This new book, from the editor of the highly successful Pharmaceutical Analysis, sets out to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. It focuses less on prototypes of drugs that perhaps never came to market and more on the drugs currently in use. The emphasis in the book is on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target. Important physicochemical properties include pKa and partition coefficient and the properties of the structural elements within the drug which provide interactions with the target via a range of intermolecular forces. The last fifteen years has seen a great advance in the knowledge of protein structures and a strong emphasis is given to the interaction of drugs with proteins which shape the majority of drug mechanisms.
Features:
This new book, from the editor of the highly successful Pharmaceutical Analysis, sets out to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. It focuses less on prototypes of drugs that perhaps never came to market and more on the drugs currently in use. The emphasis in the book is on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target. Important physicochemical properties include pKa and partition coefficient and the properties of the structural elements within the drug which provide interactions with the target via a range of intermolecular forces. The last fifteen years has seen a great advance in the knowledge of protein structures and a strong emphasis is given to the interaction of drugs with proteins which shape the majority of drug mechanisms.
Features:
1. Cover 2. Title Page 3. Front matter 4. Copyright 5. Preface 6. Contributors 7. Table of Contents 8. Chapter 1: Bond type and bond strength 9. Chapter 2: Hydrocarbons: alkanes, alkenes, aromatic and alkylhalides 10. Chapter 3: Amines 11. Chapter 4: Neutral and acidic nitrogen compounds 12. Chapter 5: Oxygen- and sulphur-containing functional groups 13. Chapter 6: Protein structure and its relevance to drug action 14. Chapter 7: DNA structure and its importance to drug action 15. Chapter 8: Drug absorption, distribution, metabolism and excretion 16. Chapter 9: Structure, activity and drug design 17. Chapter 10: Drugs affecting the adrenergic system 18. Chapter 11: Drugs exerting non-adrenergic effects on cardiac output and vascular tone 19. Chapter 12: Drugs interacting with mammalian enzymes 20. Chapter 13: Central nervous system depressants 21. Chapter 14: Analgesics 22. Chapter 15: Local anaesthetics 23. Chapter 16: Anticholinergic agents 24. Chapter 17: Antihistamine drugs 25. Chapter 18: CNS stimulants and CNS-active drugs affecting the serotonergic system 26. Chapter 19: Drugs affecting haemostasis and thrombosis 27. Chapter 20: Drugs affecting the endocrine system 28. Chapter 21: Anticancer drugs 29. Chapter 22: Antimicrobial chemotherapy 30. Chapter 23: Antiviral drugs 31. Chapter 24: Antifungal chemotherapy 32. Chapter 25: Antiparasitic drugs 33. Chapter 26: Vitamins and minerals 34. Chapter 27: Biotechnologically produced products 35. Chapter 28: Drug and gene delivery systems 36. Chapter 29: The tonic and toxic effects of alcohol and its metabolites 37. Index
No hay muestra disponible
No hay ficha técnica disponible
This new book, from the editor of the highly successful Pharmaceutical Analysis, sets out to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. It focuses less on prototypes of drugs that perhaps never came to market and more on the drugs currently in use. The emphasis in the book is on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target. Important physicochemical properties include pKa and partition coefficient and the properties of the structural elements within the drug which provide interactions with the target via a range of intermolecular forces. The last fifteen years has seen a great advance in the knowledge of protein structures and a strong emphasis is given to the interaction of drugs with proteins which shape the majority of drug mechanisms.
Features:
This new book, from the editor of the highly successful Pharmaceutical Analysis, sets out to define the area of pharmaceutical chemistry as distinct from medicinal chemistry. It focuses less on prototypes of drugs that perhaps never came to market and more on the drugs currently in use. The emphasis in the book is on the physicochemical properties of drug molecules and, in so far as they are known, the way that these properties govern the interaction of the drug with its target. Important physicochemical properties include pKa and partition coefficient and the properties of the structural elements within the drug which provide interactions with the target via a range of intermolecular forces. The last fifteen years has seen a great advance in the knowledge of protein structures and a strong emphasis is given to the interaction of drugs with proteins which shape the majority of drug mechanisms.
Features:
1. Cover 2. Title Page 3. Front matter 4. Copyright 5. Preface 6. Contributors 7. Table of Contents 8. Chapter 1: Bond type and bond strength 9. Chapter 2: Hydrocarbons: alkanes, alkenes, aromatic and alkylhalides 10. Chapter 3: Amines 11. Chapter 4: Neutral and acidic nitrogen compounds 12. Chapter 5: Oxygen- and sulphur-containing functional groups 13. Chapter 6: Protein structure and its relevance to drug action 14. Chapter 7: DNA structure and its importance to drug action 15. Chapter 8: Drug absorption, distribution, metabolism and excretion 16. Chapter 9: Structure, activity and drug design 17. Chapter 10: Drugs affecting the adrenergic system 18. Chapter 11: Drugs exerting non-adrenergic effects on cardiac output and vascular tone 19. Chapter 12: Drugs interacting with mammalian enzymes 20. Chapter 13: Central nervous system depressants 21. Chapter 14: Analgesics 22. Chapter 15: Local anaesthetics 23. Chapter 16: Anticholinergic agents 24. Chapter 17: Antihistamine drugs 25. Chapter 18: CNS stimulants and CNS-active drugs affecting the serotonergic system 26. Chapter 19: Drugs affecting haemostasis and thrombosis 27. Chapter 20: Drugs affecting the endocrine system 28. Chapter 21: Anticancer drugs 29. Chapter 22: Antimicrobial chemotherapy 30. Chapter 23: Antiviral drugs 31. Chapter 24: Antifungal chemotherapy 32. Chapter 25: Antiparasitic drugs 33. Chapter 26: Vitamins and minerals 34. Chapter 27: Biotechnologically produced products 35. Chapter 28: Drug and gene delivery systems 36. Chapter 29: The tonic and toxic effects of alcohol and its metabolites 37. Index
No hay muestra disponible
No hay ficha técnica disponible
