Known for its concise, easy-to-read writing style and comprehensive coverage, Cecil Essentials of Medicine has been a favorite of students, residents, and instructors through nine outstanding editions. This revised 10th Edition continues the tradition of excellence with a focus on high-yield core knowledge of key importance to anyone entering or established in the field of internal medicine. Fully revised and updated by editors Edward J. Wing and Fred J. Schiffman, along with other leading teachers and experts in the field, Cecil Essentials remains clinically focused and solidly grounded in basic science.
1. SECTION I: Introduction to Medicine - p. iii 2. List of Illustrations - p. iii 3. List of Tables - p. iii 4. Chapter 1: Introduction to Medicine - p. iii 5. SECTION II: Cardiovascular Disease - p. iii 6. Chapter 2: Structure and Function of the Normal Heart and Blood Vessels - p. iii 7. Chapter 3: Evaluation of the Patient With Cardiovascular Disease - p. g9 8. Chapter 4: Diagnostic Tests and Procedures in the Patient With Cardiovascular Disease - p. g22 9. Chapter 5: Heart Failure and Cardiomyopathy - p. g42 10. Chapter 6: Congenital Heart Disease - p. g53 11. Chapter 7: Valvular Heart Disease - p. g63 12. Chapter 8: Coronary Heart Disease - p. g76 13. Chapter 9: Cardiac Arrhythmias - p. g98 14. Chapter 10: Pericardial and Myocardial Disease - p. g122 15. Chapter 11: Other Cardiac Topics - p. g130 16. Chapter 12: Vascular Diseases and Hypertension - p. g137 17. SECTION III: Pulmonary and Critical Care Medicine - p. g160 18. Chapter 13: Lung in Health and Disease - p. g160 19. Chapter 14: General Approach to Patients With Respiratory Disorders - p. g164 20. Chapter 15: Evaluating Lung Structure and Function - p. g168 21. Chapter 16: Obstructive Lung Diseases - p. g184 22. Chapter 17: Interstitial Lung Diseases - p. g198 23. Chapter 18: Pulmonary Vascular Diseases - p. g215 24. Chapter 19: Disorders of the Pleura, Mediastinum, and Chest Wall - p. g219.e1 25. Chapter 20: Respiratory Failure - p. g224.e1 26. Chapter 21: Transitions in Care From Pediatric to Adult Providers for Individuals With Pulmonary Disease - p. g233 27. SECTION IV: Preoperative and Postoperative Care - p. g238 28. Chapter 22: Preoperative and Postoperative Care - p. g238 29. SECTION V: Renal Disease - p. g249 30. Chapter 23: Renal Structure and Function - p. g249 31. Chapter 24: Approach to the Patient With Renal Disease - p. g257 32. Chapter 25: Fluid and Electrolyte Disorders - p. g267 33. Chapter 26: Glomerular Diseases - p. g281 34. Chapter 27: Major Nonglomerular Disorders of the Kidney - p. g297 35. Chapter 28: Vascular Disorders of the Kidney - p. g309.e1 36. Chapter 29: Acute Kidney Injury - p. g323 37. Chapter 30: Chronic Kidney Disease - p. g332.e1 38. SECTION VI: Gastrointestinal Disease - p. g341 39. Chapter 31: Common Clinical Manifestations of Gastrointestinal Disease: Abdominal Pain - p. g341 40. Chapter 32: Common Clinical Manifestations of Gastrointestinal Disease: Gastrointestinal Hemorrhage - p. g344 41. Chapter 33: Common Clinical Manifestations of Gastrointestinal Disease: Malabsorption - p. g350 42. Chapter 34: Common Clinical Manifestations of Gastrointestinal Disease: Diarrhea - p. g357 43. Chapter 35: Endoscopic and Imaging