For more than 100 years, Henry's Clinical Diagnosis and Management by Laboratory Methods has been recognized as the premier text in clinical laboratory medicine, widely used by both clinical pathologists and laboratory technicians. Leading experts in each testing discipline clearly explain procedures and how they are used both to formulate clinical diagnoses and to plan patient medical care and long-term management. Employing a multidisciplinary approach, it provides cutting-edge coverage of automation, informatics, molecular diagnostics, proteomics, laboratory management, and quality control, emphasizing new testing methodologies throughout.
1. Introduction - p. 182 2. Volumes And Osmolality Of Body Fluid - p. 182 3. Regulation Of Extracellular Volume - p. 186 4. Measurement Of Renal Function - p. 187 5. Biomarkers Of Acute Kidney Injury (AKI) - p. 192 6. Disorders Of Potassium - p. 193 7. Disorders Of Water, Sodium, And Antidiuretic Hormone (ADH) Metabolism - p. 197 8. Acid-Base Disorders - p. 201 9. Chapter 16. Biochemical Markers Of Bone Metabolism - p. 208 10. Chapter 17. Carbohydrates - p. 225 11. CHAPTER 18. Lipids And Dyslipoproteinemia - p. 244 12. Chapter 19. Cardiac Injury, Atherosclerosis, And Thrombotic Disease - p. 267 13. Chapter 20. Specific Proteins - p. 276 14. Chapter 21. Clinical Enzymology - p. 291 15. General Properties of Enzymes - p. 291 16. Enzyme Kinetics: Determination Of Total Enzyme Concentrations In Serum And Other Body Fluids - p. 295 17. Inhibition of Enzymes - p. 300 18. Catalytic Efficiency: Transition State Theory And Drug Design - p. 302 19. Specific Enzymes - p. 305 20. Chapter 22. Evaluation Of Liver Function - p. 314 21. Chapter 23. Laboratory Diagnosis of Gastrointestinal and Pancreatic Disorders - p. 331 22. Chapter 24. Toxicology and Therapeutic Drug Monitoring - p. 347 23. Basic Techniques for Detecting Drugs in Serum and Urine - p. 347 24. The Drugs of Abuse - p. 354 25. Therapeutic Drug Monitoring - p. 364 26. Toxins and Acute Poisoning - p. 380 27. Conclusion - p. 386 28. Chapter 25. Evaluation of Endocrine Function - p. 387 29. Pituitary Function - p. 387 30. Thyroid Function - p. 395 31. Adrenal Function - p. 404 32. Renin-Aldosterone Axis - p. 420 33. Chapter 26. Reproductive Function and Pregnancy - p. 425 34. Chapter 27. Vitamins and Trace Elements - p. 441 35. Chapter 28. Chemical Basis for Analyte Assays and Common Interferences - p. 453 36. Part 3. Urine and Other Body Fluids - p. 466.e1 37. Chapter 29. Basic Examination of Urine - p. 468 38. Urine Formation - p. 468 39. Components of Basic (Routine) Urinalysis - p. 468 40. Methods For Urinalysis - p. 499 41. Special Testing And Monitoring Techniques - p. 505 42. Chapter 30. Cerebrospinal, Synovial, Serous Body Fluids, and Alternative Specimens - p. 510 43. Cerebrospinal Fluid - p. 510 44. Synovial Fluid - p. 522 45. Pleural Fluid - p. 527 46. Pericardial Fluid - p. 531 47. Peritoneal Fluid - p. 533 48. Alternative Specimens - p. 536 49. Chemical Measurements in Body Fluids - p. 537 50. Part 4. Hematology and Transfusion Medicine - p. 538.e6 51. Chapter 31. Basic Examination of Blood and Bone Marrow - p. 540 52. Chapter 32. Hematopoiesis - p. 570 53. Chapter 33. Erythrocytic Disorders - p. 588 54. Anemias - p. 588 55. Polycythemia - p. 630 56. The porphyrias - p. 631 57. Chapter 34. Leukocytic