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This issue of Endocrinology Clinics brings the reader up to date on the important advances in research surrounding the neuroendocrine control of metabolism. Guest edited by Christoph Buettner, the topics covered include leptin signaling, hypothalamic inflammation, hypoglycemia awareness, perinatal programming of metabolic disease, substrates, and more.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 5 6. Foreword - p. 6 7. Preface - p. 8 8. Brain Control of Insulin and Glucagon Secretion - p. 9 9. Defective Counterregulation and Hypoglycemia Unawareness in Diabetes - p. 18 10. Novel Approaches to Studying the Role of Innervation in the Biology of Pancreatic Islets - p. 31 11. Hypothalamic Astrocytes in Obesity - p. 40 12. Regulation of Peripheral Metabolism by Substrate Partitioning in the Brain - p. 46 13. Central Leucine Sensing in the Control of Energy Homeostasis - p. 56 14. Novel Aspects of Brown Adipose Tissue Biology - p. 60 15. Brain Insulin and Leptin Signaling in Metabolic Control - p. 71 16. Integrating Metabolism and Longevity Through Insulin and IGF1 Signaling - p. 82 17. Perinatal Programming of Metabolic Diseases - p. 95 18. Index - p. 104

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This issue of Endocrinology Clinics brings the reader up to date on the important advances in research surrounding the neuroendocrine control of metabolism. Guest edited by Christoph Buettner, the topics covered include leptin signaling, hypothalamic inflammation, hypoglycemia awareness, perinatal programming of metabolic disease, substrates, and more.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 5 6. Foreword - p. 6 7. Preface - p. 8 8. Brain Control of Insulin and Glucagon Secretion - p. 9 9. Defective Counterregulation and Hypoglycemia Unawareness in Diabetes - p. 18 10. Novel Approaches to Studying the Role of Innervation in the Biology of Pancreatic Islets - p. 31 11. Hypothalamic Astrocytes in Obesity - p. 40 12. Regulation of Peripheral Metabolism by Substrate Partitioning in the Brain - p. 46 13. Central Leucine Sensing in the Control of Energy Homeostasis - p. 56 14. Novel Aspects of Brown Adipose Tissue Biology - p. 60 15. Brain Insulin and Leptin Signaling in Metabolic Control - p. 71 16. Integrating Metabolism and Longevity Through Insulin and IGF1 Signaling - p. 82 17. Perinatal Programming of Metabolic Diseases - p. 95 18. Index - p. 104

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