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Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.

1. INTRODUCTION - p. 61 2. COMMONLY USED METHODOLOGIES IN MOLECULAR DIAGNOSTICS - p. 61 3. APPLICATIONS OF MOLECULAR GENETIC TESTING IN HEMATOLOGIC MALIGNANCIES - p. 61 4. APPLICATIONS OF MOLECULAR GENETIC TESTING IN NONMALIGNANT HEMATOLOGIC DISORDERS - p. 66 5. FUTURE DIRECTIONS - p. 67 6. Chapter 4: Review Questions - p. 68 7. Part 2 THE NORMAL HEMATOLOGIC SYSTEM - p. 68 8. Chapter 5 Origin and Development of Blood Cells - p. 69 9. Chapter 6 The Birth, Life, and Death of Red Blood Cells: Erythropoiesis, the Mature Red Blood Cell, and Cell Destruction - p. 93 10. Chapter 7 Neutrophilic Leukocytes - p. 136 11. Chapter 8 The Human Eosinophil - p. 168 12. Chapter 9 Mast Cells and Basophils: Ontogeny, Characteristics, and Functional Diversity - p. 196 13. INTRODUCTION - p. 196 14. GENERAL MORPHOLOGY, MEDIATOR SECRETION, AND RECOVERY - p. 196 15. ONTOGENY AND DEVELOPMENTAL BIOLOGY OF MAST CELLS AND BASOPHILS - p. 197 16. CHARACTERISTICS OF MAST CELLS AND BASOPHILS - p. 200 17. BASOPHIL AND MAST CELL FUNCTIONS - p. 203 18. Chapter 9: Review Questions - p. 207 19. Chapter 10 Monocytes, Macrophages, and Dendritic Cells - p. 208 20. Chapter 11 Lymphocytes and Lymphatic Organs - p. 233 21. Chapter 12 B Lymphocytes - p. 267 22. Chapter 13 T Lymphocytes - p. 288 23. Chapter 14 Natural Killer and Innate Lymphoid Cells - p. 309 24. Chapter 15 Major Histocompatibility Complex - p. 322 25. Chapter 16 Complement System - p. 338 26. Chapter 17 Megakaryocytes - p. 356 27. Chapter 18 Platelet Structure - p. 391 28. Chapter 19 Platelet Function in Hemostasis and Thrombosis - p. 402 29. Chapter 20 Blood Coagulation and Fibrinolysis - p. 427 30. Chapter 21 Endothelium: Angiogenesis and the Regulation of Hemostasis - p. 531 31. Part 3 TRANSFUSION MEDICINE - p. 539 32. Chapter 22 Red Cell, Platelet, and White Cell Antigens - p. 540 33. Chapter 23 Transfusion Medicine - p. 558 34. Part 4 DISORDERS OF RED BLOOD CELLS - p. 599 35. Chapter 24 Anemia: General Considerations - p. 600 36. Chapter 25 Iron Deficiency and Related Disorders - p. 627 37. Chapter 26 Sideroblastic Anemias - p. 656 38. Chapter 27 Hemochromatosis - p. 678 39. Chapter 28 Porphyrias - p. 702 40. Chapter 29 Hereditary Spherocytosis, Hereditary Elliptocytosis, and Other Disorders Associated With Abnormalities of the Erythrocyte Membrane - p. 726 41. Chapter 30 Hereditary Hemolytic Anemias Due to Red Blood Cell Enzyme Disorders - p. 749 42. Chapter 31 Autoimmune Hemolytic Anemia - p. 770 43. Chapter 32 Paroxysmal Nocturnal Hemoglobinuria - p. 792 44. Chapter 33 Acquired Nonimmune Hemolytic Disorders - p. 821 45. Chapter 34 Sickle Cell Anemia and Other Sickling Syndromes - p. 833 46. Chapter 35 Thalassemia Syndromes: Quantitative Disorders of Globin Chain Synthesis - p. 883 47. Chapter 36 Hemoglobins With Altered Oxygen Affinity, Unstable Hemoglobins, M-Hemoglobins, and Dyshemoglobinemias - p. 933 48. Chapter 37 Megaloblastic Anemias: Disorders of Impaired DNA Synthesis - p. 945 49. Chapter 38 Inherited Aplastic Anemia Syndromes Germline - p. 974 50. Chapter 39 Acquired Aplastic Anemia - p. 995 51. Chapter 40 Red Cell Aplasia: Acquired and Congenital Disorders - p. 1008 52. Chapter 41 Congenital Dyserythropoietic Anemias - p. 1020 53. Chapter 42 Anemia of Inflammation and of Systemic Disorders - p. 1033 54. Chapter 43 Anemias