Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field— all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases.
Covers the epidemiology, pathogenesis, clinical manifestations, therapeutic approach, and management of all major as well as rarely encountered rheumatic and musculoskeletal diseases.
Discusses clinical examination, imaging principles, differential diagnosis, established and novel therapies, perioperative evaluation, pain management, basic science, and genetics of rheumatic and musculoskeletal diseases.
Uses a consistent, logical, reader-friendly format with templated chapters, concise text, and large-scale, state-of-the-art illustrations for efficient visual reference.
Contains new chapters covering pre-clinical disease and how to address these patients, common comorbidities in rheumatoid arthritis; emerging therapies for systemic sclerosis; immune mediated complications of checkpoint inhibitors; the epidemiology of COVID-19 and rheumatic and musculoskeletal diseases, emerging treatments for osteoarthritis, and big data analytics.
Provides updates to key topics such as systems biology and its impact on our understanding of the pathogenesis of rheumatic and musculoskeletal diseases, the microbiome in rheumatic musculoskeletal diseases, how to manage chronic pain in the patient with a rheumatic disease, drugs and reproductive health, and emerging therapies for patients with RA, SLE, spondyloarthritis, inflammatory muscle disease, and vasculitis.
Shares the knowledge and expertise of numerous new contributing authors, as well as new co-editor Dr. Désirée van der Heijde, who is an expert in psoriatic arthritis, spondyloarthritis, imaging, and clinical epidemiology.
Provides access to concise videos depicting the use of ultrasound for diagnosis and treatment.
1. Introduction - p. 1519 2. The Hereditary Episodic Fever Syndromes - p. 1519 3. Neutrophilic Urticaria (The Cryopyrin-Associated Periodic Syndrome, Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, And Neonatal-Onset Multisystem Inflammatory Disease) - p. 1529 4. Variable Rashes, High Serum Interleukin-18, and Variable Predisposition to Macrophage Activation Syndrome - p. 1531 5. NLRP1-Associated Autoinflammation with Arthritis and Dyskeratosis - p. 1532 6. Pustular Skin Rashes and Episodic Fevers - p. 1532 7. Partially Interleukin-1–Mediated Pyogenic Disorders - p. 1533 8. Pyogenic Disorders Caused by Non–Interleukin-1 Cytokine Dysregulation - p. 1534 9. Vasculopathy and Panniculitis/Lipoatrophy Syndromes - p. 1536 10. Vasculopathy and/or Vasculitis with Livedo Reticularis Syndromes - p. 1537 11. Autoinflammatory Disorders with Granulomatous Skin Diseases - p. 1539 12. Other Autoinflammatory Syndromes - p. 1540 13. Syndromes Presenting with a Wider Clinical Phenotype - p. 1541 14. Acknowledgment - p. 1541 15. References - p. 1541 16. 175. Sarcoidosis - p. 1547 17. 176. Relapsing polychondritis - p. 1557 18. 177. The systemic amyloidoses - p. 1562 19. 178. IgG4-related disease - p. 1572 20. 179. Immune-mediated complications of checkpoint inhibitors - p. 1582 21. 180. The epidemiology of coronavirus disease 2019 (COVID-19) and rheumatic disease - p. 1589 22. Section 16: Osteoarthritis - p. 1593 23. 181. Epidemiology and classification of osteoarthritis - p. 1595 24. 182. Local and systemic risk factors for incidence and progression of osteoarthritis - p. 1605 25. 183. Clinical features of osteoarthritis - p. 1614 26. 184. Animal models of osteoarthritis - p. 1620 27. 185. Pathogenesis and pathology of osteoarthritis - p. 1628 28. 186. Genetics and epigenetics of osteoarthritis - p. 1645 29. 187. Imaging of osteoarthritis - p. 1652 30. 