Year Book of Pathology and Laboratory Medicine 2014

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. 1. Outcomes Analysis - p. 8 5. Consensus Statement on Effective Communication of Urgent Diagnoses and Significant, Unexpected Diagnoses in Surgical Pathology and Cytopathology From the College of American Pathologists and Association of Directors of Anatomic and Surgical Pathology - p. 9 6. The Ideal Laboratory Information System - p. 10 7. Frozen Section Diagnosis: Is There Discordance Between What Pathologists Say and What Surgeons Hear? - p. 11 8. Clinician compliance with laboratory regulations requiring submission of relevant clinical data: A one year retrospective analysis - p. 12 9. Equivocal or Ambiguous Terminologies in Pathology: Focus of Continuous Quality Improvement? - p. 13 10. Accounting for the Professional Work of Pathologists Performing Autopsies - p. 14 11. Template-based synoptic reports improve the quality of pathology reports of prostatectomy specimens - p. 15 12. Utility of whole slide imaging and virtual microscopy in prostate pathology - p. 16 13. Approach to Intraoperative Consultation for Donor Liver Biopsies - p. 17 14. Outside Case Review of Surgical Pathology for Referred Patients: The Impact on Patient Care - p. 18 15. Cervical Histopathology Variability Among Laboratories: A Population-Based Statewide Investigation - p. 19 16. 2. Breast - p. 20 17. Assessing the Potential Cost-Effectiveness of Retesting IHC0, IHC1+, or FISH-Negative Early Stage Breast Cancer Patients for HER2 Status - p. 21 18. Are Physician Recommendations for BRCA1/2 Testing in Patients With Breast Cancer Appropriate? A Population-Based Study - p. 22 19. Borderline Atypical Ductal Hyperplasia/Low-grade Ductal Carcinoma In Situ on Breast Needle Core Biopsy Should Be Managed Conservatively - p. 23 20. Molecular alterations in metaplastic breast carcinoma - p. 24 21. Primary Squamous Cell Carcinoma of the Breast: Predictors of Locoregional Recurrence and Overall Survival - p. 25 22. Ductal carcinoma in situ associated with triple negative invasive breast cancer: evidence for a precursor–product relationship - p. 26 23. Pitfalls in outcome prediction of breast cancer - p. 27 24. Clinicopathological significance of CADM4 expression in invasive ductal carcinoma of the breast - p. 28 25. Use of immunohistochemistry in the diagnosis of problematic breast lesions - p. 29 26. 3. Gastrointestinal System - p. 30 27. Filiform polyps and filiform polyp–like lesions are common in defunctioned or diverted colorectum resection specimens - p. 31 28. Characterization of Perineural Invasion as a Component of Colorectal Cancer Staging - p. 32 29. Histologic Features and Cytologic Techniques That Aid Pathologic Stage Assessment of Colonic Adenocarcinoma - p. 33 30. Microcystic/Reticular Schwannoma of the Proximal Sigmoid Colon: Case Report With Review of Literature - p. 34 31. Reporting trends of right-sided hyperplastic and sessile serrated polyps in a large teaching hospital over a 4-year period (2009–2012) - p. 35 32. Clinicopathologic Features of Synchronous Colorectal Carcinoma: A Distinct Subset Arising From Multiple Sessile Serrated Adenomas and Associated With High Levels of Microsatellite Instability and Favorable Prognosis - p. 36 33. Impact of Age on the Quality of Lymphadenectomy for Colorectal Cancer - p. 37 34. 