Thanks to advances in Anti-Retrovial Drugs (ARTs), HIV is treatable and those who have the disease are often able to lead a normal life. However, as a chronic (and incurable) infectious disease, HIV positive patients are susceptible to neuropsychiatric complications. These complications reduce the quality of life for the individual and exponentially increases the cost of medical care and medications to treat both conditions. Neuropsychiatric Complications of HIV: A Challenging Health Concern examines these neuropsychiatric complications prevalent in those who are HIV positive, providing clinical correlation, translational significance, and details guides to neurocognitive assessment, brain imaging, and related neuropharmacology.Written for clinicians, researchers, and students working with HIV and AIDS, the book begins with the biology of HIV, a complete look at available ARTs and antibodies, as well as diagnostics tools for HIV. It continues on to the epidemiology of NeuroAIDs and the manifestations of it—cognitive deficits, dementia, depression, agitation, psychosis, and cognitive slowing.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Front Matter - p. iii 6. Copyright - p. iii 7. Dedication - p. iii 8. Contributors - p. xv 9. Foreword - p. xix 10. Preface - p. xxv 11. Acknowledgments - p. xxvi 12. Chapter 1. The neurobiology of human immunodeficiency virus infections - p. 1 13. Chapter 2. HIV-1-mediated neuropsychiatric complications: Diagnosis and management - p. 25 14. Chapter 3. Neuropsychiatric complications among elderly people living with HIV - p. 51 15. Chapter 4. Epidemiology of neuropsychiatric complications in HIV - p. 77 16. Chapter 5. Role of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) genes in neuro-HIV - p. 115 17. Chapter 6. Genetics and epigenetics of NeuroAIDS - p. 125 18. Chapter 7. Dementia and HIV infection - p. 147 19. Chapter 8. BBB and neuroinflammation - p. 171 20. Chapter 9. Neurological manifestations and neuropharmacology of HIV/AIDS - p. 195 21. Chapter 10. Traumatic brain injury: An emerging threat for HIV-associated neurocognitive disorder - p. 213 22. Drosophila as a model to study NeuroHIV: Insights from sleep function - p. 235 23. Chapter 12. Human immunodeficiency virus and antibodies: Catch 22 - p. 251 24. Chapter 13. Elite neutralizers: An open eye for HIV vaccine development - p. 273 25. Chapter 14. Neuro AIDS: Neuro-invasion and novel therapeutic approaches - p. 291 26. Chapter 15. HIV-1 infection-associated neurological disorders and therapeutic role of phytochemicals - p. 331 27. Index - p. 355
Thanks to advances in Anti-Retrovial Drugs (ARTs), HIV is treatable and those who have the disease are often able to lead a normal life. However, as a chronic (and incurable) infectious disease, HIV positive patients are susceptible to neuropsychiatric complications. These complications reduce the quality of life for the individual and exponentially increases the cost of medical care and medications to treat both conditions. Neuropsychiatric Complications of HIV: A Challenging Health Concern examines these neuropsychiatric complications prevalent in those who are HIV positive, providing clinical correlation, translational significance, and details guides to neurocognitive assessment, brain imaging, and related neuropharmacology.Written for clinicians, researchers, and students working with HIV and AIDS, the book begins with the biology of HIV, a complete look at available ARTs and antibodies, as well as diagnostics tools for HIV. It continues on to the epidemiology of NeuroAIDs and the manifestations of it—cognitive deficits, dementia, depression, agitation, psychosis, and cognitive slowing.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Front Matter - p. iii 6. Copyright - p. iii 7. Dedication - p. iii 8. Contributors - p. xv 9. Foreword - p. xix 10. Preface - p. xxv 11. Acknowledgments - p. xxvi 12. Chapter 1. The neurobiology of human immunodeficiency virus infections - p. 1 13. Chapter 2. HIV-1-mediated neuropsychiatric complications: Diagnosis and management - p. 25 14. Chapter 3. Neuropsychiatric complications among elderly people living with HIV - p. 51 15. Chapter 4. Epidemiology of neuropsychiatric complications in HIV - p. 77 16. Chapter 5. Role of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) genes in neuro-HIV - p. 115 17. Chapter 6. Genetics and epigenetics of NeuroAIDS - p. 125 18. Chapter 7. Dementia and HIV infection - p. 147 19. Chapter 8. BBB and neuroinflammation - p. 171 20. Chapter 9. Neurological manifestations and neuropharmacology of HIV/AIDS - p. 195 21. Chapter 10. Traumatic brain injury: An emerging threat for HIV-associated neurocognitive disorder - p. 213 22. Drosophila as a model to study NeuroHIV: Insights from sleep function - p. 235 23. Chapter 12. Human immunodeficiency virus and antibodies: Catch 22 - p. 251 24. Chapter 13. Elite neutralizers: An open eye for HIV vaccine development - p. 273 25. Chapter 14. Neuro AIDS: Neuro-invasion and novel therapeutic approaches - p. 291 26. Chapter 15. HIV-1 infection-associated neurological disorders and therapeutic role of phytochemicals - p. 331 27. Index - p. 355