During Pregnancy and the Postpartum Period - p. 1047 55. Chapter 44 Anemias Unique to the Fetus and Neonate - p. 1053 56. Chapter 45 Erythrocytosis - p. 1070 57. Part 5 DISORDERS OF HEMOSTASIS AND COAGULATION - p. 1079 58. Chapter 46 Diagnostic Approach to the Bleeding Disorders - p. 1079 59. Chapter 47 Thrombocytopenia: Pathophysiology and Classification - p. 1094 60. Chapter 48 Thrombocytopenia Caused by Immunologic Platelet Destruction - p. 1097 61. Chapter 49 Thrombotic Thrombocytopenic Purpura, Hemolytic-Uremic Syndrome, and Related Disorders - p. 1123 62. Chapter 50 Miscellaneous Causes of Thrombocytopenia - p. 1153 63. Chapter 51 Bleeding Disorders Caused by Vascular Abnormalities - p. 1162 64. Chapter 52 Thrombocytosis and Essential Thrombocythemia - p. 1175 65. Chapter 53 Qualitative Disorders of Platelet Function - p. 1182 66. Chapter 54 Inherited Coagulation Disorders - p. 1201 67. Chapter 55 Acquired Coagulation Disorders - p. 1241 68. Chapter 56 Thrombosis and Antithrombotic Therapy - p. 1275 69. Part 6 DISORDERS OF LEUKOCYTES, IMMUNODEFICIENCY, AND THE SPLEEN - p. 1320 70. Chapter 57 Diagnostic Approach to Tissue Examination and Testing - p. 1321 71. Chapter 58 Neutropenia - p. 1331 72. Chapter 59 Qualitative Disorders of Leukocytes - p. 1344 73. Chapter 60 Lysosomal Abnormalities of the Monocyte-Macrophage System: Gaucher and Niemann-Pick Diseases - p. 1359 74. Chapter 61 Langerhans Cell Histiocytosis - p. 1364 75. Chapter 62 Pathology of Langerhans Cell Histiocytosis and Other Histiocytic Proliferations - p. 1376 76. Chapter 63 Infectious Mononucleosis and Other Epstein-Barr Virus–Related Disorders - p. 1382 77. Chapter 64 Primary Immunodeficiency Diseases - p. 1393 78. Chapter 65 Human Immunodeficiency Virus Infection - p. 1409 79. Chapter 66 Disorders of the Spleen - p. 1423 80. Chapter 67 Tumors of the Spleen - p. 1437 81. Part 7 HEMATOLOGIC MALIGNANCIES - p. 1443 82. Chapter 68 Hematopoietic Neoplasms: Principles of Pathologic Diagnosis - p. 1444 83. Chapter 69 Principles of Targeted Therapies for Hematologic Malignancies - p. 1454 84. Chapter 70 Infectious Complications in Hematologic Malignancies - p. 1468 85. Chapter 71 Immunotherapy - p. 1494 86. Chapter 72 Gene Therapy for Hematopoietic Stem Cell Disorders - p. 1522 87. Chapter 73 Molecular Genetics of Acute Leukemia - p. 1562 88. Chapter 74 Diagnosis and Classification of the Acute Leukemias and Myelodysplastic Syndromes - p. 1595 89. Chapter 75 Acute Lymphoblastic Leukemia in Adults - p. 1608 90. Chapter 76 Acute Myeloid Leukemia in Adults - p. 1627 91. Chapter 77 Acute Lymphoblastic Leukemia in Children - p. 1667 92. Chapter 78 Acute Myeloid Leukemia in Children - p. 1694 93. Chapter 79 Acute Promyelocytic Leukemia - p. 1721 94. Chapter 80 Myelodysplastic Syndromes - p. 1737 95. Chapter 81 Clonal Hematopoiesis of Indeterminate Potential and Myeloid Diseases - p. 1754 96. Chapter 82 Pathology of the Myeloproliferative Neoplasms - p. 1763 97. Chapter 83 Chronic Myeloid Leukemia - p. 1782 98. Chapter 84 Polycythemia Vera - p. 1808 99. Chapter 85 Myelofibrosis - p. 1821 100. Chapter 86 Eosinophilic Neoplasms and Hypereosinophilic Syndrome - p. 1836 101. Chapter 87 Systemic Mastocytosis - p. 1849 102. Chapter 88 Diagnosis and Classification of Lymphomas - p. 1866 103. Chapter 89 Molecular Genetic Aspects of Non-Hodgkin Lymphomas - p. 1900 104. Chapter 90 Non-Hodgkin Lymphoma in Adults - p. 1942 