Handbook on the Toxicology of Metals, Fifth Edition, Volume I: General Considerations is the first volume of a two-volume work that gives an overview and covers topics of general importance including reviews of various health effects of trace metals. The book emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology and contains several new chapters. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health.
1. Handbook on the Toxicology of Metals - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. List of reviewers - p. Page viii 8. Preface - p. Page ix 9. List of Illustrations - p. Page x 10. List of Tables - p. Page xi 11. Chapter 1 : Toxicology of metals: Overview, definitions, concepts, and trends∗ - p. Page xi 12. Chapter 2 : General chemistry of metals, sampling, analytical methods, and speciation∗ - p. Page 13 13. Chapter 3 : Exposure, dose, and toxicokinetics of metals∗ - p. Page 49 14. Chapter 4 : Toxicity of metal and metal oxide nanoparticles - p. Page 82 15. Chapter 5 : Toxicity of metals released from implanted medical devices - p. Page 121 16. Chapter 6 : Metals and air pollution - p. Page 135 17. Chapter 7 : Toxic metals in food - p. Page 177 18. Chapter 8 : Interaction of toxic metals with the gut microbiome - p. Page 203 19. Chapter 9 : Biological monitoring of metals and biomarkers∗ - p. Page 216 20. Chapter 10 : Computational modeling and dosimetry of metals - p. Page 233 21. Chapter 11 : Selected molecular mechanisms of metal toxicity and carcinogenicity - p. Page 250 22. Chapter 12 : Effects of metals on extracellular vesicle signaling - p. Page 272 23. Chapter 13 : General considerations of dose-effect and dose-response relationships∗ - p. Page 294 24. Chapter 14 : Interactions and mixtures in metal toxicology - p. Page 317 25. Chapter 15 : Gene–environment interactions and metal toxicity - p. Page 342 26. Chapter 16 : Epidemiological approaches to metal toxicology∗ - p. Page 364 27. Chapter 17 : Essential metals: Assessing risks from deficiency and toxicity - p. Page 382 28. Chapter 18 : The interaction of metals and the skin: The good, bad, and the ugly - p. Page 405 29. Chapter 19 : Metals and the respiratory tract - p. Page 418 30. Chapter 20 : Neurotoxicology of metals - p. Page 439 31. Chapter 21 : Cardiovascular disease - p. Page 456 32. Chapter 22 : Renal effects of exposure to metals - p. Page 479 33. Chapter 23 : Carcinogenicity of metal compounds - p. Page 502 34. Chapter 24 : Immunotoxicology of metals - p. Page 536 35. Chapter 25 : Effects of metallic elements on reproduction and development - p. Page 558 36. Chapter 26 : Ecotoxicology of metals—sources, transport, and effects on the ecosystem - p. Page 587 37. Chapter 27 : Risk assessment for metal exposures - p. Page 623 38. Chapter 28 : Diagnosis and treatment of metal poisoning general aspects∗ - p. Page 659 39. Chapter 29 : Principles for prevention of the toxic effects of metals - p. Page 681 40. Chapter 30 : Metal toxicology in low-income and lower-middle-income countries∗ - p. Page 701 41. Index - p. Page 725
Handbook on the Toxicology of Metals, Fifth Edition, Volume I: General Considerations is the first volume of a two-volume work that gives an overview and covers topics of general importance including reviews of various health effects of trace metals. The book emphasizes toxic effects in humans, along with discussions on the toxic effects of animals and biological systems in vitro when relevant. The book has been systematically updated with the latest studies and advances in technology and contains several new chapters. As a multidisciplinary resource that integrates both human and environmental toxicology, the book is a comprehensive and valuable reference for toxicologists, physicians, pharmacologists, and environmental scientists in the fields of environmental, occupational and public health.
1. Handbook on the Toxicology of Metals - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page iv 7. List of reviewers - p. Page viii 8. Preface - p. Page ix 9. List of Illustrations - p. Page x 10. List of Tables - p. Page xi 11. Chapter 1 : Toxicology of metals: Overview, definitions, concepts, and trends∗ - p. Page xi 12. Chapter 2 : General chemistry of metals, sampling, analytical methods, and speciation∗ - p. Page 13 13. Chapter 3 : Exposure, dose, and toxicokinetics of metals∗ - p. Page 49 14. Chapter 4 : Toxicity of metal and metal oxide nanoparticles - p. Page 82 15. Chapter 5 : Toxicity of metals released from implanted medical devices - p. Page 121 16. Chapter 6 : Metals and air pollution - p. Page 135 17. Chapter 7 : Toxic metals in food - p. Page 177 18. Chapter 8 : Interaction of toxic metals with the gut microbiome - p. Page 203 19. Chapter 9 : Biological monitoring of metals and biomarkers∗ - p. Page 216 20. Chapter 10 : Computational modeling and dosimetry of metals - p. Page 233 21. Chapter 11 : Selected molecular mechanisms of metal toxicity and carcinogenicity - p. Page 250 22. Chapter 12 : Effects of metals on extracellular vesicle signaling - p. Page 272 23. Chapter 13 : General considerations of dose-effect and dose-response relationships∗ - p. Page 294 24. Chapter 14 : Interactions and mixtures in metal toxicology - p. Page 317 25. Chapter 15 : Gene–environment interactions and metal toxicity - p. Page 342 26. Chapter 16 : Epidemiological approaches to metal toxicology∗ - p. Page 364 27. Chapter 17 : Essential metals: Assessing risks from deficiency and toxicity - p. Page 382 28. Chapter 18 : The interaction of metals and the skin: The good, bad, and the ugly - p. Page 405 29. Chapter 19 : Metals and the respiratory tract - p. Page 418 30. Chapter 20 : Neurotoxicology of metals - p. Page 439 31. Chapter 21 : Cardiovascular disease - p. Page 456 32. Chapter 22 : Renal effects of exposure to metals - p. Page 479 33. Chapter 23 : Carcinogenicity of metal compounds - p. Page 502 34. Chapter 24 : Immunotoxicology of metals - p. Page 536 35. Chapter 25 : Effects of metallic elements on reproduction and development - p. Page 558 36. Chapter 26 : Ecotoxicology of metals—sources, transport, and effects on the ecosystem - p. Page 587 37. Chapter 27 : Risk assessment for metal exposures - p. Page 623 38. Chapter 28 : Diagnosis and treatment of metal poisoning general aspects∗ - p. Page 659 39. Chapter 29 : Principles for prevention of the toxic effects of metals - p. Page 681 40. Chapter 30 : Metal toxicology in low-income and lower-middle-income countries∗ - p. Page 701 41. Index - p. Page 725