Disorders - p. 636 58. Leukocytes - p. 636 59. Nonneoplastic Disorders - p. 636 60. Neoplastic Disorders Primarily Involving Leukocytes - p. 646 61. Chapter 35. The Flow Cytometric Evaluation of Hematopoietic Neoplasia - p. 689 62. Chapter 36. Immunohematology - p. 708 63. Basic Immunohematologic Concepts - p. 708 64. Erythrocyte Antigens and Antibodies - p. 711 65. Immunohematology Tests And Procedures - p. 744 66. Positive Direct Antiglobulin Tests and Hemolytic Anemia Induced By Medication - p. 763 67. Granulocyte serology - p. 763 68. Platelet serology - p. 767 69. Chapter 37. Transfusion Medicine - p. 771 70. Chapter 38. Hemapheresis - p. 788 71. Introduction - p. 788 72. Donor Cytapheresis - p. 790 73. Donor Plasmapheresis - p. 798 74. Indications for Therapeutic Hemapheresis - p. 799 75. Donor/Patient Complications Common to All Hemapheresis Procedures - p. 811 76. Summary - p. 816 77. Chapter 39. Tissue Banking and Progenitor Cells - p. 817 78. Part 5. Hemostasis and Thrombosis - p. 826.e1 79. Chapter 40. Coagulation And Fibrinolysis - p. 828 80. Chapter 41. Platelet Disorders and Von Willebrand Disease - p. 847 81. Normal Platelet Biology - p. 847 82. Laboratory Evaluation of Platelet Disorders - p. 849 83. Quantitative Platelet Disorders - p. 852 84. Inherited Disorders of Platelet Function - p. 857 85. Acquired Disorders of Platelet Function - p. 862 86. Von Willebrand Factor, Von Willebrand Disease, and Thrombotic Thrombocytopenic Purpura - p. 864 87. Chapter 42. Laboratory Approach to Thrombotic Risk - p. 870 88. Chapter 43. Antithrombotic Therapy - p. 879 89. Part 6. Immunology and Immunopathology - p. 892.e2 90. Chapter 44. Overview of the Immune System and Immunologic Disorders - p. 894 91. Chapter 45. Immunoassays And Immunochemistry - p. 901 92. Chapter 46. Laboratory Evaluation of The Cellular Immune System - p. 929 93. General Principles of Cellular Immunology - p. 930 94. Flow and Image Cytometry In Evaluation Of Cellular Immunity - p. 933 95. Gating and Data Analysis - p. 936 96. Clinical Significance of Cellular Immune Testing - p. 939 97. Clinical Interpretation of Cellular Immune Testing - p. 939 98. Methodologic Approach to Cellular Immune Testing - p. 940 99. Laboratory Evaluation of Lymphocyte Function - p. 943 100. Laboratory Evaluation of Granulocyte And Monocyte Function - p. 946 101. Quality Control and Quality Assurance in the Cellular Laboratory - p. 949 102. Chapter 47. Laboratory Evaluation Of Immunoglobulin Function And Humoral Immunity - p. 952 103. Chapter 48. Mediators of Inflammation: Complement - p. 969 104. Chapter 49. Mediators of Inflammation: Cytokines and Adhesion Molecules - p. 984 105. Chapter 50. Human Leukocyte Antigen: The Major Histocompatibility Complex of Humans - p. 996 106. Chapter 51. The Major Histocompatibility Complex And Disease - p. 1014 107. Chapter 52. Immunodeficiency Disorders - p. 1025 108. Chapter 53. Clinical and Laboratory Evaluation of Systemic Autoimmune Rheumatic Diseases - p. 1035 109. Introduction and Classification of Systemic Autoimmune Rheumatic Diseases - p. 1035 110. Systemic Lupus Erythematosus and Related Lupus–Like Disorders - p. 1036 111. Sjögren Syndrome - p. 1040 112. Systemic Sclerosis - p. 1041 113. Rheumatoid Arthritis - p. 1044 114. Idiopathic Inflammatory Myopathies - p. 1046 115. Concept of Overlap Syndromes - p. 1049 116. Profiles of Autoantibodies in Various Systemic Rheumatic Diseases - p. 1049 117. Techniques Used To Detect Autoantibodies - p. 1049 118. Chapter 54. Vasculitis - p. 1058 119. Chapter 55. Organ-Specific Autoimmune Diseases - p. 1074 120. Introduction and Overview to the Organ-Specific Autoimmune Diseases - p. 1074 121. Cutaneous Autoimmune Diseases - p. 1079 122. Gastrointestinal and Hepatobiliary Autoimmune Diseases - p. 1084 123. Glomerular Autoimmune Diseases - p. 1089 124. Immunoendocrinopathies - p. 1108 125. Autoimmune Diseases of the Neuromuscular Junction, Nervous System, and Muscle - p. 1112 126. Conclusion - p. 1113 127. Chapter 56. Allergic Diseases - p. 1115 128. Part 7. Medical Microbiology - p. 1128.e2 129. Chapter 57. Medical Bacteriology - p. 1130 130. Specimen Processing - p. 1130 131. Medically Important Bacteria - p. 1131 132. Chapter 58. In Vitro Testing of Antimicrobial Agents - p. 1166 133. Chapter 59. Mycobacteria - p. 1183 134. Chapter 60. Mycotic Diseases - p. 1194 135. Nomenclature, Taxonomy, and Fungal Morphology - p. 1195 136. Diagnostic Techniques - p. 1200 137. Candidiasis, Cryptococcosis, and Other Infections Caused by Yeast - p. 1207 138. Mycoses Caused by Dimorphic Fungi - p. 1211 139. Dermatophytoses - p. 1216 140. Mycoses Caused by Dematiaceous (Melanized) Fungi - p. 1219 141. Mucormycosis (Zygomycosis) - p. 1220 142. Aspergillosis, Fusariosis, and Other Mycoses Caused by Hyaline Fungi - p. 1222 143. Microsporidiosis - p. 1225 144. Pneumocystis Pneumonia - p. 1226 145. Protothecosis - p. 1227 146. Chapter 61. Spirochete Infections - p. 1229 147. Chapter 62. Chlamydial And Mycoplasmal Infections - p. 1246 148. Chapter 63. Rickettsiae and Other Related Intracellular Bacteria - p. 1254 149. Chapter 64. Viral Infections - p. 1266 150. Introduction - p. 1266 151. Clinical Viral Infectious Syndromes - p. 1266 152. Summary - p. 1289 153. Chapter 65. Medical Parasitology - p. 1290 154. Parasite Classification and Taxonomy - p. 1292 155. Laboratory Methods - p. 1292 156. Blood and Tissue Protozoa - p. 1301 157. Intestinal Helminths - p. 1326 158. Tissue Helminths - p. 1338 159. Medically Important Arthropods - p. 1344 160. Parasitic Infections and the Immunocompromised Host - p. 1351 161. Chapter 66. Specimen Collection and Handling for Diagnosis of Infectious Diseases - p. 1352 162. Part 8. Molecular Pathology - p. 1366.e2 163. 67. Introduction To Molecular Pathology - p. 1368 164. Chapter 68. Molecular Diagnostics: Basic Principles And Techniques - p. 1373 165. Chapter 69. Polymerase Chain Reaction And Other Nucleic Acid Amplification Technology - p. 1387 166. Chapter 70. Hybridization Array Technologies - p. 1401 167. 71. Applications of Cytogenetics in Modern Pathology - p. 1411 168. 72. Molecular Diagnosis of Genetic Diseases - p. 1434 169. Chapter 73. Molecular Genetics of Neuropsychiatric Disorders: Current Research and Perspectives - p. 1452 170. Chapter 74. Identity Testing: Use of Dna Analysis In Parentage, Forensic, And Missing Persons Testing - p. 1468 171. Chapter 75. Pharmacogenomics and Personalized Medicine - p. 1480 172. Overview - p. 1480 173. Basic Concepts - p. 1480 174. Drug-Metabolizing Enzyme Pharmacogenomics - p. 1481 175. Drug-Transporter Pharmacogenomics - p. 1486 176. Drug Target Pharmacogenomics - p. 1489 177. Human Leukocyte Antigen