Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.
1. 1. Introduction - p. 317 2. 2. Genome structure of SARS-CoV and its replications - p. 318 3. 3. Structure and functions of Coronavirus main proteases - p. 319 4. 4. Catalytic site of SARS-CoV Mpro - p. 321 5. 5. Substrate binding sites of SARS-CoV Mpro - p. 321 6. 6. RNA interference and vaccines of SARS-CoV - p. 322 7. 7. Development of QSAR models - p. 323 8. 8. Overview and conclusions - p. 402 9. Chapter 12: Herpesvirus Proteases: Structure, Function, and Inhibition - p. 409 10. Chapter 13: Design and Development of Inhibitors of Herpes Viral Proteases and Their SAR and QSAR - p. 439 11. Chapter 14: Delicate Dance in Treating Hepatitis C Infections and Overcoming Resistance - p. 467 12. Index - p. 488
Viral Proteases and Their Inhibitors provides a thorough examination of viral proteases from their molecular components, to therapeutic applications. As information on three dimensional structures and biological functions of these viral proteases become known, unexpected protein folds and unique mechanisms of proteolysis are realized. This book investigates how this facilitates the design and development of potent antiviral agents used against life-threatening viruses. Users will find descriptions of each virus that detail the structure and function of viral proteases, discuss the design and development of inhibitors, and analyze the structure-activity relationships of inhibitors. This book is ideal biochemists, virologists and those working on antiviral agents.
1. 1. Introduction - p. 317 2. 2. Genome structure of SARS-CoV and its replications - p. 318 3. 3. Structure and functions of Coronavirus main proteases - p. 319 4. 4. Catalytic site of SARS-CoV Mpro - p. 321 5. 5. Substrate binding sites of SARS-CoV Mpro - p. 321 6. 6. RNA interference and vaccines of SARS-CoV - p. 322 7. 7. Development of QSAR models - p. 323 8. 8. Overview and conclusions - p. 402 9. Chapter 12: Herpesvirus Proteases: Structure, Function, and Inhibition - p. 409 10. Chapter 13: Design and Development of Inhibitors of Herpes Viral Proteases and Their SAR and QSAR - p. 439 11. Chapter 14: Delicate Dance in Treating Hepatitis C Infections and Overcoming Resistance - p. 467 12. Index - p. 488
