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Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple.

Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine.

This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease.

  • Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology.
  • Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software.
  • Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

1. I: Introduction - p. xxviii 2. Chapter 1: Introduction - p. xxviii 3. II: Human disease pathways - p. 32 4. Chapter 2: Infectious diseases - p. 32 5. Chapter 3: Diseases of the blood - p. 94 6. Chapter 4: Endocrine, nutritional, and metabolic diseases - p. 119 7. Chapter 5: Diseases of the nervous system - p. 218 8. Chapter 6: Diseases of the eye - p. 258 9. Chapter 7: Diseases of the ear - p. 296 10. Chapter 8: Diseases of the circulatory system - p. 325 11. Chapter 9: Diseases of the respiratory system - p. 390 12. Chapter 10: Diseases of the digestive system - p. 442 13. Chapter 11: Diseases of the skin and subcutaneous tissue - p. 491 14. Chapter 12: Diseases of the musculoskeletal system - p. 532 15. Chapter 13: Diseases of the genitourinary system - p. 568 16. III: Pathway analysis perspectives/advantages - p. 625 17. Chapter 14: Applications of disease pathways in biology and medicine - p. 625 18. Glossary and index - p. 669 19. Links - p. 681 20. Index - p. 687

Descripcion
Descripción

Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple.

Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine.

This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease.

  • Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology.
  • Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software.
  • Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.

1. I: Introduction - p. xxviii 2. Chapter 1: Introduction - p. xxviii 3. II: Human disease pathways - p. 32 4. Chapter 2: Infectious diseases - p. 32 5. Chapter 3: Diseases of the blood - p. 94 6. Chapter 4: Endocrine, nutritional, and metabolic diseases - p. 119 7. Chapter 5: Diseases of the nervous system - p. 218 8. Chapter 6: Diseases of the eye - p. 258 9. Chapter 7: Diseases of the ear - p. 296 10. Chapter 8: Diseases of the circulatory system - p. 325 11. Chapter 9: Diseases of the respiratory system - p. 390 12. Chapter 10: Diseases of the digestive system - p. 442 13. Chapter 11: Diseases of the skin and subcutaneous tissue - p. 491 14. Chapter 12: Diseases of the musculoskeletal system - p. 532 15. Chapter 13: Diseases of the genitourinary system - p. 568 16. III: Pathway analysis perspectives/advantages - p. 625 17. Chapter 14: Applications of disease pathways in biology and medicine - p. 625 18. Glossary and index - p. 669 19. Links - p. 681 20. Index - p. 687

Indice
Autores
Muestra
Ficha Técnica