Pharmacogenomics - p. 1495 178. Pharmacogenomics In Cancer Chemotherapy - p. 1496 179. Pharmacogenomics in Other Diseases - p. 1501 180. Conclusion - p. 1504 181. Part 9. Clinical Pathology of Cancer - p. 1506.e6 182. Chapter 76. Diagnosis and Management of Cancer Using Serologic and Other Body Fluid Markers - p. 1508 183. Chapter 77. Oncoproteins And Early Tumor Detection - p. 1525 184. Chapter 78. Molecular Diagnosis of Hematopoietic Neoplasms - p. 1542 185. Molecular Diagnosis of Lymphoid Neoplasms - p. 1543 186. Molecular Diagnosis of Myeloid Neoplasms - p. 1556 187. Chapter 79. Molecular Genetic Pathology Of Solid Tumors - p. 1579 188. Molecular Genetic Pathology of Specific Solid Tumors By Major Organ - p. 1580 189. Molecular Genetic Pathology of Sarcoma - p. 1599 190. Molecular Genetic Pathology of Multiple Endocrine Neoplasia - p. 1602 191. Cancers of Unknown Origin - p. 1604 192. Clinical Application of Next-Generation Sequencing - p. 1604 193. 80. High-Throughput Genomic and Proteomic Technologies in the Postgenomic Era - p. 1607 194. Appendix 1. Physiologic Solutions, Buffers, Acid-Base Indicators, Standard Reference Materials, and Temperature Conversions - p. 1623.e3 195. Appendix 2. Desirable Weights, Body Surface Area, and Body Mass Index - p. 1623.e7 196. Appendix 3. Approximations of Total Blood Volume - p. 1623.e11 197. Appendix 4. Periodic Table of the Elements - p. 1623.e12 198. Appendix 5. SI Units - p. 1623.e14 199. Appendix 6. Common Chimeric Genes Identified in Human Malignancies - p. 1623.e32 200. Appendix 7. Disease/Organ Panels - p. 1623.e36 201. Index - p. 1624 202. Guidelines for Ordering Blood for Elective Surgery - p. 1665
For more than 100 years, Henry's Clinical Diagnosis and Management by Laboratory Methods has been recognized as the premier text in clinical laboratory medicine, widely used by both clinical pathologists and laboratory technicians. Leading experts in each testing discipline clearly explain procedures and how they are used both to formulate clinical diagnoses and to plan patient medical care and long-term management. Employing a multidisciplinary approach, it provides cutting-edge coverage of automation, informatics, molecular diagnostics, proteomics, laboratory management, and quality control, emphasizing new testing methodologies throughout.
1. Introduction - p. 182 2. Volumes And Osmolality Of Body Fluid - p. 182 3. Regulation Of Extracellular Volume - p. 186 4. Measurement Of Renal Function - p. 187 5. Biomarkers Of Acute Kidney Injury (AKI) - p. 192 6. Disorders Of Potassium - p. 193 7. Disorders Of Water, Sodium, And Antidiuretic Hormone (ADH) Metabolism - p. 197 8. Acid-Base Disorders - p. 201 9. Chapter 16. Biochemical Markers Of Bone Metabolism - p. 208 10. Chapter 17. Carbohydrates - p. 225 11. CHAPTER 18. Lipids And Dyslipoproteinemia - p. 244 12. Chapter 19. Cardiac Injury, Atherosclerosis, And Thrombotic Disease - p. 267 13. Chapter 20. Specific Proteins - p. 276 14. Chapter 21. Clinical Enzymology - p. 291 15. General Properties of Enzymes - p. 291 16. Enzyme Kinetics: Determination Of Total Enzyme Concentrations In Serum And Other Body Fluids - p. 295 17. Inhibition of Enzymes - p. 300 18. Catalytic Efficiency: Transition State Theory And Drug Design - p. 302 19. Specific Enzymes - p. 305 20. Chapter 22. Evaluation Of Liver Function - p. 