56. 5 Myelodysplastic Syndrome (Mds) and Myelodysplastic Syndrome/Myeloproliferative Neoplasm (Mds/Mpn) - p. 144 57. MYELODYSPLASTIC SYNDROME/MYELODYSPLASTIC NEOPLASM - p. 144 58. MYELOID NEOPLASM (MDS/MPN) OVERLAP SYNDROMES - p. 172 59. Chapter 5: Interactive MCQ - p. 192 60. 6 Myeloproliferative Neoplasms (Mpns), Neoplasms Associated wWith Eosinophilia and Gene Rearrangements, and Mastocytosis - p. 193 61. CLINICAL - p. 196 62. MORPHOLOGIC FEATURES - p. 197 63. IMMUNOPHENOTYPE - p. 198 64. GENETICS - p. 203 65. PROGNOSIS - p. 204 66. CHRONIC MYELOID LEUKEMIA, BCR::ABL1-POSITIVE - p. 204 67. BCR::ABL1-NEGATIVE MPNs - p. 215 68. POLYCYTHEMIA VERA - p. 216 69. THE PROLIFERATIVE POLYCYTHEMIC STAGE - p. 217 70. PRIMARY MYELOFIBROSIS - p. 220 71. ESSENTIAL THROMBOCYTHEMIA - p. 224 72. CHRONIC NEUTROPHILIC LEUKEMIA - p. 228 73. CHRONIC EOSINOPHILIC LEUKEMIA, NOT OTHERWISE SPECIFIED - p. 230 74. IDIOPATHIC HYPEREOSINOPHILIA/IDIOPATHIC HYPEREOSINOPHILIC SYNDROME - p. 232 75. MYELOPROLIFERATIVE NEOPLASM, UNCLASSIFIABLE - p. 232 76. MYELOID/LYMPHOID NEOPLASMS WITH EOSINOPHILIA AND TK GENE FUSIONS - p. 233 77. MASTOCYTOSIS - p. 234 78. Chapter 6: Interactive MCQ - p. 246 79. 7 Acute Lymphoblastic Leukemia/Lymphoma (All) and Other Acute Leukemias - p. 247 80. B-ACUTE LYMPHOBLASTIC LEUKEMIA - p. 247 81. SUBCLASSIFICATION OF B-ALL - p. 255 82. OTHER SUBTYPES - p. 260 83. LEUKEMIAS OF AMBIGUOUS LINEAGES - p. 263 84. BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM - p. 267 85. Chapter 7: Interactive MCQ - p. 275 86. 8 Mature Lymphoid Leukemias/Lymphomas - p. 277 87. Presentation - p. 277 88. BM BIOPSY - p. 278 89. B CELL LYMPHOMAS WITH PREDOMINANTLY NODULAR PATTERNS OF INFILTRATION - p. 280 90. CLL/SLL AND MONOCLONAL B CELL LYMPHOCYTOSIS - p. 282 91. MONOCLONAL B CELL LYMPHOCYTOSIS - p. 287 92. MANTLE CELL LYMPHOMA/LEUKEMIA - p. 287 93. FOLLICULAR LYMPHOMA - p. 291 94. REVIEW OF THE DIFFERENTIAL DIAGNOSIS OF NODULAR LYMPHOID AGGREGATES OF SMALL MATURE LYMPHOID CELLS - p. 296 95. B CELL LYMPHOMAS WITH PREDOMINANTLY DIFFUSE OR INTERSTITIAL PATTERNS OF INFILTRATION - p. 297 96. HAIRY CELL LEUKEMIA - p. 297 97. BURKITT LYMPHOMA/LEUKEMIA - p. 302 98. DIFFUSE LARGE B CELL LYMPHOMA - p. 306 99. REVIEW OF INTERSTITIAL OR DIFFUSE B CELL INFILTRATES - p. 309 100. B CELL LYMPHOMAS WITH MIXED OR OTHER PATTERNS OF INFILTRATION - p. 311 101. SPLENIC MARGINAL ZONE LYMPHOMA - p. 312 102. LYMPHOPLASMACYTIC LYMPHOMA (LPL) - p. 315 103. REVIEW OF MIXED OR OTHER INFILTRATION PATTERNS - p. 319 104. SINGLE CELL B CELL INFILTRATION IN AN INFLAMMATORY BACKGROUND - p. 320 105. T CELL HISTIOCYTE-RICH LARGE B CELL LYMPHOMA - p. 320 106. CLASSIC HODGKIN LYMPHOMA - p. 323 107. REVIEW OF SINGLE CELL INFILTRATIONS - p. 326 108. Mature T cell Lymphomas/Leukemias - p. 326 109. T cell LYMPHOMAS WITH INVARIABLE OR HIGH-FREQUENCY BM INVOLVEMENT - p. 328 110. PERIPHERAL T CELL LYMPHOMAS WITH SECONDARY BM INVOLVEMENT - p. 339 111. OTHER T cell LYMPHOMAS - p. 342 112. REVIEW OF MATURE T cell LEUKEMIA/LYMPHOMA BM INVOLVEMENT - p. 342 113. Chapter 8: Interactive MCQ - p. 343 114. 9 Plasma Cell Disorders - p. 344 115. PLASMA CELL NEOPLASMS - p. 345 116. MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE - p. 359 117. PLASMA CELL MYELOMA - p. 360 118. RARE PCM SUBTYPES - p. 366 119. Chapter 9: Interactive MCQ - p. 367 120. 10 Abnormalities of Bone and Stroma, Infections, and Other Nonhematolymphoid Disorders - p. 368 121. ABNORMALITIES OF BONE - p. 368 122. STROMA - p. 372 123. INFECTIOUS ORGANISMS - p. 388 124. OTHER INFECTIOUS ORGANISMS - p. 390 125. OTHER DISORDERS - p. 392 126. METASTATIC CARCINOMA - p. 393 127. PEDIATRIC PATIENTS - p. 394 128. ADULT PATIENTS - p. 395 129. Chapter 10: Interactive MCQ - p. 398 130. Index - p. 399
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