188. Assessment of the patient with osteoarthritis and measurement of outcomes - p. 1667 31. 189. Preclinical and early osteoarthritis - p. 1673 32. 190. Management of osteoarthritis - p. 1679 33. 191. Emerging treatments for osteoarthritis - p. 1684 34. Section 17: Crystal-Related Arthropathies - p. 1689 35. 192. Epidemiology and classification of gout - p. 1693 36. 193. Etiology and pathogenesis of gout - p. 1700 37. 194. Clinical features of gout - p. 1713 38. 195. Management of gout and hyperuricemia - p. 1716 39. 196. Calcium pyrophosphate deposition disease (pseudogout) - p. 1724 40. 197. Basic calcium phosphate crystal deposition disease - p. 1735 41. Section 18: Metabolic Bone Disease - p. 1741 42. 198. Epidemiology and classification of osteoporosis - p. 1743 43. 199. Clinical evaluation and clinical features of osteoporosis - p. 1752 44. 200. Pathophysiology of osteoporosis - p. 1760 45. 201. Biochemical markers of bone turnover in postmenopausal osteoporosis - p. 1765 46. 202. Management of osteoporosis - p. 1774 47. 203. Glucocorticoid-induced osteoporosis - p. 1788 48. 204. Osteomalacia, rickets, and renal osteodystrophy - p. 1796 49. 205. Paget disease of bone - p. 1803 50. Section 19: Other Arthropathies and Miscellaneous Disorders - p. 1810 51. 206. Diffuse idiopathic skeletal hyperostosis - p. 1811 52. 207. Neuropathic arthropathy - p. 1818 53. 208. Osteonecrosis - p. 1824 54. 209. Rheumatoid manifestations of endocrine and metabolic diseases and treatments - p. 1833 55. 210. Hemophilia-associated arthritis - p. 1840 56. 211. Rheumatologic manifestations of hemoglobinopathies - p. 1848 57. 212. Hemochromatosis - p. 1853 58. 213. Gaucher disease - p. 1857 59. 214. Digital clubbing and hypertrophic osteoarthropathy - p. 1863 60. 215. Miscellaneous arthropathies - p. 1868 61. 216. Heritable connective tissue disorders - p. 1882 62. 217. Hypermobility syndrome - p. 1902 63. 218. Bone tumors - p. 1907.e1 64. Appendix:. Classification and Diagnostic Criteria - p. 1907.e17 65. Acute Rheumatic Fever - p. 1907.e19 66. Adult-Onset Still Disease - p. 1907.e20 67. Antiphospholipid Syndrome - p. 1907.e21 68. Complex Regional Pain Syndrome - p. 1907.e22 69. Diffuse Idiopathic Skeletal Hyperostosis - p. 1907.e23 70. Fibromyalgia - p. 1907.e23 71. Gout - p. 1907.e25 72. Hypermobility - p. 1907.e26 73. Igg4-Related Disease - p. 1907.e28 74. Inflammatory Muscle Disease - p. 1907.e29 75. Juvenile Idiopathic Arthritis - p. 1907.e34 76. Kashin-Beck Disease - p. 1907.e35 77. Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis - p. 1907.e35 78. Osteoarthritis - p. 1907.e36 79. Psoriatic Arthritis - p. 1907.e37 80. Reactive Arthritis - p. 1907.e38 81. Relapsing Polychondritis - p. 1907.e38 82. Rheumatoid Arthritis - p. 1907.e39 83. Sjögren Syndrome - p. 1907.e39 84. Spondyloarthritis - p. 1907.e40 85. Systemic Lupus Erythematosus - p. 1907.e43 86. Systemic Sclerosis And Scleroderma - p. 1907.e48 87. Vasculitis - p. 1907.e49 88. Index - p. 1907.e65 89. Rheumatic Disease Clinics - p. 1907.e65
Covering both the scientific basis of rheumatology and practical, clinical information for rheumatologists and trainees, Rheumatology, 8th Edition, remains a leading text in this fast-changing field. Dr. Marc Hochberg and his team of worldwide editors and authors keep you abreast of recent advances in the field— all in a user-friendly, accessible manner. Fully updated from cover to cover, this two-volume text is designed to meet the needs of all practicing and academic rheumatologists as well as arthritis-related health care professionals and scientists interested in rheumatic and musculoskeletal diseases.