105. Chapter 91 Non-Hodgkin Lymphoma in Children - p. 1991 106. Chapter 92 Chronic Lymphocytic Leukemia - p. 2010 107. Chapter 93 Hairy Cell Leukemia - p. 2049 108. Chapter 94 Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome - p. 2072 109. Chapter 95 Hodgkin Lymphoma in Adults - p. 2116 110. Chapter 96 Hodgkin Lymphoma in Children - p. 2133 111. Chapter 97 Practical Approach to the Evaluation of Monoclonal Gammopathies - p. 2143 112. INTRODUCTION - p. 2144 113. CLASSIFICATION OF MONOCLONAL IMMUNOGLOBULIN DISORDERS - p. 2144 114. DIAGNOSTIC ALGORITHM - p. 2144 115. DIFFERENTIAL DIAGNOSIS OF MONOCLONAL GAMMOPATHY - p. 2144 116. INITIAL EVALUATION - p. 2146 117. LABORATORY EVALUATION - p. 2146 118. IMAGING - p. 2148 119. HISTORY AND PHYSICAL EVALUATION - p. 2150 120. SUMMARY AND RECOMMENDATIONS - p. 2150 121. Chapter 97: Review Questions - p. 2151 122. Chapter 98 Molecular Genetic Aspects of Plasma Cell Disorders - p. 2152 123. INTRODUCTION - p. 2152 124. PLASMA CELL DEVELOPMENT - p. 2152 125. MULTIPLE MYELOMA IS A PLASMA CELL TUMOR OF POSTGERMINAL CENTER B CELLS - p. 2152 126. EARLY GENETIC ABNORMALITIES IN MULTIPLE MYELOMA - p. 2153 127. SECONDARY ONCOGENIC EVENTS ASSOCIATED WITH PROGRESSION OF MGUS TO MULTIPLE MYELOMA - p. 2153 128. HIGH-RESOLUTION SEQUENCING STUDIES AND ADDITIONAL COMPLEXITY OF MM GENOMES - p. 2155 129. BEYOND DNA: LESSONS FROM RNA EXPRESSION STUDIES - p. 2157 130. CONCLUSION - p. 2157 131. Chapter 98: Review Questions - p. 2159 132. Chapter 99 Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma - p. 2160 133. Chapter 100 Multiple Myeloma - p. 2175 134. Chapter 101 Immunoglobulin Light Chain Amyloidosis - p. 2238 135. Chapter 102 Waldenström Macroglobulinemia - p. 2267 136. Chapter 103 Monoclonal Gammopathies of Clinical Significance - p. 2276 137. INTRODUCTION - p. 2276 138. MONOCLONAL GAMMOPATHIES OF NEUROLOGICAL SIGNIFICANCE - p. 2276 139. MONOCLONAL GAMMOPATHIES OF DERMATOLOGIC SIGNIFICANCE - p. 2281 140. MONOCLONAL GAMMOPATHIES OF RENAL SIGNIFICANCE - p. 2289 141. OTHER MONOCLONAL GAMMOPATHIES OF CLINICAL SIGNIFICANCE - p. 2291 142. Chapter 103: Review Questions - p. 2296 143. Part 8 HEMATOPOIETIC CELLULAR THERAPY - p. 2296 144. Chapter 104 Hematopoietic Cell Transplantation - p. 2297 145. Chapter 105 Hematopoietic Cell Transplantation for Nonmalignant Disorders - p. 2314 146. Chapter 106 Hematopoietic Cell Transplantation for Hematologic Malignancies - p. 2335 147. Chapter 107 Graft-vs-Host Disease and Graft-vs-Tumor Response - p. 2355 148. Chapter 108 Late Effects After Hematopoietic Cell Transplantation - p. 2371 149. Index - p. I-1

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Comprehensive in scope and thoroughly up to date, Wintrobe’s Clinical Hematology, 15th Edition, combines the biology and pathophysiology of hematology as well as the diagnosis and treatment of commonly encountered hematological disorders. Editor-in-chief Dr. Robert T. Means, Jr., along with a team of expert section editors and contributing authors, provide authoritative, in-depth information on the biology and pathophysiology of lymphomas, leukemias, platelet destruction, and other hematological disorders as well as the procedures for diagnosing and treating them. Packed with more than 1,500 tables and figures throughout, this trusted text is an indispensable reference for hematologists, oncologists, residents, nurse practitioners, and pathologists.