314 21. Chapter 23. Laboratory Diagnosis of Gastrointestinal and Pancreatic Disorders - p. 331 22. Chapter 24. Toxicology and Therapeutic Drug Monitoring - p. 347 23. Basic Techniques for Detecting Drugs in Serum and Urine - p. 347 24. The Drugs of Abuse - p. 354 25. Therapeutic Drug Monitoring - p. 364 26. Toxins and Acute Poisoning - p. 380 27. Conclusion - p. 386 28. Chapter 25. Evaluation of Endocrine Function - p. 387 29. Pituitary Function - p. 387 30. Thyroid Function - p. 395 31. Adrenal Function - p. 404 32. Renin-Aldosterone Axis - p. 420 33. Chapter 26. Reproductive Function and Pregnancy - p. 425 34. Chapter 27. Vitamins and Trace Elements - p. 441 35. Chapter 28. Chemical Basis for Analyte Assays and Common Interferences - p. 453 36. Part 3. Urine and Other Body Fluids - p. 466.e1 37. Chapter 29. Basic Examination of Urine - p. 468 38. Urine Formation - p. 468 39. Components of Basic (Routine) Urinalysis - p. 468 40. Methods For Urinalysis - p. 499 41. Special Testing And Monitoring Techniques - p. 505 42. Chapter 30. Cerebrospinal, Synovial, Serous Body Fluids, and Alternative Specimens - p. 510 43. Cerebrospinal Fluid - p. 510 44. Synovial Fluid - p. 522 45. Pleural Fluid - p. 527 46. Pericardial Fluid - p. 531 47. Peritoneal Fluid - p. 533 48. Alternative Specimens - p. 536 49. Chemical Measurements in Body Fluids - p. 537 50. Part 4. Hematology and Transfusion Medicine - p. 538.e6 51. Chapter 31. Basic Examination of Blood and Bone Marrow - p. 540 52. Chapter 32. Hematopoiesis - p. 570 53. Chapter 33. Erythrocytic Disorders - p. 588 54. Anemias - p. 588 55. Polycythemia - p. 630 56. The porphyrias - p. 631 57. Chapter 34. Leukocytic Disorders - p. 636 58. Leukocytes - p. 636 59. Nonneoplastic Disorders - p. 636 60. Neoplastic Disorders Primarily Involving Leukocytes - p. 646 61. Chapter 35. The Flow Cytometric Evaluation of Hematopoietic Neoplasia - p. 689 62. Chapter 36. Immunohematology - p. 708 63. Basic Immunohematologic Concepts - p. 708 64. Erythrocyte Antigens and Antibodies - p. 711 65. Immunohematology Tests And Procedures - p. 744 66. Positive Direct Antiglobulin Tests and Hemolytic Anemia Induced By Medication - p. 763 67. Granulocyte serology - p. 763 68. Platelet serology - p. 767 69. Chapter 37. Transfusion Medicine - p. 771 70. Chapter 38. Hemapheresis - p. 788 71. Introduction - p. 788 72. Donor Cytapheresis - p. 790 73. Donor Plasmapheresis - p. 798 74. Indications for Therapeutic Hemapheresis - p. 799 75. Donor/Patient Complications Common to All Hemapheresis Procedures - p. 811 76. Summary - p. 816 77. Chapter 39. Tissue Banking and Progenitor Cells - p. 817 78. Part 5. Hemostasis and Thrombosis - p. 826.e1 79. Chapter 40. Coagulation And Fibrinolysis - p. 828 80. Chapter 41. Platelet Disorders and Von Willebrand Disease - p. 847 81. Normal Platelet Biology - p. 847 82. Laboratory Evaluation of Platelet Disorders - p. 849 83. Quantitative Platelet Disorders - p. 852 84. Inherited Disorders of Platelet Function - p. 857 85. Acquired Disorders of Platelet Function - p. 862 86. Von Willebrand Factor, Von Willebrand Disease, and Thrombotic Thrombocytopenic Purpura - p. 864 87. Chapter 42. Laboratory Approach to Thrombotic Risk - p. 870 88. Chapter 43. Antithrombotic Therapy - p. 879 89. Part 6. Immunology and Immunopathology - p. 892.e2 90. Chapter 44. Overview of the