Alcohol abuse remains a significant problem world-wide. The most commonly affected organ remains the liver with a risk of alcoholic liver disease (ALD) which can range from asymptomatic to alcoholic hepatitis to alcoholic cirrhosis. In 2010, alcohol-attributable cirrhosis was responsible for 0.9% of all global deaths. Given the sheer magnitude of alcohol abuse and alcoholic liver disease, an update on this topic is pertinent and relevant. This issue will focus on a variety of topics including alcoholism, the pathogenesis of ALD, the spectrum of ALD, the pathology of ALD, and the long-term management of patients with ALD. Alcoholic hepatitis is a particular type of ALD with a high mortality. This issue will explore the syndrome of alcoholic hepatitis, its prognostic markers, and the available therapies. Because alcohol intake can influence so many other conditions of the liver (especially hepatitis C), articles in this issue will also explore the impact of alcohol abuse on other liver conditions. In addition, several other topics such as nutritional therapy for ALD, ALD and liver cancer, and ALD and infection risk will be explored. Also, even though it is quite controversial, we will also explore liver transplant as a therapy for alcoholic liver disease including alcoholic hepatitis.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright Page - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 6 7. Preface: Alcoholic Liver Disease - p. 7 8. Spectrum of Alcoholic Liver Disease - p. 8 9. Unhealthy Alcohol Use - p. 13 10. Pathogenesis of Alcoholic Liver Disease - p. 20 11. Diagnosis of Alcoholic Liver Disease - p. 27 12. The Pathology of Alcoholic Liver Disease - p. 36 13. Prognosis and Prognostic Scoring Models for Alcoholic Liver Disease and Acute Alcoholic Hepatitis - p. 43 14. Acute Alcoholic Hepatitis, the Clinical Aspects - p. 47 15. Acute Alcoholic Hepatitis: Therapy - p. 53 16. Alcoholic Liver Disease and Liver Transplantation - p. 60 17. Nutrition and Alcoholic Liver Disease - p. 69 18. Long-Term Management of Alcoholic Liver Disease - p. 78 19. Alcoholic Liver Disease - p. 83 20. The Effects of Alcohol on Other Chronic Liver Diseases - p. 93 21. Infection and Alcoholic Liver Disease - p. 101
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Alcohol abuse remains a significant problem world-wide. The most commonly affected organ remains the liver with a risk of alcoholic liver disease (ALD) which can range from asymptomatic to alcoholic hepatitis to alcoholic cirrhosis. In 2010, alcohol-attributable cirrhosis was responsible for 0.9% of all global deaths. Given the sheer magnitude of alcohol abuse and alcoholic liver disease, an update on this topic is pertinent and relevant. This issue will focus on a variety of topics including alcoholism, the pathogenesis of ALD, the spectrum of ALD, the pathology of ALD, and the long-term management of patients with ALD. Alcoholic hepatitis is a particular type of ALD with a high mortality. This issue will explore the syndrome of alcoholic hepatitis, its prognostic markers, and the available therapies. Because alcohol intake can influence so many other conditions of the liver (especially hepatitis C), articles in this issue will also explore the impact of alcohol abuse on other liver conditions. In addition, several other topics such as nutritional therapy for ALD, ALD and liver cancer, and ALD and infection risk will be explored. Also, even though it is quite controversial, we will also explore liver transplant as a therapy for alcoholic liver disease including alcoholic hepatitis.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright Page - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 6 7. Preface: Alcoholic Liver Disease - p. 7 8. Spectrum of Alcoholic Liver Disease - p. 8 9. Unhealthy Alcohol Use - p. 13 10. Pathogenesis of Alcoholic Liver Disease - p. 20 11. Diagnosis of Alcoholic Liver Disease - p. 27 12. The Pathology of Alcoholic Liver Disease - p. 36 13. Prognosis and Prognostic Scoring Models for Alcoholic Liver Disease and Acute Alcoholic Hepatitis - p. 43 14. Acute Alcoholic Hepatitis, the Clinical Aspects - p. 47 15. Acute Alcoholic Hepatitis: Therapy - p. 53 16. Alcoholic Liver Disease and Liver Transplantation - p. 60 17. Nutrition and Alcoholic Liver Disease - p. 69 18. Long-Term Management of Alcoholic Liver Disease - p. 78 19. Alcoholic Liver Disease - p. 83 20. The Effects of Alcohol on Other Chronic Liver Diseases - p. 93 21. Infection and Alcoholic Liver Disease - p. 101
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