Dr. Loftus is a widely recognized expert in the diagnosis and treatment of Crohn's disease. He has created an issue devoted the current state-of-the-art on Crohn's disease; authors have written comprehensive reviews on the latest research to inform clinical diagnosis and treatment. Articles are devoted to the following topics: Genetics; Epidemiology, natural history, and risk stratification of Crohn’s disease; The microbiome in Crohn’s disease: Role in pathogenesis and role of microbiome replacement therapies; Endoscopic and radiographic assessment of Crohn’s disease; Intestinal and non-intestinal cancer risk in Crohn’s disease; Sexuality, fertility, and pregnancy in Crohn’s disease; Interdisciplinary management of perianal Crohn’s disease; Targeting specific immunologic pathways in human inflammatory bowel disease; Evolution of treatment paradigms in Crohn’s disease; Preventing and managing postoperative recurrence of Crohn’s disease; Where and how to use anti-TNF agents and anti-integrins in Crohn’s disease; Ustekinumab and anti-interleukin-23 agents in Crohn’s disease; Update on therapeutic drug monitoring in Crohn’s disease; and Janus kinase antagonists and other novel small molecules for the treatment of Crohn’s disease. Readers will come away from this issue armed with the information they need to improve management of this disease as well as patient outcomes.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Preface - p. xiii 8. Crohn's Disease: Genetics Update - p. 449 9. Epidemiology, Natural History, and Risk Stratification of Crohn's Disease - p. 463 10. The Microbiome in Crohn's Disease: Role in Pathogenesis and Role of Microbiome Replacement Therapies - p. 481 11. Endoscopic and Radiographic Assessment of Crohn's Disease - p. 493 12. Intestinal and Nonintestinal Cancer Risks for Patients with Crohn's Disease - p. 515 13. Sexuality, Fertility, and Pregnancy in Crohn's Disease - p. 531 14. Interdisciplinary Management of Perianal Crohn's Disease - p. 547 15. Management of Crohn's Disease After Surgical Resection - p. 563 16. Targeting Specific Immunologic Pathways in Crohn's Disease - p. 577 17. Use of Anti–Tumor Necrosis Factors and Anti-Integrins in the Treatment of Crohn's Disease - p. 589 18. Ustekinumab and Anti-Interleukin-23 Agents in Crohn's Disease - p. 603 19. Janus Kinase Antagonists and Other Novel Small Molecules for the Treatment of Crohn's Disease - p. 627 20. Update on Therapeutic Drug Monitoring in Crohn's Disease - p. 645 21. The Evolution of Treatment Paradigms in Crohn's Disease: Beyond Better Drugs - p. 661
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Dr. Loftus is a widely recognized expert in the diagnosis and treatment of Crohn's disease. He has created an issue devoted the current state-of-the-art on Crohn's disease; authors have written comprehensive reviews on the latest research to inform clinical diagnosis and treatment. Articles are devoted to the following topics: Genetics; Epidemiology, natural history, and risk stratification of Crohn’s disease; The microbiome in Crohn’s disease: Role in pathogenesis and role of microbiome replacement therapies; Endoscopic and radiographic assessment of Crohn’s disease; Intestinal and non-intestinal cancer risk in Crohn’s disease; Sexuality, fertility, and pregnancy in Crohn’s disease; Interdisciplinary management of perianal Crohn’s disease; Targeting specific immunologic pathways in human inflammatory bowel disease; Evolution of treatment paradigms in Crohn’s disease; Preventing and managing postoperative recurrence of Crohn’s disease; Where and how to use anti-TNF agents and anti-integrins in Crohn’s disease; Ustekinumab and anti-interleukin-23 agents in Crohn’s disease; Update on therapeutic drug monitoring in Crohn’s disease; and Janus kinase antagonists and other novel small molecules for the treatment of Crohn’s disease. Readers will come away from this issue armed with the information they need to improve management of this disease as well as patient outcomes.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Preface - p. xiii 8. Crohn's Disease: Genetics Update - p. 449 9. Epidemiology, Natural History, and Risk Stratification of Crohn's Disease - p. 463 10. The Microbiome in Crohn's Disease: Role in Pathogenesis and Role of Microbiome Replacement Therapies - p. 481 11. Endoscopic and Radiographic Assessment of Crohn's Disease - p. 493 12. Intestinal and Nonintestinal Cancer Risks for Patients with Crohn's Disease - p. 515 13. Sexuality, Fertility, and Pregnancy in Crohn's Disease - p. 531 14. Interdisciplinary Management of Perianal Crohn's Disease - p. 547 15. Management of Crohn's Disease After Surgical Resection - p. 563 16. Targeting Specific Immunologic Pathways in Crohn's Disease - p. 577 17. Use of Anti–Tumor Necrosis Factors and Anti-Integrins in the Treatment of Crohn's Disease - p. 589 18. Ustekinumab and Anti-Interleukin-23 Agents in Crohn's Disease - p. 603 19. Janus Kinase Antagonists and Other Novel Small Molecules for the Treatment of Crohn's Disease - p. 627 20. Update on Therapeutic Drug Monitoring in Crohn's Disease - p. 645 21. The Evolution of Treatment Paradigms in Crohn's Disease: Beyond Better Drugs - p. 661
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