Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development.
1. Genetics and Neurobiology of Down Syndrome - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Preface - p. xxiii 7. Chapter 1 Down syndrome - p. 1 8. Chapter 2 Implications of trisomy 21 on congenital features and health aspects - p. 13 9. Chapter 3 Chromosomal etiology of Down syndrome - p. 41 10. Chapter 4 Possible factors contributing to chromosomal nondisjunction and formation of trisomic HSA21 - p. 59 11. Chapter 5 Prevention of Down syndrome - p. 71 12. Chapter 6 Gene-dosage imbalance due to trisomic HSA21 and genotype–phenotype association in Down syndrome - p. 93 13. Chapter 7 Development of specific phenotypes and genetic consequences in Down syndrome - p. 135 14. Chapter 8 Triplicated HSA21 genes and mtDNA on mitochondrial dysfunction - p. 181 15. Chapter 9 Disarrayed mitochondrial function on pathobiology in Down syndrome and targeted therapeutics - p. 219 16. Chapter 10 Gene-dosage imbalance and altered neurogenesis in Down syndrome - p. 245 17. Chapter 11 Imbalance in glutamatergic and GABAergic transmission in Down syndrome and therapeutic targets - p. 275 18. Chapter 12 Alzheimer disease and neuroinflammation in Down syndrome - p. 321 19. Chapter 13 MicroRNAs and epigenetic signatures in Down syndrome - p. 369 20. Chapter 14 In vivo and in vitro models for research on Down syndrome - p. 405 21. Index - p. 465
Genetics and Neurobiology of Down Syndrome provides a thorough review of the genetic etiology and mechanisms of trisomy 21. The author discusses the history of the syndrome, along with the clinical features and health consequences, including physical features, cognitive, and neurologic symptoms. Genetic counseling on pros and cons of prenatal screening and testing and associated ethical issues are explored. This unique book also covers the societal and demographic aspects as well as the future direction of therapeutic development.
1. Genetics and Neurobiology of Down Syndrome - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. Preface - p. xxiii 7. Chapter 1 Down syndrome - p. 1 8. Chapter 2 Implications of trisomy 21 on congenital features and health aspects - p. 13 9. Chapter 3 Chromosomal etiology of Down syndrome - p. 41 10. Chapter 4 Possible factors contributing to chromosomal nondisjunction and formation of trisomic HSA21 - p. 59 11. Chapter 5 Prevention of Down syndrome - p. 71 12. Chapter 6 Gene-dosage imbalance due to trisomic HSA21 and genotype–phenotype association in Down syndrome - p. 93 13. Chapter 7 Development of specific phenotypes and genetic consequences in Down syndrome - p. 135 14. Chapter 8 Triplicated HSA21 genes and mtDNA on mitochondrial dysfunction - p. 181 15. Chapter 9 Disarrayed mitochondrial function on pathobiology in Down syndrome and targeted therapeutics - p. 219 16. Chapter 10 Gene-dosage imbalance and altered neurogenesis in Down syndrome - p. 245 17. Chapter 11 Imbalance in glutamatergic and GABAergic transmission in Down syndrome and therapeutic targets - p. 275 18. Chapter 12 Alzheimer disease and neuroinflammation in Down syndrome - p. 321 19. Chapter 13 MicroRNAs and epigenetic signatures in Down syndrome - p. 369 20. Chapter 14 In vivo and in vitro models for research on Down syndrome - p. 405 21. Index - p. 465
