The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases.
Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings.
1. 1 Introduction - p. G18 2. 2.1 Synaptic Structure - p. G22 3. 2.2 The Synaptic Vesicle Cycle - p. G32 4. 2.3 A Glimpse into the Nanometric Molecular Organization of the Synapse - p. G59 5. 2.4 Synchronous, A-synchronous and Spontaneous Release: Physiological and Molecular Perspectives - p. G62 6. 2.5 Molecular Aspects of Synaptic Plasticity - p. G69 7. 2.6 Genetic Manipulations of Synaptic Proteins and Behavioral Consequences - p. G79 8. 3 Conclusions - p. G82 9. References - p. G82 10. Chapter Three. The First Hour in the Life of a Synapse: Contact Formation, Partner Selection, and Onset of Function - p. G82 11. Chapter Four. Structural and Functional Organization of the Postsynaptic Density - p. G123 12. Chapter Five. The Tripartite Synapse: A Role for Glial Cells in Modulating Synaptic Transmission - p. G143 13. Chapter Six. Local Protein Synthesis at Synapses - p. G168 14. Chapter Seven. Estrogen Effects on Hippocampal Synapses - p. G191 15. Chapter Eight. Trafficking of Glutamate Receptors and Associated Proteins in Synaptic Plasticity - p. G214 16. Chapter Nine. Structural Alterations of Synapses in Psychiatric and Neurodegenerative Disorders - p. G261 17. Chapter Ten. Synaptic Correlates of Aging and Cognitive Decline - p. G294 18. Chapter Eleven. Activity-Induced Fine Structural Changes of Synapses in Mammalian Central Nervous System - p. G334 19. Chapter Twelve. Activity-Mediated Structural Plasticity of Dendritic Spines - p. G373 20. Chapter Thirteen. Experience-Dependent Synaptic Plasticity in the Developing Cerebral Cortex - p. G390 21. Chapter Fourteen. Asynaptic and Synaptic Innervation by Acetylcholine Neurons of the Central Nervous System - p. G436 22. Chapter Fifteen. Prefrontal Cortical Dopamine Transmission: Ultrastructural Studies and Their Functional Implications - p. G460 23. Index - p. G490
The Synapse summarizes recent advances in cellular and molecular mechanisms of synaptic transmission and provides new insights into neuronal plasticity and the cellular basis of neurological diseases.
Each chapter is illustrated with drawings and images derived from calcium imaging, electron microscopic immunolabeling, or electrophysiology. This book is a valuable reference for neuroscientists and clinical neurologists in both research and clinical settings.
1. 1 Introduction - p. G18 2. 2.1 Synaptic Structure - p. G22 3. 2.2 The Synaptic Vesicle Cycle - p. G32 4. 2.3 A Glimpse into the Nanometric Molecular Organization of the Synapse - p. G59 5. 2.4 Synchronous, A-synchronous and Spontaneous Release: Physiological and Molecular Perspectives - p. G62 6. 2.5 Molecular Aspects of Synaptic Plasticity - p. G69 7. 2.6 Genetic Manipulations of Synaptic Proteins and Behavioral Consequences - p. G79 8. 3 Conclusions - p. G82 9. References - p. G82 10. Chapter Three. The First Hour in the Life of a Synapse: Contact Formation, Partner Selection, and Onset of Function - p. G82 11. Chapter Four. Structural and Functional Organization of the Postsynaptic Density - p. G123 12. Chapter Five. The Tripartite Synapse: A Role for Glial Cells in Modulating Synaptic Transmission - p. G143 13. Chapter Six. Local Protein Synthesis at Synapses - p. G168 14. Chapter Seven. Estrogen Effects on Hippocampal Synapses - p. G191 15. Chapter Eight. Trafficking of Glutamate Receptors and Associated Proteins in Synaptic Plasticity - p. G214 16. Chapter Nine. Structural Alterations of Synapses in Psychiatric and Neurodegenerative Disorders - p. G261 17. Chapter Ten. Synaptic Correlates of Aging and Cognitive Decline - p. G294 18. Chapter Eleven. Activity-Induced Fine Structural Changes of Synapses in Mammalian Central Nervous System - p. G334 19. Chapter Twelve. Activity-Mediated Structural Plasticity of Dendritic Spines - p. G373 20. Chapter Thirteen. Experience-Dependent Synaptic Plasticity in the Developing Cerebral Cortex - p. G390 21. Chapter Fourteen. Asynaptic and Synaptic Innervation by Acetylcholine Neurons of the Central Nervous System - p. G436 22. Chapter Fifteen. Prefrontal Cortical Dopamine Transmission: Ultrastructural Studies and Their Functional Implications - p. G460 23. Index - p. G490
