The Value of BCG and TNF in Autoimmune Diseases, Second Edition provides an overview on the current research related to TNF induction and the use of the BCG vaccine as a potential treatment approach to diverse forms of autoimmunity, allergies, infections and neurologic diseases. Since the initial conference (2013) and first edition of this book (2014), the field of BCG research has grown considerably. This new edition contains updates on MS and diabetes, and features at least eight additional chapters on new prevention and treatment trials in autoimmunity and allergy, along with a new understanding of the genetics of BCGs.
1. Introduction - p. xv 2. Chapter 1: BCG: Its Impact on Tuberculosis and Relevance to Autoimmune Disease - p. xvi 3. Chapter 2: The Potential of TNF Induction From BCG for the Treatment of Type 1 Diabetes - p. 10 4. Chapter 3: Bacille Calmette-Guérin (BCG) Vaccine in Neuroinflammation - p. 24 5. Chapter 4: Host Epigenetic Modifications in Mycobacterium tuberculosis Infection: A Boon or Bane - p. 38 6. Chapter 5: Mycobacterium Bovis Bacille Calmette-Guerin Vaccination: Can Biomarkers Predict Efficacy? - p. 55 7. Chapter 6: The Heterologous Effects of Bacillus Calmette-Guérin (BCG) Vaccine and Trained Innate Immunity - p. 70 8. Chapter 7: Nonspecific Effects of Neonatal Bacille Calmette-Guérin (BCG) Vaccination—From West African Observations to a Danish Randomized Clinical Trial - p. 90 9. Chapter 8: Epigenetic Rewiring of Monocytes in BCG Vaccination - p. 108 10. Chapter 9: Mycobacteria, Immunoregulation, and Autoimmunity - p. 120 11. Chapter 10: mTORC1 Links Cellular Metabolism and Immune Functions in Mycobacterium tuberculosis Infection and BCG Vaccination - p. 154 12. Chapter 11: The Role of Maternal Priming and Boosting for the Nonspecific Effects of BCG Vaccine - p. 170 13. Index - p. 179
The Value of BCG and TNF in Autoimmune Diseases, Second Edition provides an overview on the current research related to TNF induction and the use of the BCG vaccine as a potential treatment approach to diverse forms of autoimmunity, allergies, infections and neurologic diseases. Since the initial conference (2013) and first edition of this book (2014), the field of BCG research has grown considerably. This new edition contains updates on MS and diabetes, and features at least eight additional chapters on new prevention and treatment trials in autoimmunity and allergy, along with a new understanding of the genetics of BCGs.
1. Introduction - p. xv 2. Chapter 1: BCG: Its Impact on Tuberculosis and Relevance to Autoimmune Disease - p. xvi 3. Chapter 2: The Potential of TNF Induction From BCG for the Treatment of Type 1 Diabetes - p. 10 4. Chapter 3: Bacille Calmette-Guérin (BCG) Vaccine in Neuroinflammation - p. 24 5. Chapter 4: Host Epigenetic Modifications in Mycobacterium tuberculosis Infection: A Boon or Bane - p. 38 6. Chapter 5: Mycobacterium Bovis Bacille Calmette-Guerin Vaccination: Can Biomarkers Predict Efficacy? - p. 55 7. Chapter 6: The Heterologous Effects of Bacillus Calmette-Guérin (BCG) Vaccine and Trained Innate Immunity - p. 70 8. Chapter 7: Nonspecific Effects of Neonatal Bacille Calmette-Guérin (BCG) Vaccination—From West African Observations to a Danish Randomized Clinical Trial - p. 90 9. Chapter 8: Epigenetic Rewiring of Monocytes in BCG Vaccination - p. 108 10. Chapter 9: Mycobacteria, Immunoregulation, and Autoimmunity - p. 120 11. Chapter 10: mTORC1 Links Cellular Metabolism and Immune Functions in Mycobacterium tuberculosis Infection and BCG Vaccination - p. 154 12. Chapter 11: The Role of Maternal Priming and Boosting for the Nonspecific Effects of BCG Vaccine - p. 170 13. Index - p. 179
