Protein-Protein Interactions in Human Disease, Volume 111, Part B, promotes further research and development in the protein interaction network in order to identify critical proteins involved in the etiology of human diseases and locate new protein targets for drug development. Thus, this volume is of considerable interest to protein chemists, pharmacologists, cell biologists, immunologists, structural biologists, computational biochemists and other researchers working in the field. In addition, these articles would be of great benefit to medical, biology and pharmacology students who specialize in this field.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xi 7. Chapter One: Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design - p. xi 8. Chapter Two: Targeting Intramembrane Protein–Protein Interactions: Novel Therapeutic Strategy of Millions Years Old - p. 59 9. Chapter Three: Targeting the Architecture of Deregulated Protein Complexes in Cancer - p. 99 10. Chapter Four: Multifaceted Nucleolin Protein and Its Molecular Partners in Oncogenesis - p. 132 11. Chapter Five: Subcellular Targeting of Nitric Oxide Synthases Mediated by Their N-Terminal Motifs - p. 164 12. Chapter Six: Development of Protein–Protein Interaction Inhibitors for the Treatment of Infectious Diseases - p. 195 13. Chapter Seven: Defining Pharmacological Targets by Analysis of Virus–Host Protein Interactions - p. 222 14. Chapter Eight: Investigating the Influence of Hotspot Mutations in Protein–Protein Interaction of IDH1 Homodimer Protein: A Computational Approach - p. 242 15. Chapter Nine: Human Interactomics: Comparative Analysis of Different Protein Interaction Resources and Construction of a Cancer Protein–Drug Bipartite Network - p. 261
Protein-Protein Interactions in Human Disease, Volume 111, Part B, promotes further research and development in the protein interaction network in order to identify critical proteins involved in the etiology of human diseases and locate new protein targets for drug development. Thus, this volume is of considerable interest to protein chemists, pharmacologists, cell biologists, immunologists, structural biologists, computational biochemists and other researchers working in the field. In addition, these articles would be of great benefit to medical, biology and pharmacology students who specialize in this field.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xi 7. Chapter One: Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design - p. xi 8. Chapter Two: Targeting Intramembrane Protein–Protein Interactions: Novel Therapeutic Strategy of Millions Years Old - p. 59 9. Chapter Three: Targeting the Architecture of Deregulated Protein Complexes in Cancer - p. 99 10. Chapter Four: Multifaceted Nucleolin Protein and Its Molecular Partners in Oncogenesis - p. 132 11. Chapter Five: Subcellular Targeting of Nitric Oxide Synthases Mediated by Their N-Terminal Motifs - p. 164 12. Chapter Six: Development of Protein–Protein Interaction Inhibitors for the Treatment of Infectious Diseases - p. 195 13. Chapter Seven: Defining Pharmacological Targets by Analysis of Virus–Host Protein Interactions - p. 222 14. Chapter Eight: Investigating the Influence of Hotspot Mutations in Protein–Protein Interaction of IDH1 Homodimer Protein: A Computational Approach - p. 242 15. Chapter Nine: Human Interactomics: Comparative Analysis of Different Protein Interaction Resources and Construction of a Cancer Protein–Drug Bipartite Network - p. 261
