This issue of Clinics in Chest Medicine, edited by Dr. Serpil Erzurum and Dr. Sumita Khatri, is devoted to several key areas of interest related to understanding Asthma and its treatments. Topics covered in this issue include: Epidemiology of the Asthma Epidemic in the 21st Century; Classification of Asthma; Genetics and Epigenetics of Asthma; Pro-Inflammatory Pathways in the Pathogenesis of Asthma; Dysfunction of Bronchomotor Tone Pathways in Asthmatic Airway Smooth Muscle; Systematic Approach to Asthma of Varying Severity; Comorbidities and Non-allergic Triggers in Asthma Exacerbations and Severity; Microbiome in Mechanisms of Asthma; Diet and Metabolism in the Evolution of Asthma and Obesity; The Exposome of Asthma; Life Cycle of Childhood Asthma; Asthma over the Adult Lifecourse, considering Gender and Hormonal Influences; Asthma and Corticosteroid Responses in Childhood and Adult Asthma; Immunomodulators and Biologics; Bronchial Thermoplasty; Population Health Models for Asthma; and The Future of Asthma Care: Personalized Asthma Treatment.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Preface - p. xiii 8. Practical and Conceptual Considerations for the Primary Prevention of Asthma - p. 1 9. Three Major Efforts to Phenotype Asthma: Severe Asthma Research Program, Asthma Disease Endotyping for Personalized Therapeutics, and Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome - p. 13 10. Proinflammatory Pathways in the Pathogenesis of Asthma - p. 29 11. Modulation of Bronchomotor Tone Pathways in Airway Smooth Muscle Function and Bronchomotor Tone in Asthma - p. 51 12. Systematic Approach to Asthma of Varying Severity - p. 59 13. Nonallergic Triggers and Comorbidities in Asthma Exacerbations and Disease Severity - p. 71 14. Microbiome in Mechanisms of Asthma - p. 87 15. Diet and Metabolism in the Evolution of Asthma and Obesity - p. 97 16. The Exposome and Asthma - p. 107 17. Life Cycle of Childhood Asthma: Prenatal, Infancy and Preschool, Childhood, and Adolescence - p. 125 18. Asthma over the Adult Life Course: Gender and Hormonal Influences - p. 149 19. Asthma and Corticosteroid Responses in Childhood and Adult Asthma - p. 163 20. Immunomodulators and Biologics: Beyond Stepped-Care Therapy - p. 179 21. Bronchial Thermoplasty - p. 193 22. The Use of Geographic Data to Improve Asthma Care Delivery and Population Health - p. 209 23. The Future of Asthma Care: Personalized Asthma Treatment - p. 227
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This issue of Clinics in Chest Medicine, edited by Dr. Serpil Erzurum and Dr. Sumita Khatri, is devoted to several key areas of interest related to understanding Asthma and its treatments. Topics covered in this issue include: Epidemiology of the Asthma Epidemic in the 21st Century; Classification of Asthma; Genetics and Epigenetics of Asthma; Pro-Inflammatory Pathways in the Pathogenesis of Asthma; Dysfunction of Bronchomotor Tone Pathways in Asthmatic Airway Smooth Muscle; Systematic Approach to Asthma of Varying Severity; Comorbidities and Non-allergic Triggers in Asthma Exacerbations and Severity; Microbiome in Mechanisms of Asthma; Diet and Metabolism in the Evolution of Asthma and Obesity; The Exposome of Asthma; Life Cycle of Childhood Asthma; Asthma over the Adult Lifecourse, considering Gender and Hormonal Influences; Asthma and Corticosteroid Responses in Childhood and Adult Asthma; Immunomodulators and Biologics; Bronchial Thermoplasty; Population Health Models for Asthma; and The Future of Asthma Care: Personalized Asthma Treatment.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xi 7. Preface - p. xiii 8. Practical and Conceptual Considerations for the Primary Prevention of Asthma - p. 1 9. Three Major Efforts to Phenotype Asthma: Severe Asthma Research Program, Asthma Disease Endotyping for Personalized Therapeutics, and Unbiased Biomarkers for the Prediction of Respiratory Disease Outcome - p. 13 10. Proinflammatory Pathways in the Pathogenesis of Asthma - p. 29 11. Modulation of Bronchomotor Tone Pathways in Airway Smooth Muscle Function and Bronchomotor Tone in Asthma - p. 51 12. Systematic Approach to Asthma of Varying Severity - p. 59 13. Nonallergic Triggers and Comorbidities in Asthma Exacerbations and Disease Severity - p. 71 14. Microbiome in Mechanisms of Asthma - p. 87 15. Diet and Metabolism in the Evolution of Asthma and Obesity - p. 97 16. The Exposome and Asthma - p. 107 17. Life Cycle of Childhood Asthma: Prenatal, Infancy and Preschool, Childhood, and Adolescence - p. 125 18. Asthma over the Adult Life Course: Gender and Hormonal Influences - p. 149 19. Asthma and Corticosteroid Responses in Childhood and Adult Asthma - p. 163 20. Immunomodulators and Biologics: Beyond Stepped-Care Therapy - p. 179 21. Bronchial Thermoplasty - p. 193 22. The Use of Geographic Data to Improve Asthma Care Delivery and Population Health - p. 209 23. The Future of Asthma Care: Personalized Asthma Treatment - p. 227
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