1. INTRODUCTION - p. 61 2. COMMONLY USED METHODOLOGIES IN MOLECULAR DIAGNOSTICS - p. 61 3. APPLICATIONS OF MOLECULAR GENETIC TESTING IN HEMATOLOGIC MALIGNANCIES - p. 61 4. APPLICATIONS OF MOLECULAR GENETIC TESTING IN NONMALIGNANT HEMATOLOGIC DISORDERS - p. 66 5. FUTURE DIRECTIONS - p. 67 6. Chapter 4: Review Questions - p. 68 7. Part 2 THE NORMAL HEMATOLOGIC SYSTEM - p. 68 8. Chapter 5 Origin and Development of Blood Cells - p. 69 9. Chapter 6 The Birth, Life, and Death of Red Blood Cells: Erythropoiesis, the Mature Red Blood Cell, and Cell Destruction - p. 93 10. Chapter 7 Neutrophilic Leukocytes - p. 136 11. Chapter 8 The Human Eosinophil - p. 168 12. Chapter 9 Mast Cells and Basophils: Ontogeny, Characteristics, and Functional Diversity - p. 196 13. INTRODUCTION - p. 196 14. GENERAL MORPHOLOGY, MEDIATOR SECRETION, AND RECOVERY - p. 196 15. ONTOGENY AND DEVELOPMENTAL BIOLOGY OF MAST CELLS AND BASOPHILS - p. 197 16. CHARACTERISTICS OF MAST CELLS AND BASOPHILS - p. 200 17. BASOPHIL AND MAST CELL FUNCTIONS - p. 203 18. Chapter 9: Review Questions - p. 207 19. Chapter 10 Monocytes, Macrophages, and Dendritic Cells - p. 208 20. Chapter 11 Lymphocytes and Lymphatic Organs - p. 233 21. Chapter 12 B Lymphocytes - p. 267 22. Chapter 13 T Lymphocytes - p. 288 23. Chapter 14 Natural Killer and Innate Lymphoid Cells - p. 309 24. Chapter 15 Major Histocompatibility Complex - p. 322 25. Chapter 16 Complement System - p. 338 26. Chapter 17 Megakaryocytes - p. 356 27. Chapter 18 Platelet Structure - p. 391 28. Chapter 19 Platelet Function in Hemostasis and Thrombosis - p. 402 29. Chapter 20 Blood Coagulation and Fibrinolysis - p. 427 30. Chapter 21 Endothelium: Angiogenesis and the Regulation of Hemostasis - p. 531 31. Part 3 TRANSFUSION MEDICINE - p. 539 32. Chapter 22 Red Cell, Platelet, and White Cell Antigens - p. 540 33. Chapter 23 Transfusion Medicine - p. 558 34. Part 4 DISORDERS OF RED BLOOD CELLS - p. 599 35. Chapter 24 Anemia: General Considerations - p. 600 36. Chapter 25 Iron Deficiency and Related Disorders - p. 627 37. Chapter 26 Sideroblastic Anemias - p. 656 38. Chapter 27 Hemochromatosis - p. 678 39. Chapter 28 Porphyrias - p. 702 40. Chapter 29 Hereditary Spherocytosis, Hereditary Elliptocytosis, and Other Disorders Associated With Abnormalities of the Erythrocyte Membrane - p. 726 41. Chapter 30 Hereditary Hemolytic Anemias Due to Red Blood Cell Enzyme Disorders - p. 749 42. Chapter 31 Autoimmune Hemolytic Anemia - p. 770 43. Chapter 32 Paroxysmal Nocturnal Hemoglobinuria - p. 792 44. Chapter 33 Acquired Nonimmune Hemolytic Disorders - p. 821 45. Chapter 34 Sickle Cell Anemia and Other Sickling Syndromes - p. 833 46. Chapter 35 Thalassemia Syndromes: Quantitative Disorders of Globin Chain Synthesis - p. 883 47. Chapter 36 Hemoglobins With Altered Oxygen Affinity, Unstable Hemoglobins, M-Hemoglobins, and Dyshemoglobinemias - p. 933 48. Chapter 37 Megaloblastic Anemias: Disorders of Impaired DNA Synthesis - p. 945 49. Chapter 38 Inherited Aplastic Anemia Syndromes Germline - p. 974 50. Chapter 39 Acquired Aplastic Anemia - p. 995 51. Chapter 40 Red Cell Aplasia: Acquired and Congenital