Procedures - p. g362 44. Chapter 36: Esophageal Disorders - p. g369 45. Chapter 37: Diseases of the Stomach and Duodenum - p. g378 46. Chapter 38: Inflammatory Bowel Disease - p. g391 47. Chapter 39: Diseases of the Pancreas - p. g400 48. SECTION VII: Diseases of the Liver and Biliary System - p. g415 49. Chapter 40: Laboratory Tests in Liver Diseases - p. g415 50. Chapter 41: Jaundice - p. g419 51. Chapter 42: Acute and Chronic Hepatitis - p. g424 52. Chapter 43: Acute Liver Failure - p. g433 53. Chapter 44: Cirrhosis of the Liver and Its Complications - p. g436 54. Chapter 45: Disorders of the Gallbladder and Biliary Tract - p. g446 55. SECTION VIII: Hematologic Disease - p. g455 56. Chapter 46: Hematopoiesis and Hematopoietic Failure - p. g455 57. Chapter 47: Clonal Disorders of the Hematopoietic Stem Cell - p. g468 58. Chapter 48: Disorders of Red Blood Cells - p. g488 59. Chapter 49: Clinical Disorders of Granulocytes and Monocytes - p. g500 60. Chapter 50: Disorders of Lymphocytes - p. g505 61. Chapter 51: Normal Hemostasis - p. g520 62. Chapter 52: Disorders of Hemostasis: Bleeding - p. g529 63. Chapter 53: Disorders of Hemostasis: Thrombosis - p. g549 64. SECTION IX: Oncologic Disease - p. g561 65. Chapter 54: Cancer Biology - p. g561 66. Chapter 55: Cancer Epidemiology - p. g570 67. Chapter 56: Principles of Cancer Therapy - p. g576 68. Chapter 57: Lung Cancer - p. g582 69. Chapter 58: Gastrointestinal Cancers - p. g588 70. Chapter 59: Genitourinary Cancers - p. g594 71. Chapter 60: Breast Cancer - p. g600 72. Chapter 61: Gynecological Cancer - p. g606 73. Chapter 62: Other Solid Tumors (Head and Neck, Sarcomas, Melanoma, Unknown Primary) - p. g614 74. Chapter 63: Complications of Cancer and Cancer Treatment - p. g619 75. SECTION X: Endocrine Disease and Metabolic Disease - p. g624 76. Chapter 64: Hypothalamic-Pituitary Axis - p. g624 77. Chapter 65: Thyroid Gland - p. g634 78. Chapter 66: Adrenal Gland - p. g643 79. Chapter 67: Male Reproductive Endocrinology - p. g656 80. Chapter 68: Diabetes Mellitus, Hypoglycemia - p. g661 81. Chapter 69: Obesity - p. g677 82. Chapter 70: Malnutrition, Nutritional Assessment, and Nutritional Support in Adult Patients - p. g685 83. Chapter 71: Disorders of Lipid Metabolism - p. g691 84. SECTION XI: Women’s Health - p. g699 85. Chapter 72: Women’s Health Topics - p. g699 86. SECTION XII: Men’s Health - p. g712 87. Chapter 73: Men’s Health Topics - p. g712 88. SECTION XIII: Diseases of Bone and Bone Mineral Metabolism - p. g727 89. Chapter 74: Normal Physiology of Bone and Mineral Homeostasis - p. g727 90. Chapter 75: Disorders of Serum Minerals - p. g738 91. Chapter 76: Metabolic Bone Diseases - p. g746 92. Chapter 77: Osteoporosis - p. g756 93. SECTION XIV: Musculoskeletal and Connective Tissue Disease - p. g765 94. Chapter 78: Approach to the Patient With Rheumatic Disease - p. g765 95. Chapter 79: Rheumatoid Arthritis - p. g770 96. Chapter 80: Spondyloarthritis - p. g777 97. Chapter 81: Systemic Lupus Erythematosus - p. g782 98. Chapter 82: Systemic Sclerosis - p. g792 99. Chapter 83: Systemic Vasculitis - p. g800 100. Chapter 84: Crystal Arthropathies - p. g805 101. Chapter 85: Osteoarthritis - p. g812 102. Chapter 86: Nonarticular Soft Tissue Disorders - p. g817 