Immune System and Immunologic Disorders - p. 894 91. Chapter 45. Immunoassays And Immunochemistry - p. 901 92. Chapter 46. Laboratory Evaluation of The Cellular Immune System - p. 929 93. General Principles of Cellular Immunology - p. 930 94. Flow and Image Cytometry In Evaluation Of Cellular Immunity - p. 933 95. Gating and Data Analysis - p. 936 96. Clinical Significance of Cellular Immune Testing - p. 939 97. Clinical Interpretation of Cellular Immune Testing - p. 939 98. Methodologic Approach to Cellular Immune Testing - p. 940 99. Laboratory Evaluation of Lymphocyte Function - p. 943 100. Laboratory Evaluation of Granulocyte And Monocyte Function - p. 946 101. Quality Control and Quality Assurance in the Cellular Laboratory - p. 949 102. Chapter 47. Laboratory Evaluation Of Immunoglobulin Function And Humoral Immunity - p. 952 103. Chapter 48. Mediators of Inflammation: Complement - p. 969 104. Chapter 49. Mediators of Inflammation: Cytokines and Adhesion Molecules - p. 984 105. Chapter 50. Human Leukocyte Antigen: The Major Histocompatibility Complex of Humans - p. 996 106. Chapter 51. The Major Histocompatibility Complex And Disease - p. 1014 107. Chapter 52. Immunodeficiency Disorders - p. 1025 108. Chapter 53. Clinical and Laboratory Evaluation of Systemic Autoimmune Rheumatic Diseases - p. 1035 109. Introduction and Classification of Systemic Autoimmune Rheumatic Diseases - p. 1035 110. Systemic Lupus Erythematosus and Related Lupus–Like Disorders - p. 1036 111. Sjögren Syndrome - p. 1040 112. Systemic Sclerosis - p. 1041 113. Rheumatoid Arthritis - p. 1044 114. Idiopathic Inflammatory Myopathies - p. 1046 115. Concept of Overlap Syndromes - p. 1049 116. Profiles of Autoantibodies in Various Systemic Rheumatic Diseases - p. 1049 117. Techniques Used To Detect Autoantibodies - p. 1049 118. Chapter 54. Vasculitis - p. 1058 119. Chapter 55. Organ-Specific Autoimmune Diseases - p. 1074 120. Introduction and Overview to the Organ-Specific Autoimmune Diseases - p. 1074 121. Cutaneous Autoimmune Diseases - p. 1079 122. Gastrointestinal and Hepatobiliary Autoimmune Diseases - p. 1084 123. Glomerular Autoimmune Diseases - p. 1089 124. Immunoendocrinopathies - p. 1108 125. Autoimmune Diseases of the Neuromuscular Junction, Nervous System, and Muscle - p. 1112 126. Conclusion - p. 1113 127. Chapter 56. Allergic Diseases - p. 1115 128. Part 7. Medical Microbiology - p. 1128.e2 129. Chapter 57. Medical Bacteriology - p. 1130 130. Specimen Processing - p. 1130 131. Medically Important Bacteria - p. 1131 132. Chapter 58. In Vitro Testing of Antimicrobial Agents - p. 1166 133. Chapter 59. Mycobacteria - p. 1183 134. Chapter 60. Mycotic Diseases - p. 1194 135. Nomenclature, Taxonomy, and Fungal Morphology - p. 1195 136. Diagnostic Techniques - p. 1200 137. Candidiasis, Cryptococcosis, and Other Infections Caused by Yeast - p. 1207 138. Mycoses Caused by Dimorphic Fungi - p. 1211 139. Dermatophytoses - p. 1216 140. Mycoses Caused by Dematiaceous (Melanized) Fungi - p. 1219 141. Mucormycosis (Zygomycosis) - p. 1220 142. Aspergillosis, Fusariosis, and Other Mycoses Caused by Hyaline Fungi - p. 1222 143. Microsporidiosis - p. 1225 144. Pneumocystis Pneumonia - p. 1226 145. Protothecosis - p. 1227 146. Chapter 61. Spirochete Infections - p. 1229 147. Chapter 62. Chlamydial And Mycoplasmal Infections - p. 1246 