4. Hepatobiliary System and Pancreas - p. 38 35. Histologic Findings Predictive of a Diagnosis of De novo Autoimmune Hepatitis After Liver Transplantation in Adults - p. 39 36. The Hepatitis Aggressiveness Score (HAS): A Novel Classification System for Post–Liver Transplantation Recurrent Hepatitis C - p. 40 37. Acute Hepatitis With Periportal Confluent Necrosis Associated With Human Herpesvirus 6 Infection in Liver Transplant Patients - p. 41 38. Pathology report assessment of incidental gallbladder carcinoma diagnosed from cholecystectomy specimens: Results of a French multicentre survey - p. 42 39. Hepatic Histological Findings in Suspected Drug-Induced Liver Injury: Systematic Evaluation and Clinical Associations - p. 43 40. Clinicopathologic Analysis of Combined Hepatocellular-Cholangiocarcinoma According to the Latest WHO Classification - p. 44 41. Immunohistochemical characteristics of hepatocellular carcinoma in non-cirrhotic livers - p. 45 42. Histopathologic Distinction Between Fibrosing Cholestatic Hepatitis C and Biliary Obstruction - p. 46 43. Hepatic steatosis estimated microscopically versus digital image analysis - p. 47 44. Diagnostic utility and limitations of glutamine synthetase and serum amyloid-associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and inflammatory hepatocellular adenoma - p. 48 45. “Plasma Cell Hepatitis” in Liver Allografts: Identification and Characterization of an IgG4-Rich Cohort - p. 49 46. Revisiting the Topic of Histochemically Detectable Copper in Various Liver Diseases with Special Focus on Venous Outflow Impairment - p. 50 47. 5. Lung and Mediastinum - p. 51 48. Smoking-related interstitial fibrosis (SRIF): pathologic findings and distinction from other chronic fibrosing lung diseases - p. 52 49. Fibrosing interstitial pneumonia predicts survival in patients with rheumatoid arthritis-associated interstitial lung disease (RA-ILD) - p. 53 50. End-stage Sarcoid Lung Disease Is Distinct From Usual Interstitial Pneumonia - p. 54 51. Bronchoscopic Cryobiopsy for the Diagnosis of Diffuse Parenchymal Lung Disease - p. 55 52. Nodular Pulmonary Amyloidosis Is Characterized by Localized Immunoglobulin Deposition and Is Frequently Associated With an Indolent B-cell Lymphoproliferative Disorder - p. 56 53. Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology - p. 57 54. Mesothelioma with signet-ring cell features: report of 23 cases - p. 58 55. Intrapulmonary Solitary Fibrous Tumors: Clinicopathologic and Immunohistochemical Study of 24 Cases - p. 59 56. Localized Pleuropulmonary Crystal-storing Histiocytosis: 5 Cases of a Rare Histiocytic Disorder With Variable Clinicoradiologic Features - p. 60 57. Pathology of pulmonary antibody-mediated rejection: 2012 update from the Pathology Council of the ISHLT - p. 61 58. Immunohistochemical Study of 36 Cases of Pulmonary Sarcomatoid Carcinoma—Sensitivity of TTF-1 is Superior to Napsin - p. 63 59. Diffuse Intrapulmonary Malignant Mesothelioma Masquerading as Interstitial Lung Disease: A Distinctive Variant of Mesothelioma - p. 64 60. 6. Soft Tissue and Bone - p. 65 61. Impact of Molecular Analysis on the Final Sarcoma Diagnosis: A Study on 763 Cases Collected During a European Epidemiological Study - p. 66 62. Fibrosarcoma-like Lipomatous Neoplasm: A Reappraisal of So-called Spindle Cell Liposarcoma Defining a Unique Lipomatous Tumor Unrelated to Other Liposarcomas - p. 67 63. 7. Female Genital Tract - p. 68 64. Interobserver Agreement for Assessing Invasion in Stage 1A Vulvar Squamous Cell Carcinoma - p. 69 65. A comparison of cervical histopathology variability using whole slide digitized images versus glass slides: experience with a statewide registry - p. 70 66. Cervical Squamocolumnar Junction–specific Markers Define Distinct, Clinically Relevant Subsets of Low-grade Squamous Intraepithelial Lesions - p. 71 67. Implementation of tumor testing for lynch syndrome in endometrial cancers at a large academic medical center - p. 72 68. Histologic and Immunohistochemical Analyses of Endometrial Carcinomas: Experiences From Endometrial Biopsies in 358 Consultation Cases - p. 73 69. Toward standard HER2 testing of endometrial serous carcinoma: 4-year experience at a large academic center and recommendations for clinical