103. Chapter 87: Rheumatic Manifestations of Systemic Disorders and Sjögren’s Syndrome - p. g821 104. SECTION XV: Infectious Disease - p. g828 105. Chapter 88: Host Defenses Against Infection - p. g828 106. Chapter 89: Laboratory Diagnosis of Infectious Diseases - p. g841 107. Chapter 90: Fever and Febrile Syndromes - p. g847 108. Chapter 91: Bacteremia and Sepsis - p. g857 109. Chapter 92: Infections of the Central Nervous System - p. g864 110. Chapter 93: Infections of the Head and Neck - p. g881 111. Chapter 94: Infections of the Lower Respiratory Tract - p. g886 112. Chapter 95: Infections of the Heart and Blood Vessels - p. g892 113. Chapter 96: Acute Bacterial Skin and Skin Structure Infections - p. g901 114. Chapter 97: Intraabdominal Infections - p. g909 115. Chapter 98: Infectious Diarrhea - p. g914 116. Chapter 99: Infections Involving Bone and Joints - p. g921 117. Chapter 100: Urinary Tract Infections - p. g924 118. Chapter 101: Health Care–Associated Infections - p. g927 119. Chapter 102: Sexually Transmitted Infections - p. g934 120. Chapter 103: Human Immunodeficiency Virus Infection - p. g943 121. Chapter 104: Infections in the Immunocompromised Host - p. g962 122. Chapter 105: Infectious Diseases of Travelers: Protozoal and Helminthic Infections - p. g972 123. SECTION XVI: Neurologic Disease - p. g978.e1 124. Chapter 106: Neurologic Evaluation of the Patient - p. g978.e1 125. Chapter 107: Disorders of Consciousness - p. g985 126. Chapter 108: Disorders of Sleep - p. g991 127. Chapter 109: Cortical Syndromes - p. g996 128. Chapter 110: Dementia and Memory Disturbances - p. g1000 129. Chapter 111: Major Disorders of Mood, Thoughts, and Behavior - p. g1006 130. Chapter 112: Autonomic Nervous System Disorders - p. g1012 131. Chapter 113: Headache, Neck and Back Pain, and Cranial Neuralgias - p. g1016 132. Chapter 114: Disorders of Vision and Hearing - p. g1024 133. Chapter 115: Dizziness and Vertigo - p. g1032 134. Chapter 116: Disorders of the Motor System - p. g1036 135. Chapter 117: Congenital, Developmental, and Neurocutaneous Disorders - p. g1046 136. Chapter 118: Cerebrovascular Disease - p. g1055 137. Chapter 119: Traumatic Brain Injury and Spinal Cord Injury - p. g1067 138. Chapter 120: Epilepsy - p. g1072 139. Chapter 121: Central Nervous System Tumors - p. g1086 140. Chapter 122: Demyelinating and Inflammatory Disorders - p. g1091 141. Chapter 123: Neuromuscular Diseases: Disorders of the Motor Neuron and Plexus and Peripheral Nerve Disease - p. g1100 142. Chapter 124: Muscle Diseases - p. g1109.e1 143. Chapter 125: Neuromuscular Junction Disease - p. g1121 144. SECTION XVII: Geriatrics - p. g1124 145. Chapter 126: The Aging Patient - p. g1124 146. SECTION XVIII: Palliative Care - p. g1138 147. Chapter 127: Palliative Care - p. g1138 148. SECTION XIX: Alcohol and Substance Use - p. g1149 149. Chapter 128: Alcohol and Substance Use - p. g1149 150. APPENDIX - p. g1164 151. Coronavirus Disease 2019 (COVID-19) - p. g1164 152. Index - p. g1164