Disorders - p. 1008 52. Chapter 41 Congenital Dyserythropoietic Anemias - p. 1020 53. Chapter 42 Anemia of Inflammation and of Systemic Disorders - p. 1033 54. Chapter 43 Anemias During Pregnancy and the Postpartum Period - p. 1047 55. Chapter 44 Anemias Unique to the Fetus and Neonate - p. 1053 56. Chapter 45 Erythrocytosis - p. 1070 57. Part 5 DISORDERS OF HEMOSTASIS AND COAGULATION - p. 1079 58. Chapter 46 Diagnostic Approach to the Bleeding Disorders - p. 1079 59. Chapter 47 Thrombocytopenia: Pathophysiology and Classification - p. 1094 60. Chapter 48 Thrombocytopenia Caused by Immunologic Platelet Destruction - p. 1097 61. Chapter 49 Thrombotic Thrombocytopenic Purpura, Hemolytic-Uremic Syndrome, and Related Disorders - p. 1123 62. Chapter 50 Miscellaneous Causes of Thrombocytopenia - p. 1153 63. Chapter 51 Bleeding Disorders Caused by Vascular Abnormalities - p. 1162 64. Chapter 52 Thrombocytosis and Essential Thrombocythemia - p. 1175 65. Chapter 53 Qualitative Disorders of Platelet Function - p. 1182 66. Chapter 54 Inherited Coagulation Disorders - p. 1201 67. Chapter 55 Acquired Coagulation Disorders - p. 1241 68. Chapter 56 Thrombosis and Antithrombotic Therapy - p. 1275 69. Part 6 DISORDERS OF LEUKOCYTES, IMMUNODEFICIENCY, AND THE SPLEEN - p. 1320 70. Chapter 57 Diagnostic Approach to Tissue Examination and Testing - p. 1321 71. Chapter 58 Neutropenia - p. 1331 72. Chapter 59 Qualitative Disorders of Leukocytes - p. 1344 73. Chapter 60 Lysosomal Abnormalities of the Monocyte-Macrophage System: Gaucher and Niemann-Pick Diseases - p. 1359 74. Chapter 61 Langerhans Cell Histiocytosis - p. 1364 75. Chapter 62 Pathology of Langerhans Cell Histiocytosis and Other Histiocytic Proliferations - p. 1376 76. Chapter 63 Infectious Mononucleosis and Other Epstein-Barr Virus–Related Disorders - p. 1382 77. Chapter 64 Primary Immunodeficiency Diseases - p. 1393 78. Chapter 65 Human Immunodeficiency Virus Infection - p. 1409 79. Chapter 66 Disorders of the Spleen - p. 1423 80. Chapter 67 Tumors of the Spleen - p. 1437 81. Part 7 HEMATOLOGIC MALIGNANCIES - p. 1443 82. Chapter 68 Hematopoietic Neoplasms: Principles of Pathologic Diagnosis - p. 1444 83. Chapter 69 Principles of Targeted Therapies for Hematologic Malignancies - p. 1454 84. Chapter 70 Infectious Complications in Hematologic Malignancies - p. 1468 85. Chapter 71 Immunotherapy - p. 1494 86. Chapter 72 Gene Therapy for Hematopoietic Stem Cell Disorders - p. 1522 87. Chapter 73 Molecular Genetics of Acute Leukemia - p. 1562 88. Chapter 74 Diagnosis and Classification of the Acute Leukemias and Myelodysplastic Syndromes - p. 1595 89. Chapter 75 Acute Lymphoblastic Leukemia in Adults - p. 1608 90. Chapter 76 Acute Myeloid Leukemia in Adults - p. 1627 91. Chapter 77 Acute Lymphoblastic Leukemia in Children - p. 1667 92. Chapter 78 Acute Myeloid Leukemia in Children - p. 1694 93. Chapter 79 Acute Promyelocytic Leukemia - p. 1721 94. Chapter 80 Myelodysplastic Syndromes - p. 1737 95. Chapter 81 Clonal Hematopoiesis of Indeterminate Potential and Myeloid Diseases - p. 1754 96. Chapter 82 Pathology of the Myeloproliferative Neoplasms - p. 1763 97. Chapter 