practice - p. 74 70. The Pattern of Myometrial Invasion as a Predictor of Lymph Node Metastasis or Extrauterine Disease in Low-grade Endometrial Carcinoma - p. 75 71. Prediction of lymph node and distant metastasis in patients with endometrial carcinoma: A new model based on demographics, biochemical factors, and tumor histology - p. 76 72. Comparison of Current Staging Systems and a Novel Staging System for Uterine Leiomyosarcoma - p. 77 73. Endometrial Stromal Sarcomas With Sex Cord Differentiation Are Associated With PHF1 Rearrangement - p. 78 74. An Immunohistochemical Panel to Distinguish Ovarian From Uterine Serous Papillary Carcinomas - p. 79 75. Hormone-receptor expression and ovarian cancer survival: an Ovarian Tumor Tissue Analysis consortium study - p. 80 76. Pathologic Examination of Fetal and Placental Tissue Obtained by Dilation and Evacuation - p. 81 77. 8. Kidney - p. 82 78. Epithelioid angiomyolipoma of the kidney: pathological features and clinical outcome in a series of consecutively resected tumors - p. 83 79. Synovial Sarcoma of the Kidney: A Clinicopathologic, Immunohistochemical, and Molecular Genetic Study of 16 Cases - p. 84 80. Banff Initiative for Quality Assurance in Transplantation (BIFQUIT): Reproducibility of C4d Immunohistochemistry in Kidney Allografts - p. 85 81. What do we know about adenovirus in renal transplantation? - p. 86 82. Localized Cystic Disease of the Kidney: Distinction from Cystic Neoplasms and Hereditary Polycystic Diseases - p. 87 83. Validation of the new classification of pauci-immune glomerulonephritis in a United States cohort and its correlation with renal outcome - p. 88 84. Glomerular tip adhesions predict the progression of IgA nephropathy - p. 89 85. C3 glomerulopathy: consensus report - p. 90 86. The reproducibility and predictive value on outcome of renal biopsies from expanded criteria donors - p. 91 87. Long-term Kidney Disease Outcomes in Fibrillary Glomerulonephritis: A Case Series of 27 Patients - p. 92 88. IgG subclass staining in renal biopsies with membranous glomerulonephritis indicates subclass switch during disease progression - p. 93 89. Nonneoplastic Renal Cortical Scarring at Tumor Nephrectomy Predicts Decline in Kidney Function - p. 94 90. 9. Head and Neck - p. 95 91. Human Papillomavirus–related Carcinoma With Adenoid Cystic–like Features: A Peculiar Variant of Head and Neck Cancer Restricted to the Sinonasal Tract - p. 96 92. Human Papillomavirus-related Carcinomas of the Sinonasal Tract - p. 97 93. Molecular profiling of sinonasal undifferentiated carcinoma - p. 98 94. Sinonasal mucosal melanomas: The prognostic value of tumor classifications - p. 99 95. Epithelial salivary gland tumors in children: A twenty-five-year experience of 122 patients - p. 100 96. Cytomegalovirus-induced salivary gland pathology: AREG, FGF8, TNF-α, and IL-6 signal dysregulation and neoplasia - p. 101 97. Lipomatous Salivary Gland Tumors: A Series of 31 Cases Spanning Their Morphologic Spectrum With Emphasis on Sialolipoma and Oncocytic Lipoadenoma - p. 102 98. Human papillomaviruses are not involved in the etiopathogenesis of salivary gland tumors - p. 103 99. Primary Inner Ear Schwannomas: A Case Series and Systematic Review of the Literature - p. 104 100. Follicular epithelial dysplasia of the thyroid: morphological and immunohistochemical characterization of a putative preneoplastic lesion to papillary thyroid carcinoma in chronic lymphocytic thyroiditis - p. 105 101. Aggressive variants of follicular cell derived thyroid carcinoma; the so called ‘Real Thyroid Carcinomas’ - p. 106 102. Biomarkers of Parathyroid Carcinoma - p. 107 103. 