Covers the epidemiology, pathogenesis, clinical manifestations, therapeutic approach, and management of all major as well as rarely encountered rheumatic and musculoskeletal diseases.
Discusses clinical examination, imaging principles, differential diagnosis, established and novel therapies, perioperative evaluation, pain management, basic science, and genetics of rheumatic and musculoskeletal diseases.
Uses a consistent, logical, reader-friendly format with templated chapters, concise text, and large-scale, state-of-the-art illustrations for efficient visual reference.
Contains new chapters covering pre-clinical disease and how to address these patients, common comorbidities in rheumatoid arthritis; emerging therapies for systemic sclerosis; immune mediated complications of checkpoint inhibitors; the epidemiology of COVID-19 and rheumatic and musculoskeletal diseases, emerging treatments for osteoarthritis, and big data analytics.
Provides updates to key topics such as systems biology and its impact on our understanding of the pathogenesis of rheumatic and musculoskeletal diseases, the microbiome in rheumatic musculoskeletal diseases, how to manage chronic pain in the patient with a rheumatic disease, drugs and reproductive health, and emerging therapies for patients with RA, SLE, spondyloarthritis, inflammatory muscle disease, and vasculitis.
Shares the knowledge and expertise of numerous new contributing authors, as well as new co-editor Dr. Désirée van der Heijde, who is an expert in psoriatic arthritis, spondyloarthritis, imaging, and clinical epidemiology.
Provides access to concise videos depicting the use of ultrasound for diagnosis and treatment.
1. Introduction - p. 1519 2. The Hereditary Episodic Fever Syndromes - p. 1519 3. Neutrophilic Urticaria (The Cryopyrin-Associated Periodic Syndrome, Familial Cold Autoinflammatory Syndrome, Muckle-Wells Syndrome, And Neonatal-Onset Multisystem Inflammatory Disease) - p. 1529 4. Variable Rashes, High Serum Interleukin-18, and Variable Predisposition to Macrophage Activation Syndrome - p. 1531 5. NLRP1-Associated Autoinflammation with Arthritis and Dyskeratosis - p. 1532 6. Pustular Skin Rashes and Episodic Fevers - p. 1532 7. Partially Interleukin-1–Mediated Pyogenic Disorders - p. 1533 8. Pyogenic Disorders Caused by Non–Interleukin-1 Cytokine Dysregulation - p. 1534 9. Vasculopathy and Panniculitis/Lipoatrophy Syndromes - p. 1536 10. Vasculopathy and/or Vasculitis with Livedo Reticularis Syndromes - p. 1537 11. Autoinflammatory Disorders with Granulomatous Skin Diseases - p. 1539 12. Other Autoinflammatory Syndromes - p. 1540 13. Syndromes Presenting with a Wider Clinical Phenotype - p. 1541 14. Acknowledgment - p. 1541 15. References - p. 1541 16. 175. Sarcoidosis - p. 1547 17. 176. Relapsing polychondritis - p. 1557 18. 177. The systemic amyloidoses - p. 1562 19. 178. IgG4-related disease - p. 1572 20. 179. Immune-mediated complications of checkpoint inhibitors - p. 1582 21. 180. The epidemiology of coronavirus disease 2019 (COVID-19) and rheumatic disease - p. 1589 22. Section 16: Osteoarthritis - p. 1593 23. 181. Epidemiology and classification of osteoarthritis - p. 1595 24. 182. Local and systemic risk factors for incidence and progression of osteoarthritis - p. 1605 25. 