A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists.
This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries.
1. Introduction - p. G14 2. Chapter 2. A Very Special Location: The Basel Institute for Immunology - p. G18 3. Chapter 3. Immunological Specificity - p. G24 4. Chapter 4. Monoclonal Antibodies: The Final Proof for Clonal Selection - p. G30 5. Chapter 5. The First Victory of Molecular Biology: Mechanisms of the Generation of Antibody Diversity - p. G38 6. Chapter 6. The Major Histocompatibility Complex - p. G51 7. Chapter 7. Antigen Processing and Presentation - p. G93 8. Chapter 8. The Intricate Behavior of T Cells - p. G134 9. Abstract - p. G134 10. 8.1 Major Histocompatibility Complex Restriction of T-Cell Recognition - p. G134 11. 8.2 Chase for the Antigen Receptor of T Cells - p. G155 12. 8.3 T-Cell Recognition: From Facts Toward Understanding - p. G170 13. 8.4 Thymus and the T-Cell Repertoire - p. G172 14. 8.5 Alloreactivity: the Continuing Puzzle - p. G186 15. 8.6 Functional Subclasses of T cells - p. G195 16. 8.7 Cell Adhesion, Costimulation, Co-Inhibition - p. G217 17. References - p. G220 18. Chapter 9. Acquired Immunological Tolerance - p. G220 19. Chapter 10. Autoimmunity - p. G271 20. Concluding Remarks - p. G316 21. Index - p. G330
A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists.
This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries.
1. Introduction - p. G14 2. Chapter 2. A Very Special Location: The Basel Institute for Immunology - p. G18 3. Chapter 3. Immunological Specificity - p. G24 4. Chapter 4. Monoclonal Antibodies: The Final Proof for Clonal Selection - p. G30 5. Chapter 5. The First Victory of Molecular Biology: Mechanisms of the Generation of Antibody Diversity - p. G38 6. Chapter 6. The Major Histocompatibility Complex - p. G51 7. Chapter 7. Antigen Processing and Presentation - p. G93 8. Chapter 8. The Intricate Behavior of T Cells - p. G134 9. Abstract - p. G134 10. 8.1 Major Histocompatibility Complex Restriction of T-Cell Recognition - p. G134 11. 8.2 Chase for the Antigen Receptor of T Cells - p. G155 12. 8.3 T-Cell Recognition: From Facts Toward Understanding - p. G170 13. 8.4 Thymus and the T-Cell Repertoire - p. G172 14. 8.5 Alloreactivity: the Continuing Puzzle - p. G186 15. 8.6 Functional Subclasses of T cells - p. G195 16. 8.7 Cell Adhesion, Costimulation, Co-Inhibition - p. G217 17. References - p. G220 18. Chapter 9. Acquired Immunological Tolerance - p. G220 19. Chapter 10. Autoimmunity - p. G271 20. Concluding Remarks - p. G316 21. Index - p. G330
