For nearly 40 years, Perez and Brady's Principles and Practice of Radiation Oncology has been the authoritative ‘book-of-record’ for the field of radiation oncology. Covering both the biological and physical science aspects of this complex field as well as site-specific information on the integrated, multidisciplinary management of patients with cancer, Perez & Brady continues to be the most comprehensive reference available for radiation oncologists and radiation oncology residents. Under the editorial leadership of Drs. Edward C. Halperin, David E. Wazer, and expert associate editors Drs. Brian C. Baumann, Rachel C. Blitzblau, and Natia Esiashvili, the fully revised 8th Edition, now known as Perez, Brady, Halperin, and Wazer’s Principles and Practice of Radiation Oncology, is available as a two-volume hardcover edition: Volume 1 covers The Scientific, Technological, Economic, and Ethical Basis of Radiation Oncology, while Volume 2 covers The Clinical Practice of Radiation Oncology.
1. Cover - p. i 2. Half Title Page - p. i 3. Editors - p. ii 4. Title Page - p. iii 5. Copyright Page - p. iv 6. Dedication - p. v 7. Contributors - p. vi 8. Preface: The Past and Future of Principles and Practice of Radiation Oncology - p. xvi 9. Acknowledgments - p. xviii 10. Contents - p. xix 11. Volume I The Scientific, Technological, Economic, and Ethical Basis of Radiation Oncology - p. 1 12. Section I Overview and Basic Science of Radiation Oncology - p. 1 13. 1. The Discipline of Radiation Oncology - p. 2 14. Part A: Cancer Biology - p. 97 15. 2. Molecular Cancer and Radiation Biology - p. 97 16. 3. Biologic Basics of Radiation Oncology - p. 116 17. 4. Molecular Pathophysiology of Tumors - p. 134 18. 5. Precision Medicine as Applied to Radiation Oncology - p. 152 19. Part B: Medical Radiation Physics and Dosimetry - p. 169 20. 6. Principles of Radiation Physics and Dosimetry - p. 169 21. 7. Patient Positioning Methods: Immobilization, Stabilization, and Monitoring - p. 200 22. 8. Photon External-Beam Dosimetry and Two-Dimensional Radiation Treatment Planning - p. 229 23. 9. Electron-Beam Therapy Dosimetry, Treatment Planning, and Techniques - p. 255 24. 10. Conformal and Intensity-Modulated Radiation Therapy Physics: Treatment Planning and Techniques, and Clinical Applications - p. 280 25. 11. Physics and Dosimetry of Proton Therapy - p. 303 26. Section II Techniques, Modalities, and Modifiers in Radiation Oncology - p. 315 27. 12. Late Effects, QUANTEC, and HyTEC - p. 316 28. 13. Quality Assurance and Error Avoidance in Radiation Therapy - p. 359 29. 14. Methodology of Clinical Trials - p. 375 30. 15. Stem Cell Transplantation and Radiation Therapy Techniques - p. 405 31. 16. Stereotactic Irradiation of Tumors of the Central Nervous System - p. 424 32. 17. Stereotactic Irradiation of Tumors Outside the Central Nervous System and Oligometastases - p. 440 33. 18. High-Dose, Ultra-High Dose Rate (FLASH), and Spatially Fractionated Radiotherapy - p. 450 34. 19. Intraoperative Radiotherapy - p. 461 35. 20. Particle Therapy: Protons, Heavy Ions, and Neutrons - p. 471 36. 21. Physics and Radiobiology of Brachytherapy - p. 504 37. 