183. Clinical features of osteoarthritis - p. 1614 26. 184. Animal models of osteoarthritis - p. 1620 27. 185. Pathogenesis and pathology of osteoarthritis - p. 1628 28. 186. Genetics and epigenetics of osteoarthritis - p. 1645 29. 187. Imaging of osteoarthritis - p. 1652 30. 188. Assessment of the patient with osteoarthritis and measurement of outcomes - p. 1667 31. 189. Preclinical and early osteoarthritis - p. 1673 32. 190. Management of osteoarthritis - p. 1679 33. 191. Emerging treatments for osteoarthritis - p. 1684 34. Section 17: Crystal-Related Arthropathies - p. 1689 35. 192. Epidemiology and classification of gout - p. 1693 36. 193. Etiology and pathogenesis of gout - p. 1700 37. 194. Clinical features of gout - p. 1713 38. 195. Management of gout and hyperuricemia - p. 1716 39. 196. Calcium pyrophosphate deposition disease (pseudogout) - p. 1724 40. 197. Basic calcium phosphate crystal deposition disease - p. 1735 41. Section 18: Metabolic Bone Disease - p. 1741 42. 198. Epidemiology and classification of osteoporosis - p. 1743 43. 199. Clinical evaluation and clinical features of osteoporosis - p. 1752 44. 200. Pathophysiology of osteoporosis - p. 1760 45. 201. Biochemical markers of bone turnover in postmenopausal osteoporosis - p. 1765 46. 202. Management of osteoporosis - p. 1774 47. 203. Glucocorticoid-induced osteoporosis - p. 1788 48. 204. Osteomalacia, rickets, and renal osteodystrophy - p. 1796 49. 205. Paget disease of bone - p. 1803 50. Section 19: Other Arthropathies and Miscellaneous Disorders - p. 1810 51. 206. Diffuse idiopathic skeletal hyperostosis - p. 1811 52. 207. Neuropathic arthropathy - p. 1818 53. 208. Osteonecrosis - p. 1824 54. 209. Rheumatoid manifestations of endocrine and metabolic diseases and treatments - p. 1833 55. 210. Hemophilia-associated arthritis - p. 1840 56. 211. Rheumatologic manifestations of hemoglobinopathies - p. 1848 57. 212. Hemochromatosis - p. 1853 58. 213. Gaucher disease - p. 1857 59. 214. Digital clubbing and hypertrophic osteoarthropathy - p. 1863 60. 215. Miscellaneous arthropathies - p. 1868 61. 216. Heritable connective tissue disorders - p. 1882 62. 217. Hypermobility syndrome - p. 1902 63. 218. Bone tumors - p. 1907.e1 64. Appendix:. Classification and Diagnostic Criteria - p. 1907.e17 65. Acute Rheumatic Fever - p. 1907.e19 66. Adult-Onset Still Disease - p. 1907.e20 67. Antiphospholipid Syndrome - p. 1907.e21 68. Complex Regional Pain Syndrome - p. 1907.e22 69. Diffuse Idiopathic Skeletal Hyperostosis - p. 1907.e23 70. Fibromyalgia - p. 1907.e23 71. Gout - p. 1907.e25 72. Hypermobility - p. 1907.e26 73. Igg4-Related Disease - p. 1907.e28 74. Inflammatory Muscle Disease - p. 1907.e29 75. Juvenile Idiopathic Arthritis - p. 1907.e34 76. Kashin-Beck Disease - p. 1907.e35 77. Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis - p. 1907.e35 78. Osteoarthritis - p. 1907.e36 79. Psoriatic Arthritis - p. 1907.e37 80. Reactive Arthritis - p. 1907.e38 81. Relapsing Polychondritis - p. 1907.e38 82. Rheumatoid Arthritis - p. 1907.e39 83. Sjögren Syndrome - p. 1907.e39 84. Spondyloarthritis - p. 1907.e40 85. Systemic Lupus Erythematosus - p. 1907.e43 86. Systemic Sclerosis And Scleroderma - p. 1907.e48 87. Vasculitis - p. 1907.e49 88. Index - p. 1907.e65 89. Rheumatic Disease Clinics - p. 1907.e65