83 Chronic Myeloid Leukemia - p. 1782 98. Chapter 84 Polycythemia Vera - p. 1808 99. Chapter 85 Myelofibrosis - p. 1821 100. Chapter 86 Eosinophilic Neoplasms and Hypereosinophilic Syndrome - p. 1836 101. Chapter 87 Systemic Mastocytosis - p. 1849 102. Chapter 88 Diagnosis and Classification of Lymphomas - p. 1866 103. Chapter 89 Molecular Genetic Aspects of Non-Hodgkin Lymphomas - p. 1900 104. Chapter 90 Non-Hodgkin Lymphoma in Adults - p. 1942 105. Chapter 91 Non-Hodgkin Lymphoma in Children - p. 1991 106. Chapter 92 Chronic Lymphocytic Leukemia - p. 2010 107. Chapter 93 Hairy Cell Leukemia - p. 2049 108. Chapter 94 Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome - p. 2072 109. Chapter 95 Hodgkin Lymphoma in Adults - p. 2116 110. Chapter 96 Hodgkin Lymphoma in Children - p. 2133 111. Chapter 97 Practical Approach to the Evaluation of Monoclonal Gammopathies - p. 2143 112. INTRODUCTION - p. 2144 113. CLASSIFICATION OF MONOCLONAL IMMUNOGLOBULIN DISORDERS - p. 2144 114. DIAGNOSTIC ALGORITHM - p. 2144 115. DIFFERENTIAL DIAGNOSIS OF MONOCLONAL GAMMOPATHY - p. 2144 116. INITIAL EVALUATION - p. 2146 117. LABORATORY EVALUATION - p. 2146 118. IMAGING - p. 2148 119. HISTORY AND PHYSICAL EVALUATION - p. 2150 120. SUMMARY AND RECOMMENDATIONS - p. 2150 121. Chapter 97: Review Questions - p. 2151 122. Chapter 98 Molecular Genetic Aspects of Plasma Cell Disorders - p. 2152 123. INTRODUCTION - p. 2152 124. PLASMA CELL DEVELOPMENT - p. 2152 125. MULTIPLE MYELOMA IS A PLASMA CELL TUMOR OF POSTGERMINAL CENTER B CELLS - p. 2152 126. EARLY GENETIC ABNORMALITIES IN MULTIPLE MYELOMA - p. 2153 127. SECONDARY ONCOGENIC EVENTS ASSOCIATED WITH PROGRESSION OF MGUS TO MULTIPLE MYELOMA - p. 2153 128. HIGH-RESOLUTION SEQUENCING STUDIES AND ADDITIONAL COMPLEXITY OF MM GENOMES - p. 2155 129. BEYOND DNA: LESSONS FROM RNA EXPRESSION STUDIES - p. 2157 130. CONCLUSION - p. 2157 131. Chapter 98: Review Questions - p. 2159 132. Chapter 99 Monoclonal Gammopathy of Undetermined Significance and Smoldering Multiple Myeloma - p. 2160 133. Chapter 100 Multiple Myeloma - p. 2175 134. Chapter 101 Immunoglobulin Light Chain Amyloidosis - p. 2238 135. Chapter 102 Waldenström Macroglobulinemia - p. 2267 136. Chapter 103 Monoclonal Gammopathies of Clinical Significance - p. 2276 137. INTRODUCTION - p. 2276 138. MONOCLONAL GAMMOPATHIES OF NEUROLOGICAL SIGNIFICANCE - p. 2276 139. MONOCLONAL GAMMOPATHIES OF DERMATOLOGIC SIGNIFICANCE - p. 2281 140. MONOCLONAL GAMMOPATHIES OF RENAL SIGNIFICANCE - p. 2289 141. OTHER MONOCLONAL GAMMOPATHIES OF CLINICAL SIGNIFICANCE - p. 2291 142. Chapter 103: Review Questions - p. 2296 143. Part 8 HEMATOPOIETIC CELLULAR THERAPY - p. 2296 144. Chapter 104 Hematopoietic Cell Transplantation - p. 2297 145. Chapter 105 Hematopoietic Cell Transplantation for Nonmalignant Disorders - p. 2314 146. Chapter 106 Hematopoietic Cell Transplantation for Hematologic Malignancies - p. 2335 147. Chapter 107 Graft-vs-Host Disease and Graft-vs-Tumor Response - p. 2355 148. Chapter 108 Late Effects After Hematopoietic Cell Transplantation - p. 2371 149. Index - p. I-1

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