22. Clinical Applications of Brachytherapy: Low Dose Rate and Pulsed Dose Rate - p. 555 38. 23. The Physics and Dosimetry of High-Dose Rate Brachytherapy - p. 581 39. 24. Clinical Aspects and Applications of High-Dose-Rate Brachytherapy - p. 597 40. 25. Beyond the Beam: Radiopharmaceutical Therapy - p. 616 41. 26. Radiation Therapy and the Immune System - p. 633 42. 27. Hyperthermia - p. 656 43. 28. Reirradiation - p. 667 44. 29. Chemical Modifiers of Radiation Response - p. 677 45. 30. Oncologic Imaging and Oncologic Anatomy - p. 687 46. 31. Basic Concepts of Chemotherapy and Irradiation Interaction - p. 712 47. 32. Artificial Intelligence and Data Science as Applied to Radiation Oncology - p. 726 48. Section III Policy, Economics, Education, Ethics, and Technology Assessment - p. 745 49. 33. Technology Assessment, Outcome Analysis Research, Comparative Effectiveness, and Evidence-Based Radiation Oncology - p. 746 50. 34. Global Radiation Oncology - p. 753 51. 35. Radiation Oncology Undergraduate, Graduate, and Continuing Medical Education - p. 769 52. 36. Ethics, Professional Values, and Legal Considerations in Radiation Oncology - p. 812 53. 37. Health Economics and Health Policy - p. 822 54. 38. Economic, Gender, and Racial Disparity in Radiation Oncology - p. 843 55. Volume II The Clinical Practice of Radiation Oncology - p. 853 56. Section IV Clinical Radiation Oncology - p. 853 57. Part A: Skin - p. 854 58. 39. Skin - p. 854 59. Part B: Central Nervous System - p. 868 60. 40. Primary Intracranial Neoplasms - p. 868 61. 41. Fractionated Radiation Therapy and Stereotactic Radiosurgery for Pituitary Adenomas - p. 912 62. 42. Primary Base of Skull Tumors - p. 922 63. 43. Spinal Canal Tumors - p. 946 64. Part C: Head and Neck - p. 959 65. 44. Adult Tumors of the Eye and Orbit - p. 959 66. 45. Ear - p. 973 67. 46. Locally Advanced Squamous Carcinoma of the Head and Neck - p. 983 68. 47. Nasopharynx - p. 1001 69. 48. Cancer of the Nasal Cavity and Paranasal Sinuses - p. 1040 70. 49. Salivary Glands - p. 1061 71. 50. Oral Cavity - p. 1092 72. 51. Oropharynx - p. 1123 73. 52. Hypopharynx - p. 1143 74. 53. Laryngeal Cancer - p. 1160 75. 54. Unusual Nonepithelial Tumors of the Head and Neck - p. 1181 76. 55. Neck Cancer, Including Carcinoma of Unknown Primary - p. 1216 77. 56. Thyroid Cancer - p. 1235 78. Part D: Thorax - p. 1251 79. 57. Lung Cancer - p. 1251 80. 58. Mediastinum and Trachea - p. 1279 81. 59. Esophageal Cancer - p. 1316 82. 60. Tumors of the Heart, Pericardium, and Great Vessels - p. 1361 83. Part E: Breast - p. 1372 84. 61. Breast Cancer: Stage Tis - p. 1372 85. 62. Breast Cancer: Early Stage - p. 1386 86. 63. Breast Cancer: Locally Advanced and Locally Recurrent - p. 1455 87. Part F: Gastrointestinal - p. 1489 88. 64. Stomach Cancer - p. 1489 89. 65. Pancreatic Cancer - p. 1523 90. 66. Cancer of the Liver and Hepatobiliary Tract - p. 1541 91. 67. Cancer of the Colon and Rectum - p. 1568 92. 68. Anal Cancer - p. 1595 93. Part G: Urinary Tract - p. 1611 94. 69. Cancer of the Kidney, Renal Pelvis, and Ureter - p. 1611 95. 70. Adjuvant and Neoadjuvant Radiation Therapy for Locally Advanced Bladder Cancer - p. 1629 96. 71. Bladder Cancer - p. 1637 97. Part H: Male Genitourinary - p. 1665 98. 