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Because of the complex range of factors to be considered in pscyhosis –genetic, neurologic, biologic, environmental, family, culture - this issue of Child and Adolescent Psychiatric Clinics presents aspects that have the greatest relevance and impact in diagnosing and treating child and adolescent patients. Among some of the topics covered: Schizophrenia, Affective disorders and Psychosis, Comorbid diseases, Neurocognition, Genetics, Neuroimaging findings, and Treatment approaches of Psychopharmacology, Psychotherapy, and Community Rehabilitation. Jean Frazier, an expert in child and adolescent neuropsychiatry and in child psychopharmacology, leads this issue along with Yael Dvir, whose research and clinical interests include childhood psychosis and the associations between childhood psychosis and Autistic Spectrum Disorders.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 6 6. Psychotic Disorders in Youth: Diagnostic and Treatment Challenges - p. 7 7. Section 1: Clinical Presentations of Psychosis - p. 8 8. Childhood Onset Schizophrenia and Early Onset Schizophrenia Spectrum Disorders - p. 9 9. The Prodrome and Clinical Risk for Psychotic Disorders - p. 17 10. Affective Disorders and Psychosis in Youth - p. 24 11. Congenital and Acquired Disorders Presenting as Psychosis in Children and Young Adults - p. 32 12. Section 2: Differential Diagnosis and Comorbidities in Psychosis - p. 43 13. “Autism-plus” Spectrum Disorders - p. 44 14. Childhood Trauma and Psychosis - p. 55 15. Substance Abuse and Psychosis - p. 63 16. Section 3: Early Onset Psychosis Etiologies and Biomarkers - p. 69 17. Diagnosis and Evaluation of Hallucinations and Other Psychotic Symptoms in Children and Adolescents - p. 70 18. Genetics of Childhood-onset Schizophrenia - p. 77 19. Gray Matter Alterations in Schizophrenia High-Risk Youth and Early-Onset Schizophrenia - p. 84 20. Neurocognition in Early-Onset Schizophrenia - p. 96 21. Section 4: Evidence Based Interventions for Psychosis - p. 103 22. Psychopharmacologic Treatment of Psychosis in Children and Adolescents - p. 104 23. Community Rehabilitation and Psychosocial Interventions for Psychotic Disorders in Youth - p. 112 24. Index - p. 121

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Because of the complex range of factors to be considered in pscyhosis –genetic, neurologic, biologic, environmental, family, culture - this issue of Child and Adolescent Psychiatric Clinics presents aspects that have the greatest relevance and impact in diagnosing and treating child and adolescent patients. Among some of the topics covered: Schizophrenia, Affective disorders and Psychosis, Comorbid diseases, Neurocognition, Genetics, Neuroimaging findings, and Treatment approaches of Psychopharmacology, Psychotherapy, and Community Rehabilitation. Jean Frazier, an expert in child and adolescent neuropsychiatry and in child psychopharmacology, leads this issue along with Yael Dvir, whose research and clinical interests include childhood psychosis and the associations between childhood psychosis and Autistic Spectrum Disorders.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 6 6. Psychotic Disorders in Youth: Diagnostic and Treatment Challenges - p. 7 7. Section 1: Clinical Presentations of Psychosis - p. 8 8. Childhood Onset Schizophrenia and Early Onset Schizophrenia Spectrum Disorders - p. 9 9. The Prodrome and Clinical Risk for Psychotic Disorders - p. 17 10. Affective Disorders and Psychosis in Youth - p. 24 11. Congenital and Acquired Disorders Presenting as Psychosis in Children and Young Adults - p. 32 12. Section 2: Differential Diagnosis and Comorbidities in Psychosis - p. 43 13. “Autism-plus” Spectrum Disorders - p. 44 14. Childhood Trauma and Psychosis - p. 55 15. Substance Abuse and Psychosis - p. 63 16. Section 3: Early Onset Psychosis Etiologies and Biomarkers - p. 69 17. Diagnosis and Evaluation of Hallucinations and Other Psychotic Symptoms in Children and Adolescents - p. 70 18. Genetics of Childhood-onset Schizophrenia - p. 77 19. Gray Matter Alterations in Schizophrenia High-Risk Youth and Early-Onset Schizophrenia - p. 84 20. Neurocognition in Early-Onset Schizophrenia - p. 96 21. Section 4: Evidence Based Interventions for Psychosis - p. 103 22. Psychopharmacologic Treatment of Psychosis in Children and Adolescents - p. 104 23. Community Rehabilitation and Psychosocial Interventions for Psychotic Disorders in Youth - p. 112 24. Index - p. 121

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