Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine.
This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies.
1. 1. Introduction - p. 171 2. 2. Nanozymes for In Vitro Sensing - p. 172 3. 3. Nanozyme for Sensing in Living Systems - p. 197 4. 4. Conclusions and Perspectives - p. 198 5. Abbreviations - p. 200 6. Chapter 8. Systematic Evolution of Ligands by Exponential Enrichment for Aptamer Selection - p. 211 7. Section II. Specific Applications of Functionalized Nanomaterials in Therapy and Diagnostics - p. 243 8. Chapter 9. Graphene-Based Nanomaterials in Bioimaging - p. 247 9. Chapter 10. Functionalized Transition Metal Dichalcogenide-Based Nanomaterials for Biomedical Applications - p. 289 10. Chapter 11. Intracellular Targeting Using Surface-Modified Gold Nanoparticles - p. 315 11. Chapter 12. Multifunctional Magnetic Nanoparticles for Theranostic Applications - p. 335 12. Chapter 13. Combinatorial Approach in Rationale Design of Polymeric Nanomedicines for Cancer - p. 371 13. Chapter 14. Functional Moieties for Intracellular Traffic of Nanomaterials - p. 399 14. 1. Introduction - p. 400 15. 2. Intracellular Delivery: Barriers and Challenges - p. 401 16. 3. Intracellular Delivery by Nanomaterials - p. 406 17. 4. Nanomaterial-Based Strategies to Target Subcellular Organelles - p. 417 18. 5. Conclusions and Future Perspectives - p. 427 19. Chapter 15. Functionalized Polymeric Nanostructures for Mucosal Drug Delivery - p. 449 20. Chapter 16. Biofunctionalized Mesoporous Silica Nanomaterials for Targeted Drug Delivery - p. 489 21. Chapter 17. Nanoparticle-Mediated RNA Interference for Cancer Therapy - p. 521 22. Chapter 18. Biomolecular Therapeutics for HIV - p. 541 23. Chapter 19. Self-Assembled Peptide and Protein Nanofibers for Biomedical Applications - p. 569 24. Chapter 20. Peptide-Modified Hydrogels for Therapeutic Vascularization - p. 599 25. Section III. Manufacturing, Regulatory Challenges and Clinical Testing of Functionalized Nanomaterial-based Products - p. 620 26. Chapter 21. Manufacturing and Safety Guidelines for Manufactured Functionalized Nanomaterials in Pharmaceutics - p. 623 27. Chapter 22. Regulation of Biomedical Applications of Functionalized Nanomaterials in the European Union - p. 653 28. Chapter 23. Translational Exploration and Clinical Testing of Silica–Gold Nanoparticles in Development of Multifunctional Nanoplatform for Theranostics of Atherosclerosis - p. 681 29. 1. Introduction - p. 682 30. 2. Silica–Gold Nanoparticles for Imaging and Therapy of Atherosclerosis - p. 704 31. 3. Future of Nanomedical Applications for Imaging and Therapy of Atherosclerosis - p. 719 32. 4. Conclusion - p. 724 33. 5. Future Perspectives - p. 725 34. Abbreviations - p. 727 35. Index - p. 743
Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine.
This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies.
1. 1. Introduction - p. 171 2. 2. Nanozymes for In Vitro Sensing - p. 172 3. 3. Nanozyme for Sensing in Living Systems - p. 197 4. 4. Conclusions and Perspectives - p. 198 5. Abbreviations - p. 200 6. Chapter 8. Systematic Evolution of Ligands by Exponential Enrichment for Aptamer Selection - p. 211 7. Section II. Specific Applications of Functionalized Nanomaterials in Therapy and Diagnostics - p. 243 8. Chapter 9. Graphene-Based Nanomaterials in Bioimaging - p. 247 9. Chapter 10. Functionalized Transition Metal Dichalcogenide-Based Nanomaterials for Biomedical Applications - p. 289 10. Chapter 11. Intracellular Targeting Using Surface-Modified Gold Nanoparticles - p. 315 11. Chapter 12. Multifunctional Magnetic Nanoparticles for Theranostic Applications - p. 335 12. Chapter 13. Combinatorial Approach in Rationale Design of Polymeric Nanomedicines for Cancer - p. 371 13. Chapter 14. Functional Moieties for Intracellular Traffic of Nanomaterials - p. 399 14. 1. Introduction - p. 400 15. 2. Intracellular Delivery: Barriers and Challenges - p. 401 16. 3. Intracellular Delivery by Nanomaterials - p. 406 17. 4. Nanomaterial-Based Strategies to Target Subcellular Organelles - p. 417 18. 5. Conclusions and Future Perspectives - p. 427 19. Chapter 15. Functionalized Polymeric Nanostructures for Mucosal Drug Delivery - p. 449 20. Chapter 16. Biofunctionalized Mesoporous Silica Nanomaterials for Targeted Drug Delivery - p. 489 21. Chapter 17. Nanoparticle-Mediated RNA Interference for Cancer Therapy - p. 521 22. Chapter 18. Biomolecular Therapeutics for HIV - p. 541 23. Chapter 19. Self-Assembled Peptide and Protein Nanofibers for Biomedical Applications - p. 569 24. Chapter 20. Peptide-Modified Hydrogels for Therapeutic Vascularization - p. 599 25. Section III. Manufacturing, Regulatory Challenges and Clinical Testing of Functionalized Nanomaterial-based Products - p. 620 26. Chapter 21. Manufacturing and Safety Guidelines for Manufactured Functionalized Nanomaterials in Pharmaceutics - p. 623 27. Chapter 22. Regulation of Biomedical Applications of Functionalized Nanomaterials in the European Union - p. 653 28. Chapter 23. Translational Exploration and Clinical Testing of Silica–Gold Nanoparticles in Development of Multifunctional Nanoplatform for Theranostics of Atherosclerosis - p. 681 29. 1. Introduction - p. 682 30. 2. Silica–Gold Nanoparticles for Imaging and Therapy of Atherosclerosis - p. 704 31. 3. Future of Nanomedical Applications for Imaging and Therapy of Atherosclerosis - p. 719 32. 4. Conclusion - p. 724 33. 5. Future Perspectives - p. 725 34. Abbreviations - p. 727 35. Index - p. 743
