Prognostic and Therapeutic Applications of RKIP in Cancer provides updated reviews on the chemistry, signaling, pre-clinical and clinical activities, and role of RKIP expression levels for diagnostics, prognosis and potential interventions. The development of novel compounds and conjugates that selectively induce RKIP expression in cancer open a novel era of new therapeutics and their potential in the treatment of highly resistant cancers and metastases. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Highlights of the 2nd international symposium on prognostic and therapeutic implication of RKIP in cancer - p. page_v 6. About the Editors - p. page_xix 7. Preface - p. page_xxi 8. Contributors - p. page_xxxiii 9. Part I: RKIP: General properties in human malignancies - p. page_xxxiv 10. Chapter 1: Insight on the role of RKIP in cancer through key protein partners and cellular protrusions - p. page_xxxiv 11. Chapter 2: Function of BACH1 as a key target of RKIP in breast cancer - p. page_35 12. Chapter 3: Pleiotropic activities of RKIP in cancer: Role in survival, EMT, chemo-immuno-resistance, and autophagy - p. page_45 13. Chapter 4: Role of RKIP in the tumor response to photooxidative damage - p. page_75 14. Chapter 5: A review of RKIP promotion of tumor progression, metastasis and poor outcome in multiple solid tumor types - p. page_93 15. Chapter 6: Tumor hypoxic stress, cellular plasticity and RKIP - p. page_113 16. Chapter 7: RKIP in uterine tissues - p. page_120 17. Chapter 8: The role of RAF kinase inhibitor protein in hematologic malignancies - p. page_125 18. Part II: RKIP regulation and crosstalks - p. page_136 19. Chapter 9: Regulation of RKIP expression in breast cancer cells by miRNAs - p. page_136 20. Chapter 10: RKIP & GSK3β: The interaction of two intracellular signaling network regulators and their role in cancer - p. page_146 21. Chapter 11: Identification of regulatory crosstalks between RKIP and BRCA1 tumor suppressors in healthy tissues and cancer (breast and ovarian): Therapeutic implications - p. page_173 22. Chapter 12: RKIP a master of regulatory pathways: Perspectives - p. page_209 23. Chapter 13: Local and systemic endothelial cell response to cancer: RKIP-mimetic therapy and endothelial safety - p. page_225 24. Chapter 14: Stochastic modeling for investigation of the regulation of transcription of the RKIP gene - p. page_255 25. Chapter 15: Anti-cancer effect of RKIP via modulating autophagy during metastasis - p. page_276 26. Part III: RKIP and inflammation - p. page_293 27. Chapter 16: The role of Raf kinase inhibitory protein in inflammation - p. page_293 28. Chapter 17: Role of RKIP in inflammatory responses - p. page_322 29. Part IV: RKIP: Prognostic and therapeutic implications - p. page_333 30. Chapter 18: RKIP in human diseases and its potential as a prognostic indicator and therapeutic target - p. page_333 31. Chapter 19: Therapeutic targeting of SNAIL, RKIP, and YY1 in tumor metastasis and drug resistance - p. page_356 32. Chapter 20: Implications of RKIP protein in cancer prognosis and therapy response: A literature update - p. page_387 33. Chapter 21: Theranostic role of RKIP in cancer - p. page_414 34. Chapter 22: Downregulation of the Raf kinase inhibitory protein (RKIP) in clear cell renal cell carcinoma associates with poor prognosis - p. page_434 35. Index - p. page_459
Prognostic and Therapeutic Applications of RKIP in Cancer provides updated reviews on the chemistry, signaling, pre-clinical and clinical activities, and role of RKIP expression levels for diagnostics, prognosis and potential interventions. The development of novel compounds and conjugates that selectively induce RKIP expression in cancer open a novel era of new therapeutics and their potential in the treatment of highly resistant cancers and metastases. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Highlights of the 2nd international symposium on prognostic and therapeutic implication of RKIP in cancer - p. page_v 6. About the Editors - p. page_xix 7. Preface - p. page_xxi 8. Contributors - p. page_xxxiii 9. Part I: RKIP: General properties in human malignancies - p. page_xxxiv 10. Chapter 1: Insight on the role of RKIP in cancer through key protein partners and cellular protrusions - p. page_xxxiv 11. Chapter 2: Function of BACH1 as a key target of RKIP in breast cancer - p. page_35 12. Chapter 3: Pleiotropic activities of RKIP in cancer: Role in survival, EMT, chemo-immuno-resistance, and autophagy - p. page_45 13. Chapter 4: Role of RKIP in the tumor response to photooxidative damage - p. page_75 14. Chapter 5: A review of RKIP promotion of tumor progression, metastasis and poor outcome in multiple solid tumor types - p. page_93 15. Chapter 6: Tumor hypoxic stress, cellular plasticity and RKIP - p. page_113 16. Chapter 7: RKIP in uterine tissues - p. page_120 17. Chapter 8: The role of RAF kinase inhibitor protein in hematologic malignancies - p. page_125 18. Part II: RKIP regulation and crosstalks - p. page_136 19. Chapter 9: Regulation of RKIP expression in breast cancer cells by miRNAs - p. page_136 20. Chapter 10: RKIP & GSK3β: The interaction of two intracellular signaling network regulators and their role in cancer - p. page_146 21. Chapter 11: Identification of regulatory crosstalks between RKIP and BRCA1 tumor suppressors in healthy tissues and cancer (breast and ovarian): Therapeutic implications - p. page_173 22. Chapter 12: RKIP a master of regulatory pathways: Perspectives - p. page_209 23. Chapter 13: Local and systemic endothelial cell response to cancer: RKIP-mimetic therapy and endothelial safety - p. page_225 24. Chapter 14: Stochastic modeling for investigation of the regulation of transcription of the RKIP gene - p. page_255 25. Chapter 15: Anti-cancer effect of RKIP via modulating autophagy during metastasis - p. page_276 26. Part III: RKIP and inflammation - p. page_293 27. Chapter 16: The role of Raf kinase inhibitory protein in inflammation - p. page_293 28. Chapter 17: Role of RKIP in inflammatory responses - p. page_322 29. Part IV: RKIP: Prognostic and therapeutic implications - p. page_333 30. Chapter 18: RKIP in human diseases and its potential as a prognostic indicator and therapeutic target - p. page_333 31. Chapter 19: Therapeutic targeting of SNAIL, RKIP, and YY1 in tumor metastasis and drug resistance - p. page_356 32. Chapter 20: Implications of RKIP protein in cancer prognosis and therapy response: A literature update - p. page_387 33. Chapter 21: Theranostic role of RKIP in cancer - p. page_414 34. Chapter 22: Downregulation of the Raf kinase inhibitory protein (RKIP) in clear cell renal cell carcinoma associates with poor prognosis - p. page_434 35. Index - p. page_459