72. Low-Risk Prostate Cancer - p. 1665 99. 73. Management of Intermediate- and High-Risk Prostate Cancer - p. 1703 100. 74. Testicular Cancer - p. 1731 101. 75. Cancer of the Penis and Male Urethra - p. 1747 102. Part I: Gynecologic - p. 1762 103. 76. Cancer of the Uterine Cervix - p. 1762 104. 77. Endometrial Cancer - p. 1828 105. 78. Ovarian and Fallopian Tube Cancer - p. 1854 106. 79. Vaginal Cancer - p. 1878 107. 80. Female Urethral - p. 1910 108. 81. Carcinoma of the Vulva - p. 1922 109. Part J: Adrenal and Retroperitoneal Tumors - p. 1939 110. 82. Retroperitoneum - p. 1939 111. 83. Adrenal Cancer - p. 1951 112. Part K: Lymphoma and Hematologic Tumors - p. 1956 113. 84. Hodgkin Lymphoma - p. 1956 114. 85. Non-Hodgkin Lymphomas - p. 1974 115. 86. Primary Cutaneous Lymphomas - p. 1998 116. 87. Leukemia - p. 2012 117. 88. Plasma Cell Neoplasms: Multiple Myeloma and Solitary Plasmacytomas - p. 2037 118. Part L: Soft Tissue - p. 2054 119. 89. Soft Tissue Sarcoma (Excluding Retroperitoneum) - p. 2054 120. Part M: Pediatric - p. 2072 121. 90. Central Nervous System Tumors in Children - p. 2072 122. 91. Wilms Tumor - p. 2103 123. 92. Neuroblastoma - p. 2116 124. 93. Rhabdomyosarcoma - p. 2129 125. 94. Nonrhabdomyosarcoma Soft Tissue Sarcoma in Children - p. 2144 126. 95. Osteosarcoma and Other Primary Tumors of Bone - p. 2157 127. 96. Ewing Sarcoma - p. 2164 128. 97. Lymphomas in Children, Adolescents, and Young Adults - p. 2176 129. 98. Retinoblastoma - p. 2201 130. 99. Rare Tumors in Children - p. 2218 131. Part N: Benign Diseases - p. 2237 132. 100. Nonmalignant Diseases - p. 2237 133. Section V Palliative and Supportive Care - p. 2261 134. 101. Palliation of Brain Metastases - p. 2262 135. 102. Palliation of Vertebral and Spinal Cord Metastases - p. 2277 136. 103. Palliation of Bone Metastases - p. 2288 137. 104. Palliation of Visceral Recurrences and Metastases and Treatment of Oligometastatic Disease - p. 2302 138. 105. Cancer Pain: Assessment and Management - p. 2314 139. 106. Palliative and Supportive Care - p. 2322 140. 107. Management of Radiation Side Effects - p. 2335 141. Index - p. I-1
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For nearly 40 years, Perez and Brady's Principles and Practice of Radiation Oncology has been the authoritative ‘book-of-record’ for the field of radiation oncology. Covering both the biological and physical science aspects of this complex field as well as site-specific information on the integrated, multidisciplinary management of patients with cancer, Perez & Brady continues to be the most comprehensive reference available for radiation oncologists and radiation oncology residents. Under the editorial leadership of Drs. Edward C. Halperin, David E. Wazer, and expert associate editors Drs. Brian C. Baumann, Rachel C. Blitzblau, and Natia Esiashvili, the fully revised 8th Edition, now known as Perez, Brady, Halperin, and Wazer’s Principles and Practice of Radiation Oncology, is available as a two-volume hardcover edition: Volume 1 covers The Scientific, Technological, Economic, and Ethical Basis of Radiation Oncology, while Volume 2 covers The Clinical Practice of Radiation Oncology.