Known for its concise, easy-to-read writing style and comprehensive coverage, Cecil Essentials of Medicine has been a favorite of students, residents, and instructors through nine outstanding editions. This revised 10th Edition continues the tradition of excellence with a focus on high-yield core knowledge of key importance to anyone entering or established in the field of internal medicine. Fully revised and updated by editors Edward J. Wing and Fred J. Schiffman, along with other leading teachers and experts in the field, Cecil Essentials remains clinically focused and solidly grounded in basic science.
1. SECTION I: Introduction to Medicine - p. iii 2. List of Illustrations - p. iii 3. List of Tables - p. iii 4. Chapter 1: Introduction to Medicine - p. iii 5. SECTION II: Cardiovascular Disease - p. iii 6. Chapter 2: Structure and Function of the Normal Heart and Blood Vessels - p. iii 7. Chapter 3: Evaluation of the Patient With Cardiovascular Disease - p. g9 8. Chapter 4: Diagnostic Tests and Procedures in the Patient With Cardiovascular Disease - p. g22 9. Chapter 5: Heart Failure and Cardiomyopathy - p. g42 10. Chapter 6: Congenital Heart Disease - p. g53 11. Chapter 7: Valvular Heart Disease - p. g63 12. Chapter 8: Coronary Heart Disease - p. g76 13. Chapter 9: Cardiac Arrhythmias - p. g98 14. Chapter 10: Pericardial and Myocardial Disease - p. g122 15. Chapter 11: Other Cardiac Topics - p. g130 16. Chapter 12: Vascular Diseases and Hypertension - p. g137 17. SECTION III: Pulmonary and Critical Care Medicine - p. g160 18. Chapter 13: Lung in Health and Disease - p. g160 19. Chapter 14: General Approach to Patients With Respiratory Disorders - p. g164 20. Chapter 15: Evaluating Lung Structure and Function - p. g168 21. Chapter 16: Obstructive Lung Diseases - p. g184 22. Chapter 17: Interstitial Lung Diseases - p. g198 23. Chapter 18: Pulmonary Vascular Diseases - p. g215 24. Chapter 19: Disorders of the Pleura, Mediastinum, and Chest Wall - p. g219.e1 25. Chapter 20: Respiratory Failure - p. g224.e1 26. Chapter 21: Transitions in Care From Pediatric to Adult Providers for Individuals With Pulmonary Disease - p. g233 27. SECTION IV: Preoperative and Postoperative Care - p. g238 28. Chapter 22: Preoperative and Postoperative Care - p. g238 29. SECTION V: Renal Disease - p. g249 30. Chapter 23: Renal Structure and Function - p. g249 31. Chapter 24: Approach to the Patient With Renal Disease - p. g257 32. Chapter 25: Fluid and Electrolyte Disorders - p. g267 33. Chapter 26: Glomerular Diseases - p. g281 34. Chapter 27: Major Nonglomerular Disorders of the Kidney - p. g297 35. Chapter 28: Vascular Disorders of the Kidney - p. g309.e1 36. Chapter 29: Acute Kidney Injury - p. g323 37. Chapter 30: Chronic Kidney Disease - p. g332.e1 38. SECTION VI: Gastrointestinal Disease - p. g341 39. Chapter 31: Common Clinical Manifestations of Gastrointestinal Disease: Abdominal Pain - p. g341 40. Chapter 32: Common Clinical Manifestations of Gastrointestinal Disease: Gastrointestinal Hemorrhage - p. g344 41. Chapter 33: Common Clinical Manifestations of Gastrointestinal Disease: Malabsorption - p. g350 42. Chapter 34: Common Clinical Manifestations of Gastrointestinal Disease: Diarrhea - p. g357 43. Chapter 35: Endoscopic and Imaging Procedures - p. g362 44. Chapter 36: Esophageal Disorders - p. g369 45. Chapter 37: Diseases of the Stomach and Duodenum - p. g378 46. Chapter 38: Inflammatory Bowel Disease - p. g391 47. Chapter 39: Diseases of the Pancreas - p. g400 48. SECTION VII: Diseases