"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xi 7. Chapter One: Protein intrinsic disorder and structure-function continuum - p. xii 8. Chapter Two: Intrinsic disorder associated with 14-3-3 proteins and their partners - p. 17 9. Chapter Three: Intrinsically disordered proteins and phenotypic switching: Implications in cancer - p. 61 10. Chapter Four: Translational diffusion of unfolded and intrinsically disordered proteins - p. 84 11. Chapter Five: Intrinsically disordered proteins in the formation of functional amyloids from bacteria to humans - p. 108 12. Chapter Six: Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases - p. 143 13. Chapter Seven: Shear-induced amyloid formation of IDPs in the brain - p. 223 14. Chapter Eight: Role of intrinsic disorder in muscle sarcomeres - p. 309 15. Chapter Nine: Computational prediction of functions of intrinsically disordered regions - p. 340 16. Chapter Ten: The dark proteome of cancer: Intrinsic disorderedness and functionality of HIF-1α along with its interacting proteins - p. 369 17. Index - p. 405
"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xi 7. Chapter One: Protein intrinsic disorder and structure-function continuum - p. xii 8. Chapter Two: Intrinsic disorder associated with 14-3-3 proteins and their partners - p. 17 9. Chapter Three: Intrinsically disordered proteins and phenotypic switching: Implications in cancer - p. 61 10. Chapter Four: Translational diffusion of unfolded and intrinsically disordered proteins - p. 84 11. Chapter Five: Intrinsically disordered proteins in the formation of functional amyloids from bacteria to humans - p. 108 12. Chapter Six: Intrinsically disordered proteins in various hypotheses on the pathogenesis of Alzheimer's and Parkinson's diseases - p. 143 13. Chapter Seven: Shear-induced amyloid formation of IDPs in the brain - p. 223 14. Chapter Eight: Role of intrinsic disorder in muscle sarcomeres - p. 309 15. Chapter Nine: Computational prediction of functions of intrinsically disordered regions - p. 340 16. Chapter Ten: The dark proteome of cancer: Intrinsic disorderedness and functionality of HIF-1α along with its interacting proteins - p. 369 17. Index - p. 405