1. Cover - p. i 2. Half Title Page - p. i 3. Editors - p. ii 4. Title Page - p. iii 5. Copyright Page - p. iv 6. Dedication - p. v 7. Contributors - p. vi 8. Preface: The Past and Future of Principles and Practice of Radiation Oncology - p. xvi 9. Acknowledgments - p. xviii 10. Contents - p. xix 11. Volume I The Scientific, Technological, Economic, and Ethical Basis of Radiation Oncology - p. 1 12. Section I Overview and Basic Science of Radiation Oncology - p. 1 13. 1. The Discipline of Radiation Oncology - p. 2 14. Part A: Cancer Biology - p. 97 15. 2. Molecular Cancer and Radiation Biology - p. 97 16. 3. Biologic Basics of Radiation Oncology - p. 116 17. 4. Molecular Pathophysiology of Tumors - p. 134 18. 5. Precision Medicine as Applied to Radiation Oncology - p. 152 19. Part B: Medical Radiation Physics and Dosimetry - p. 169 20. 6. Principles of Radiation Physics and Dosimetry - p. 169 21. 7. Patient Positioning Methods: Immobilization, Stabilization, and Monitoring - p. 200 22. 8. Photon External-Beam Dosimetry and Two-Dimensional Radiation Treatment Planning - p. 229 23. 9. Electron-Beam Therapy Dosimetry, Treatment Planning, and Techniques - p. 255 24. 10. Conformal and Intensity-Modulated Radiation Therapy Physics: Treatment Planning and Techniques, and Clinical Applications - p. 280 25. 11. Physics and Dosimetry of Proton Therapy - p. 303 26. Section II Techniques, Modalities, and Modifiers in Radiation Oncology - p. 315 27. 12. Late Effects, QUANTEC, and HyTEC - p. 316 28. 13. Quality Assurance and Error Avoidance in Radiation Therapy - p. 359 29. 14. Methodology of Clinical Trials - p. 375 30. 15. Stem Cell Transplantation and Radiation Therapy Techniques - p. 405 31. 16. Stereotactic Irradiation of Tumors of the Central Nervous System - p. 424 32. 17. Stereotactic Irradiation of Tumors Outside the Central Nervous System and Oligometastases - p. 440 33. 18. High-Dose, Ultra-High Dose Rate (FLASH), and Spatially Fractionated Radiotherapy - p. 450 34. 19. Intraoperative Radiotherapy - p. 461 35. 20. Particle Therapy: Protons, Heavy Ions, and Neutrons - p. 471 36. 21. Physics and Radiobiology of Brachytherapy - p. 504 37. 22. Clinical Applications of Brachytherapy: Low Dose Rate and Pulsed Dose Rate - p. 555 38. 23. The Physics and Dosimetry of High-Dose Rate Brachytherapy - p. 581 39. 24. Clinical Aspects and Applications of High-Dose-Rate Brachytherapy - p. 597 40. 25. Beyond the Beam: Radiopharmaceutical Therapy - p. 616 41. 26. Radiation Therapy and the Immune System - p. 633 42. 27. Hyperthermia - p. 656 43. 28. Reirradiation - p. 667 44. 29. Chemical Modifiers of Radiation Response - p. 677 45. 30. Oncologic Imaging and Oncologic Anatomy - p. 687 46. 31. Basic Concepts of Chemotherapy and Irradiation Interaction - p. 712 47. 32. Artificial Intelligence and Data Science as Applied to Radiation Oncology - p. 726 48. Section III Policy, Economics, Education, Ethics, and Technology Assessment - p. 745 49. 33. Technology Assessment, Outcome Analysis Research, Comparative Effectiveness, and Evidence-Based Radiation Oncology - p. 746 50. 34. Global Radiation Oncology - p. 753 51. 35. Radiation Oncology Undergraduate, Graduate, and Continuing Medical Education - p. 769 52. 36. Ethics, Professional Values, and Legal Considerations in Radiation Oncology - p. 812 53. 37. Health Economics and Health Policy - p. 822 54. 38. Economic, Gender, and Racial Disparity in Radiation Oncology - p. 843 55. Volume II The Clinical Practice of Radiation Oncology - p. 853 56. Section IV Clinical Radiation Oncology - p. 853 57. Part A: Skin - p. 854 58. 39. Skin - p. 854 59. Part B: Central Nervous System - p. 868 60. 40. Primary Intracranial Neoplasms - p. 868 61. 41. Fractionated Radiation Therapy and Stereotactic Radiosurgery for Pituitary Adenomas - p. 912 62. 