Albinism in Africa: Historical, Geographic, Medical, Genetic, and Psychosocial Aspects provides the first in-depth reference for understanding and treating patients of human albinism in Africa. Leading international contributors examine the historical, geographic, psychosocial, genetic and molecular considerations of importance in effectively and sensitively managing this genetic disorder. Foundational chapters covering the historical and psychosocial aspects of albinism are supplemented by discussions of the pathobiology of the disease, as well as a thorough analysis of the genetics of skin pigmentation, eye pigmentation, hair pigmentation, and incidents of skin cancer involved in the manifestations of this disorder.
New prenatal diagnostics and genetic testing methods, genetic risk assessment for individuals, families, and communities, and novel genetic markers that may be used for developing new therapeutics for treating albinism are also discussed in detail. The book provides care management approaches that may be applied to instances of albinism in other regions, along with guiding principles for treating rare genetic disorders and stigmatized patient populations across the globe.
1. Chapter 1. Introduction and Historical Background - p. 1 2. Chapter 2. Clinical Features, Types of Albinism, and Natural History - p. 27 3. Chapter 3. Epidemiology of Albinism - p. 57 4. Chapter 4. Prevalence and Population Genetics of Albinism: Surveys in Zimbabwe, Namibia, and Tanzania - p. 81 5. Chapter 5. Molecular Biology of Albinism - p. 99 6. Chapter 6. Dermatological Aspects of Albinism - p. 121 7. Chapter 7. Albinism and the Eye - p. 135 8. Chapter 8. Low-Vision Rehabilitation and Albinism - p. 151 9. Chapter 9. Psychosocial and Cultural Aspects of Albinism - p. 171 10. Chapter 10. Genetic Counseling and Albinism - p. 203 11. Chapter 11. Genetic Testing, Postnatal, and Prenatal Diagnosis for Albinism - p. 235 12. Chapter 12. Albinism and Social Marginalization - p. 257 13. Chapter 13. Interventions: Preventive Management, Empowerment, Advocacy, and Support Services - p. 271 14. Chapter 14. A Personal Perspective: Living With Albinism - p. 295 15. Chapter 15. Summary and Conclusion - p. 309 16. Glossary - p. 327 17. Index - p. 335
Albinism in Africa: Historical, Geographic, Medical, Genetic, and Psychosocial Aspects provides the first in-depth reference for understanding and treating patients of human albinism in Africa. Leading international contributors examine the historical, geographic, psychosocial, genetic and molecular considerations of importance in effectively and sensitively managing this genetic disorder. Foundational chapters covering the historical and psychosocial aspects of albinism are supplemented by discussions of the pathobiology of the disease, as well as a thorough analysis of the genetics of skin pigmentation, eye pigmentation, hair pigmentation, and incidents of skin cancer involved in the manifestations of this disorder.
New prenatal diagnostics and genetic testing methods, genetic risk assessment for individuals, families, and communities, and novel genetic markers that may be used for developing new therapeutics for treating albinism are also discussed in detail. The book provides care management approaches that may be applied to instances of albinism in other regions, along with guiding principles for treating rare genetic disorders and stigmatized patient populations across the globe.
1. Chapter 1. Introduction and Historical Background - p. 1 2. Chapter 2. Clinical Features, Types of Albinism, and Natural History - p. 27 3. Chapter 3. Epidemiology of Albinism - p. 57 4. Chapter 4. Prevalence and Population Genetics of Albinism: Surveys in Zimbabwe, Namibia, and Tanzania - p. 81 5. Chapter 5. Molecular Biology of Albinism - p. 99 6. Chapter 6. Dermatological Aspects of Albinism - p. 121 7. Chapter 7. Albinism and the Eye - p. 135 8. Chapter 8. Low-Vision Rehabilitation and Albinism - p. 151 9. Chapter 9. Psychosocial and Cultural Aspects of Albinism - p. 171 10. Chapter 10. Genetic Counseling and Albinism - p. 203 11. Chapter 11. Genetic Testing, Postnatal, and Prenatal Diagnosis for Albinism - p. 235 12. Chapter 12. Albinism and Social Marginalization - p. 257 13. Chapter 13. Interventions: Preventive Management, Empowerment, Advocacy, and Support Services - p. 271 14. Chapter 14. A Personal Perspective: Living With Albinism - p. 295 15. Chapter 15. Summary and Conclusion - p. 309 16. Glossary - p. 327 17. Index - p. 335
