The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics research. This serial continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.
1. I. Introduction 2. II. Structural, Functional, and Molecular Characteristics of Tumor Vasculature 3. III. Basis of Contrast in MR Images 4. IV. Imaging Receptor Expression 5. V. Imaging Vascular Targeting 6. VI. Multimodal Molecular-Functional Imaging of Tumor Vasculature 7. VII. Conclusion 8. Acknowledgments 9. An Integrated Approach for the Rational Design of Nanovectors for Biomedical Imaging and Therapy 10. I. Introduction 11. II. Three Generations of Nanovectors 12. III. Mathematical Models for Predicting the Nanovectors' Behavior 13. IV. Biophysical Characterization of Nanovectors 14. V. Vascular Targeting Moieties 15. VI. In vitro Assays for Nanovectors' Characterization 16. VII. Intravital Video Microscopy 17. VIII. Conclusions 18. Acknowledgments 19. Targeted Systemic Gene Therapy and Molecular Imaging of Cancer 20. I. Introduction 21. II. Targeted Gene Delivery 22. III. Conclusions and Perspectives 23. Cationic and Tissue-Specific Protein Transduction Domains 24. I. Introduction 25. II. Cationic Protein Transduction Domains 26. III. Biopanning using Peptide Phage Display Libraries 27. IV. Peptide Phage Display Biopanning in Cell Culture for Transduction Peptides 28. V. Methods for Analysis of Transduction Efficiency 29. VI. Peptide Phage Display Biopanning in vivo for Transduction Peptides 30. VII. PTDs as Therapeutics 31. VIII. Conclusions 32. GRP78 Signaling Hub 33. Abbreviations 34. I. Introduction 35. II. GRP78 Association with Activated α2-Macroglobulin Promotes Cell Proliferation 36. III. GRP78 Autoantibody Predicts Poor Prognosis in Tumors but Shows Therapeutic Effects in Rheumatoid Arthritis 37. IV. GRP78 Promotes Endothelial Cell Survival in Association with T-Cadherin 38. V. Cripto Mitogenic Signaling is GRP78-Dependent 39. VI. Interaction of GRP78 with Plasminogen Kringle 5 and Microplasminogen Leads to Apoptosis or the UPR 40. VII. GRP78 Association with Extracellular Par-4 Activates the Extrinsic Apoptotic Pathway 41. VIII. GRP78 Inhibits Tissue Factor-Mediated Procoagulant Activity 42. IX. GRP78 Targeting Peptides Inhibit Tumor Growth 43. X. Conclusions 44. On the Synergistic Effects of Ligand-Mediated and Phage-Intrinsic Properties During In Vivo Selection 45. I. Introduction 46. II. Ligand–Receptor Mediated Effects 47. III. Synergistic Effects Intrinsic to Phage 48. IV. Conclusion 49. Strategies for Targeting Tumors and Tumor Vasculature for Cancer Therapy 50. I. Introduction 51. II. Isolated Limb Perfusion 52. III. Isolated Liver Perfusion 53. IV. Chemoembolization 54. V. Gene Therapy Strategies Available to Target the Tumor and the Tumor-Associated Vasculature 55. VI. Conclusions
The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in knowledge gained from genetics research. This serial continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.
1. I. Introduction 2. II. Structural, Functional, and Molecular Characteristics of Tumor Vasculature 3. III. Basis of Contrast in MR Images 4. IV. Imaging Receptor Expression 5. V. Imaging Vascular Targeting 6. VI. Multimodal Molecular-Functional Imaging of Tumor Vasculature 7. VII. Conclusion 8. Acknowledgments 9. An Integrated Approach for the Rational Design of Nanovectors for Biomedical Imaging and Therapy 10. I. Introduction 11. II. Three Generations of Nanovectors 12. III. Mathematical Models for Predicting the Nanovectors' Behavior 13. IV. Biophysical Characterization of Nanovectors 14. V. Vascular Targeting Moieties 15. VI. In vitro Assays for Nanovectors' Characterization 16. VII. Intravital Video Microscopy 17. VIII. Conclusions 18. Acknowledgments 19. Targeted Systemic Gene Therapy and Molecular Imaging of Cancer 20. I. Introduction 21. II. Targeted Gene Delivery 22. III. Conclusions and Perspectives 23. Cationic and Tissue-Specific Protein Transduction Domains 24. I. Introduction 25. II. Cationic Protein Transduction Domains 26. III. Biopanning using Peptide Phage Display Libraries 27. IV. Peptide Phage Display Biopanning in Cell Culture for Transduction Peptides 28. V. Methods for Analysis of Transduction Efficiency 29. VI. Peptide Phage Display Biopanning in vivo for Transduction Peptides 30. VII. PTDs as Therapeutics 31. VIII. Conclusions 32. GRP78 Signaling Hub 33. Abbreviations 34. I. Introduction 35. II. GRP78 Association with Activated α2-Macroglobulin Promotes Cell Proliferation 36. III. GRP78 Autoantibody Predicts Poor Prognosis in Tumors but Shows Therapeutic Effects in Rheumatoid Arthritis 37. IV. GRP78 Promotes Endothelial Cell Survival in Association with T-Cadherin 38. V. Cripto Mitogenic Signaling is GRP78-Dependent 39. VI. Interaction of GRP78 with Plasminogen Kringle 5 and Microplasminogen Leads to Apoptosis or the UPR 40. VII. GRP78 Association with Extracellular Par-4 Activates the Extrinsic Apoptotic Pathway 41. VIII. GRP78 Inhibits Tissue Factor-Mediated Procoagulant Activity 42. IX. GRP78 Targeting Peptides Inhibit Tumor Growth 43. X. Conclusions 44. On the Synergistic Effects of Ligand-Mediated and Phage-Intrinsic Properties During In Vivo Selection 45. I. Introduction 46. II. Ligand–Receptor Mediated Effects 47. III. Synergistic Effects Intrinsic to Phage 48. IV. Conclusion 49. Strategies for Targeting Tumors and Tumor Vasculature for Cancer Therapy 50. I. Introduction 51. II. Isolated Limb Perfusion 52. III. Isolated Liver Perfusion 53. IV. Chemoembolization 54. V. Gene Therapy Strategies Available to Target the Tumor and the Tumor-Associated Vasculature 55. VI. Conclusions