10. Cytopathology - p. 108 104. Cytology of Spontaneous Nipple Discharge—Is It Worth It? Performance of Nipple Discharge Preparations in the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytopathology - p. 109 105. Assessment of Malignancy for Atypia of Undetermined Significance in Thyroid Fine-Needle Aspiration Biopsy Evaluated by Whole-Slide Image Analysis - p. 110 106. The Diagnostic Reliability of Urinary Cytology: A Retrospective Study - p. 111 107. A simplified economic approach to thyroid FNA cytology and surgical intervention in thyroid nodules - p. 112 108. Interobserver agreement in determining non-small cell lung cancer subtype in specimens acquired by EBUS-TBNA - p. 113 109. Women's preferences regarding options for management of atypical, borderline or low-grade cervical cytological abnormalities: a review of the evidence - p. 114 110. Factors contributing to false-negative and potential false-negative cytology reports in SurePath™ liquid-based cervical cytology - p. 115 111. Large performance variation does not affect outcome in the Finnish cervical cancer screening programme - p. 116 112. Assessment of Manual Workload Limits in Gynecologic Cytology: Reconciling Data From 3 Major Prospective Trials of Automated Screening Devices - p. 117 113. 11. Hematolymphoid - p. 118 114. Anaplastic Large Cell Lymphoma: A Potential Pitfall in the Differential Diagnosis of Melanoma - p. 119 115. Comparison Between 1-Needle Technique Versus 2-Needle Technique for Bone Marrow Aspiration and Biopsy Procedures - p. 120 116. 12. Techniques/Molecular - p. 121 117. Deep ion sequencing of amplicon adapter ligated libraries: a novel tool in molecular diagnostics of formalin fixed and paraffin embedded tissues - p. 122 118. Molecular genetic testing for lung adenocarcinomas: a practical approach to clinically relevant mutations and translocations - p. 123 119. Fluorescence confocal microscopy for pathologists - p. 124 120. Are we counting mitoses correctly? - p. 125 121. False positivity in HER2 testing of breast cancer: novel paths for approaching an old dilemma - p. 126 122. Gene of the month: KRAS - p. 127 123. 13. Laboratory Management and Outcomes - p. 128 124. Transformation of Pathologists: Responding in a Volatile, Uncertain, Complex, and Ambiguous Environment - p. 129 125. Federal Laboratory–Business Commercialization Partnerships - p. 130 126. Laboratory Test Utilization Program: Structure and Impact in a Large Academic Medical Center - p. 131 127. Should we customise critical value procedure according to patient origin and laboratory turnaround time? - p. 132 128. Teaching Laboratory Medicine to Medical Students: Implementation and Evaluation - p. 133 129. Utilization of Stat Test Priority in the Clinical Laboratory: A College of American Pathologists Q-Probes Study of 52 Institutions - p. 134 130. Rate of Occult Specimen Provenance Complications in Routine Clinical Practice - p. 135 131. Determination of Turnaround Time in the Clinical Laboratory: “Accessioning-to-Result” Time Does Not Always Accurately Reflect Laboratory Performance - p. 136 132. Managing demand for laboratory tests: a laboratory toolkit - p. 137 133. Evaluating the Connections Between Primary Care Practice and Clinical Laboratory Testing: A Review of the Literature and Call for Laboratory Involvement in the Solutions - p. 138 134. 14. Clinical Chemistry - p. 139 135. Design of Tumor Biomarker–Monitoring Trials: A Proposal by the European Group on Tumor Markers - p. 140 136. Unresolved Discrepancies between Cannabinoid Test Results for Infant Urine - p. 141 137. Quantifying the Accuracy of a Diagnostic Test or Marker - p. 142 138. Alternative Calibration Strategies for the Clinical Laboratory: Application to Nortriptyline Therapeutic Drug Monitoring - p. 143 139. Evaluation of the health effects of occupational exposure of analytic laboratory workers processing illicit drug investigation files - p. 144 140. Short- and Long-term Individual Variation in Cardiac Troponin in Patients with Stable Coronary Artery Disease - p. 145 141. Unleashing the Power of Proteomics to Develop Blood-Based Cancer Markers - p. 146 142. Serum human epididymis protein 4 vs carbohydrate antigen 125 for ovarian cancer diagnosis: a systematic review - p. 147 143. Toxicological analysis of blood and urine samples from female victims of alleged sexual assault - p. 148 144. Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study - p. 149 145. Albuminuria Prevalence in First Morning Void Compared with Previous Random Urine from Adults in the National Health and Nutrition Examination Survey, 2009–2010 - p. 150 146. 15. Clinical Microbiology - p. 151 147. CHROMagar Yersinia, a New Chromogenic Agar for Screening of Potentially Pathogenic Yersinia enterocolitica Isolates in Stools - p. 152 148. Assessment of Real-Time PCR Assay for Detection of Rickettsia spp. and Rickettsia rickettsii in Banked Clinical Samples - p. 153 149. Detection of Hepatitis C Virus Transmission by Use of DNA Mass Spectrometry - p. 154 150. Using the rate of bacterial clearance determined by real-time polymerase chain reaction as a timely surrogate marker to evaluate the appropriateness of antibiotic usage in critical patients with Acinetobacter baumannii bacteremia - p. 155 151. Cytomegalovirus DNA in Semen and Blood Is Associated With Higher Levels of Proviral HIV DNA - p. 156 152. Is It Time to Replace the Tuberculin Skin Test With a Blood Test? - p. 157 153. Respiratory Viral Coinfections Identified by a 10-Plex Real-Time Reverse-Transcription Polymerase Chain Reaction Assay in Patients Hospitalized With Severe Acute Respiratory Illness—South Africa, 2009–2010 - p. 158 154. A Cohort Effect of the Sexual Revolution May Be Masking an Increase in Human Papillomavirus Detection at Menopause in the United States - p. 159 155. Diagnostic Accuracy of Histopathologic and Cytopathologic Examination of Aspergillus Species - p. 160 156. Comparison of 2 Blood Culture Media Shows Significant Differences in Bacterial Recovery for Patients on Antimicrobial Therapy - p. 161 157. Real-time polymerase chain reaction testing for Clostridium difficile reduces isolation time and improves patient management in a small community hospital - p. 162 158. 16. Hematology and Immunology - p. 163 159. The Differential Diagnosis and Bone Marrow Evaluation of New-Onset Pancytopenia - p. 164 160. Comparison of Automated Differential Blood Cell Counts From Abbott Sapphire, Siemens Advia 120, Beckman Coulter DxH 800, and Sysmex XE-2100 in Normal and Pathologic Samples - p. 165 161. Comparison of a powered bone marrow biopsy device with a manual system: results of a prospective randomised controlled trial - p. 166 162. Design and Feasibility of a Novel, Rapid, and Simple Fluorescence 26-Plex RT-PCR Assay for Simultaneous Detection of 24 Fusion Transcripts in Adult Acute Myeloid Leukemia - p. 167 163. IL-1 Family Members IL-18 and IL-33 Upregulate the Inflammatory Potential of Differentiated Human Th1 and Th2 Cultures - p. 168 164. Chronic Activation of the Kinase IKKβ Impairs T Cell Function and Survival - p. 169 165. Pro-Apoptotic Protein Noxa Regulates Memory T Cell Population Size and Protects against Lethal Immunopathology - p. 170 166. Fine-Tuning of Regulatory T Cell Function: The Role of Calcium Signals and Naive Regulatory T Cells for Regulatory T Cell Deficiency in Multiple Sclerosis - p. 171 167. Complement in Immune and Inflammatory Disorders: Therapeutic Interventions - p. 172 168. Complement in Immune and Inflammatory Disorders: Pathophysiological Mechanisms - p. 173 169. Estimation of cell density to aid in assessment of percentage cells of a particular lineage or of cells expressing a specific antigen in bone marrow trephine biopsies - p. 174 170. 