42. Primary Base of Skull Tumors - p. 922 63. 43. Spinal Canal Tumors - p. 946 64. Part C: Head and Neck - p. 959 65. 44. Adult Tumors of the Eye and Orbit - p. 959 66. 45. Ear - p. 973 67. 46. Locally Advanced Squamous Carcinoma of the Head and Neck - p. 983 68. 47. Nasopharynx - p. 1001 69. 48. Cancer of the Nasal Cavity and Paranasal Sinuses - p. 1040 70. 49. Salivary Glands - p. 1061 71. 50. Oral Cavity - p. 1092 72. 51. Oropharynx - p. 1123 73. 52. Hypopharynx - p. 1143 74. 53. Laryngeal Cancer - p. 1160 75. 54. Unusual Nonepithelial Tumors of the Head and Neck - p. 1181 76. 55. Neck Cancer, Including Carcinoma of Unknown Primary - p. 1216 77. 56. Thyroid Cancer - p. 1235 78. Part D: Thorax - p. 1251 79. 57. Lung Cancer - p. 1251 80. 58. Mediastinum and Trachea - p. 1279 81. 59. Esophageal Cancer - p. 1316 82. 60. Tumors of the Heart, Pericardium, and Great Vessels - p. 1361 83. Part E: Breast - p. 1372 84. 61. Breast Cancer: Stage Tis - p. 1372 85. 62. Breast Cancer: Early Stage - p. 1386 86. 63. Breast Cancer: Locally Advanced and Locally Recurrent - p. 1455 87. Part F: Gastrointestinal - p. 1489 88. 64. Stomach Cancer - p. 1489 89. 65. Pancreatic Cancer - p. 1523 90. 66. Cancer of the Liver and Hepatobiliary Tract - p. 1541 91. 67. Cancer of the Colon and Rectum - p. 1568 92. 68. Anal Cancer - p. 1595 93. Part G: Urinary Tract - p. 1611 94. 69. Cancer of the Kidney, Renal Pelvis, and Ureter - p. 1611 95. 70. Adjuvant and Neoadjuvant Radiation Therapy for Locally Advanced Bladder Cancer - p. 1629 96. 71. Bladder Cancer - p. 1637 97. Part H: Male Genitourinary - p. 1665 98. 72. Low-Risk Prostate Cancer - p. 1665 99. 73. Management of Intermediate- and High-Risk Prostate Cancer - p. 1703 100. 74. Testicular Cancer - p. 1731 101. 75. Cancer of the Penis and Male Urethra - p. 1747 102. Part I: Gynecologic - p. 1762 103. 76. Cancer of the Uterine Cervix - p. 1762 104. 77. Endometrial Cancer - p. 1828 105. 78. Ovarian and Fallopian Tube Cancer - p. 1854 106. 79. Vaginal Cancer - p. 1878 107. 80. Female Urethral - p. 1910 108. 81. Carcinoma of the Vulva - p. 1922 109. Part J: Adrenal and Retroperitoneal Tumors - p. 1939 110. 82. Retroperitoneum - p. 1939 111. 83. Adrenal Cancer - p. 1951 112. Part K: Lymphoma and Hematologic Tumors - p. 1956 113. 84. Hodgkin Lymphoma - p. 1956 114. 85. Non-Hodgkin Lymphomas - p. 1974 115. 86. Primary Cutaneous Lymphomas - p. 1998 116. 87. Leukemia - p. 2012 117. 88. Plasma Cell Neoplasms: Multiple Myeloma and Solitary Plasmacytomas - p. 2037 118. Part L: Soft Tissue - p. 2054 119. 89. Soft Tissue Sarcoma (Excluding Retroperitoneum) - p. 2054 120. Part M: Pediatric - p. 2072 121. 90. Central Nervous System Tumors in Children - p. 2072 122. 91. Wilms Tumor - p. 2103 123. 92. Neuroblastoma - p. 2116 124. 93. Rhabdomyosarcoma - p. 2129 125. 94. Nonrhabdomyosarcoma Soft Tissue Sarcoma in Children - p. 2144 126. 95. Osteosarcoma and Other Primary Tumors of Bone - p. 2157 127. 96. Ewing Sarcoma - p. 2164 128. 97. Lymphomas in Children, Adolescents, and Young Adults - p. 2176 129. 98. Retinoblastoma - p. 2201 130. 99. Rare Tumors in Children - p. 2218 131. Part N: Benign Diseases - p. 2237 132. 100. Nonmalignant Diseases - p. 2237 133. Section V Palliative and Supportive Care - p. 2261 134. 101. Palliation of Brain Metastases - p. 2262 135. 102. Palliation of Vertebral and Spinal Cord Metastases - p. 2277 136. 103. Palliation of Bone Metastases - p. 2288 137. 104. Palliation of Visceral Recurrences and Metastases and Treatment of Oligometastatic Disease - p. 2302 138. 105. Cancer Pain: Assessment and Management - p. 2314 139. 106. Palliative and Supportive Care - p. 2322 140. 107. Management of Radiation Side Effects - p. 2335 141. Index - p. I-1
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