148. Chapter 63. Rickettsiae and Other Related Intracellular Bacteria - p. 1254 149. Chapter 64. Viral Infections - p. 1266 150. Introduction - p. 1266 151. Clinical Viral Infectious Syndromes - p. 1266 152. Summary - p. 1289 153. Chapter 65. Medical Parasitology - p. 1290 154. Parasite Classification and Taxonomy - p. 1292 155. Laboratory Methods - p. 1292 156. Blood and Tissue Protozoa - p. 1301 157. Intestinal Helminths - p. 1326 158. Tissue Helminths - p. 1338 159. Medically Important Arthropods - p. 1344 160. Parasitic Infections and the Immunocompromised Host - p. 1351 161. Chapter 66. Specimen Collection and Handling for Diagnosis of Infectious Diseases - p. 1352 162. Part 8. Molecular Pathology - p. 1366.e2 163. 67. Introduction To Molecular Pathology - p. 1368 164. Chapter 68. Molecular Diagnostics: Basic Principles And Techniques - p. 1373 165. Chapter 69. Polymerase Chain Reaction And Other Nucleic Acid Amplification Technology - p. 1387 166. Chapter 70. Hybridization Array Technologies - p. 1401 167. 71. Applications of Cytogenetics in Modern Pathology - p. 1411 168. 72. Molecular Diagnosis of Genetic Diseases - p. 1434 169. Chapter 73. Molecular Genetics of Neuropsychiatric Disorders: Current Research and Perspectives - p. 1452 170. Chapter 74. Identity Testing: Use of Dna Analysis In Parentage, Forensic, And Missing Persons Testing - p. 1468 171. Chapter 75. Pharmacogenomics and Personalized Medicine - p. 1480 172. Overview - p. 1480 173. Basic Concepts - p. 1480 174. Drug-Metabolizing Enzyme Pharmacogenomics - p. 1481 175. Drug-Transporter Pharmacogenomics - p. 1486 176. Drug Target Pharmacogenomics - p. 1489 177. Human Leukocyte Antigen Pharmacogenomics - p. 1495 178. Pharmacogenomics In Cancer Chemotherapy - p. 1496 179. Pharmacogenomics in Other Diseases - p. 1501 180. Conclusion - p. 1504 181. Part 9. Clinical Pathology of Cancer - p. 1506.e6 182. Chapter 76. Diagnosis and Management of Cancer Using Serologic and Other Body Fluid Markers - p. 1508 183. Chapter 77. Oncoproteins And Early Tumor Detection - p. 1525 184. Chapter 78. Molecular Diagnosis of Hematopoietic Neoplasms - p. 1542 185. Molecular Diagnosis of Lymphoid Neoplasms - p. 1543 186. Molecular Diagnosis of Myeloid Neoplasms - p. 1556 187. Chapter 79. Molecular Genetic Pathology Of Solid Tumors - p. 1579 188. Molecular Genetic Pathology of Specific Solid Tumors By Major Organ - p. 1580 189. Molecular Genetic Pathology of Sarcoma - p. 1599 190. Molecular Genetic Pathology of Multiple Endocrine Neoplasia - p. 1602 191. Cancers of Unknown Origin - p. 1604 192. Clinical Application of Next-Generation Sequencing - p. 1604 193. 80. High-Throughput Genomic and Proteomic Technologies in the Postgenomic Era - p. 1607 194. Appendix 1. Physiologic Solutions, Buffers, Acid-Base Indicators, Standard Reference Materials, and Temperature Conversions - p. 1623.e3 195. Appendix 2. Desirable Weights, Body Surface Area, and Body Mass Index - p. 1623.e7 196. Appendix 3. Approximations of Total Blood Volume - p. 1623.e11 197. Appendix 4. Periodic Table of the Elements - p. 1623.e12 198. Appendix 5. SI Units - p. 1623.e14 199. Appendix 6. Common Chimeric Genes Identified in Human Malignancies - p. 1623.e32 200. Appendix 7. Disease/Organ Panels - p. 1623.e36 201. Index - p. 1624 202. Guidelines for Ordering Blood for Elective Surgery - p. 1665
