Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies.
This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more.
Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques.
1. Principles of Human Organs-on-Chips - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. Foreword - p. Page viii 8. Preface - p. Page x 9. List of Illustrations - p. Page xi 10. List of Tables - p. Page xii 11. Chapter 1 : Techniques and materials for the fabrication of microfluidic devices - p. Page xii 12. Chapter 2 : Critical factors affecting cells behavior in microfluidic chips - p. Page 28 13. Chapter 3 : Cell-based assays on microfluidic chips - p. Page 52 14. Chapter 4 : Cell culture techniques in microfluidic chips - p. Page 79 15. Chapter 5 : Advances in skin-on-a-chip and skin tissue engineering - p. Page 116 16. Chapter 6 : Blood vessels-on-a-chip - p. Page 155 17. Chapter 7 : Liver-on-a-chip - p. Page 189 18. Chapter 8 : Lung-on-a-chip - p. Page 236 19. Chapter 9 : Kidney-on-a-chip - p. Page 267 20. Chapter 10 : Eye-on-a-chip - p. Page 304 21. Chapter 11 : Pancreas-on-a-chip - p. Page 352 22. Chapter 12 : Musculoskeletal tissue-on-a-chip - p. Page 400 23. Chapter 13 : Tumour-on-a-chip - p. Page 423 24. Index - p. Page 454
Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies.
This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more.
Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques.
1. Principles of Human Organs-on-Chips - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. Foreword - p. Page viii 8. Preface - p. Page x 9. List of Illustrations - p. Page xi 10. List of Tables - p. Page xii 11. Chapter 1 : Techniques and materials for the fabrication of microfluidic devices - p. Page xii 12. Chapter 2 : Critical factors affecting cells behavior in microfluidic chips - p. Page 28 13. Chapter 3 : Cell-based assays on microfluidic chips - p. Page 52 14. Chapter 4 : Cell culture techniques in microfluidic chips - p. Page 79 15. Chapter 5 : Advances in skin-on-a-chip and skin tissue engineering - p. Page 116 16. Chapter 6 : Blood vessels-on-a-chip - p. Page 155 17. Chapter 7 : Liver-on-a-chip - p. Page 189 18. Chapter 8 : Lung-on-a-chip - p. Page 236 19. Chapter 9 : Kidney-on-a-chip - p. Page 267 20. Chapter 10 : Eye-on-a-chip - p. Page 304 21. Chapter 11 : Pancreas-on-a-chip - p. Page 352 22. Chapter 12 : Musculoskeletal tissue-on-a-chip - p. Page 400 23. Chapter 13 : Tumour-on-a-chip - p. Page 423 24. Index - p. Page 454