17. Transfusion Medicine and Coagulation - p. 175 171. Analysis of prolonged storage on coagulation Factor (F)V, FVII, and FVIII in thawed plasma: is it time to extend the expiration date beyond 5 days? - p. 176 172. Human T-lymphotropic virus laboratory testing of maternal blood at time of cord blood donations and clinical implications - p. 177 173. Laboratory evaluation of rapid test kits to detect hepatitis C antibody for use in predonation screening in emergency settings - p. 178 174. The role of failure modes and effects analysis in showing the benefits of automation in the blood bank - p. 179 175. Establishment of a medium-throughput approach for the genotyping of RHD variants and report of nine novel rare alleles - p. 180 176. Evaluation of automated immunoassays in the diagnosis of heparin induced thrombocytopenia - p. 181 177. Effect of inositol hexaphosphate–loaded red blood cells (RBCs) on the rheology of sickle RBCs - p. 182 178. Assessment of the impact of rivaroxaban on coagulation assays: Laboratory recommendations for the monitoring of rivaroxaban and review of the literature - p. 183 179. Does Rh immune globulin suppress HLA sensitization in pregnancy? - p. 184 180. Evaluation of single-nucleotide polymorphisms as internal controls in prenatal diagnosis of fetal blood groups - p. 185 181. Fresh and Citrated Whole-Blood Specimens Can Produce Different Thromboelastography Results in Patients on Extracorporeal Membrane Oxygenation - p. 186 182. Small deletions within the RHD coding sequence: a report of two novel mutational events and a survey of the underlying pathophysiologic mechanisms - p. 187 183. Autologous stem cell transplant recipients tolerate haploidentical related-donor natural killer cell–enriched infusions - p. 188 184. Whole-Blood Thrombin Generation Monitored with a Calibrated Automated Thrombogram-Based Assay - p. 189 185. Routine use of a rapid test to detect bacteria at the time of issue for nonleukoreduced, whole blood–derived platelets - p. 190 186. Routine use of a rapid test to detect bacteria at the time of issue for nonleukoreduced, whole blood–derived platelets - p. 191 187. Evaluation of single-nucleotide polymorphisms as internal controls in prenatal diagnosis of fetal blood groups - p. 192 188. Incomplete pretransfusion testing leads to surgical delays - p. 193 189. The Development of a Novel Molecular Assay Examining the Role of Aminopeptidase P Polymorphisms in Acute Hypotensive Transfusion Reactions - p. 194 190. New direct and indirect methods for the detection of cyclooxygenase 1 acetylation by aspirin; the lack of aspirin resistance among healthy individuals - p. 195 191. 18. Cytogenetics and Molecular Pathology - p. 196 192. Exome and Whole-Genome Sequencing as Clinical Tests: A Transformative Practice in Molecular Diagnostics - p. 197 193. Development of a Genomic DNA Reference Material Panel for Myotonic Dystrophy Type 1 (DM1) Genetic Testing - p. 198 194. Very Low PSA Concentrations and Deletions of the KLK3 Gene - p. 199 195. Karyotype versus Microarray Testing for Genetic Abnormalities after Stillbirth - p. 200 196. Chromosomal Microarray versus Karyotyping for Prenatal Diagnosis - p. 201 197. Comparative Analytical Utility of DNA Derived from Alternative Human Specimens for Molecular Autopsy and Diagnostics - p. 202 198. Inherited Cardiomyopathies: Molecular Genetics and Clinical Genetic Testing in the Postgenomic Era - p. 203 199. Bacterial Genomics in Infectious Disease and the Clinical Pathology Laboratory - p. 204 200. Data Submission and Quality in Microarray-Based MicroRNA Profiling - p. 205 201. Diagnosing fetal alcohol syndrome: new insights from newer genetic technologies - p. 206 202. Importance of the Efficiency of Double-Stranded DNA Formation in cDNA Synthesis for the Imprecision of Microarray Expression Analysis - p. 207