of the Liver and Biliary System - p. g415 49. Chapter 40: Laboratory Tests in Liver Diseases - p. g415 50. Chapter 41: Jaundice - p. g419 51. Chapter 42: Acute and Chronic Hepatitis - p. g424 52. Chapter 43: Acute Liver Failure - p. g433 53. Chapter 44: Cirrhosis of the Liver and Its Complications - p. g436 54. Chapter 45: Disorders of the Gallbladder and Biliary Tract - p. g446 55. SECTION VIII: Hematologic Disease - p. g455 56. Chapter 46: Hematopoiesis and Hematopoietic Failure - p. g455 57. Chapter 47: Clonal Disorders of the Hematopoietic Stem Cell - p. g468 58. Chapter 48: Disorders of Red Blood Cells - p. g488 59. Chapter 49: Clinical Disorders of Granulocytes and Monocytes - p. g500 60. Chapter 50: Disorders of Lymphocytes - p. g505 61. Chapter 51: Normal Hemostasis - p. g520 62. Chapter 52: Disorders of Hemostasis: Bleeding - p. g529 63. Chapter 53: Disorders of Hemostasis: Thrombosis - p. g549 64. SECTION IX: Oncologic Disease - p. g561 65. Chapter 54: Cancer Biology - p. g561 66. Chapter 55: Cancer Epidemiology - p. g570 67. Chapter 56: Principles of Cancer Therapy - p. g576 68. Chapter 57: Lung Cancer - p. g582 69. Chapter 58: Gastrointestinal Cancers - p. g588 70. Chapter 59: Genitourinary Cancers - p. g594 71. Chapter 60: Breast Cancer - p. g600 72. Chapter 61: Gynecological Cancer - p. g606 73. Chapter 62: Other Solid Tumors (Head and Neck, Sarcomas, Melanoma, Unknown Primary) - p. g614 74. Chapter 63: Complications of Cancer and Cancer Treatment - p. g619 75. SECTION X: Endocrine Disease and Metabolic Disease - p. g624 76. Chapter 64: Hypothalamic-Pituitary Axis - p. g624 77. Chapter 65: Thyroid Gland - p. g634 78. Chapter 66: Adrenal Gland - p. g643 79. Chapter 67: Male Reproductive Endocrinology - p. g656 80. Chapter 68: Diabetes Mellitus, Hypoglycemia - p. g661 81. Chapter 69: Obesity - p. g677 82. Chapter 70: Malnutrition, Nutritional Assessment, and Nutritional Support in Adult Patients - p. g685 83. Chapter 71: Disorders of Lipid Metabolism - p. g691 84. SECTION XI: Women’s Health - p. g699 85. Chapter 72: Women’s Health Topics - p. g699 86. SECTION XII: Men’s Health - p. g712 87. Chapter 73: Men’s Health Topics - p. g712 88. SECTION XIII: Diseases of Bone and Bone Mineral Metabolism - p. g727 89. Chapter 74: Normal Physiology of Bone and Mineral Homeostasis - p. g727 90. Chapter 75: Disorders of Serum Minerals - p. g738 91. Chapter 76: Metabolic Bone Diseases - p. g746 92. Chapter 77: Osteoporosis - p. g756 93. SECTION XIV: Musculoskeletal and Connective Tissue Disease - p. g765 94. Chapter 78: Approach to the Patient With Rheumatic Disease - p. g765 95. Chapter 79: Rheumatoid Arthritis - p. g770 96. Chapter 80: Spondyloarthritis - p. g777 97. Chapter 81: Systemic Lupus Erythematosus - p. g782 98. Chapter 82: Systemic Sclerosis - p. g792 99. Chapter 83: Systemic Vasculitis - p. g800 100. Chapter 84: Crystal Arthropathies - p. g805 101. Chapter 85: Osteoarthritis - p. g812 102. Chapter 86: Nonarticular Soft Tissue Disorders - p. g817 103. Chapter 87: Rheumatic Manifestations of Systemic Disorders and Sjögren’s Syndrome - p. g821 104. SECTION XV: Infectious Disease - p. g828 105. Chapter 88: Host Defenses Against Infection - p. g828 106. Chapter 89: Laboratory Diagnosis of Infectious Diseases - p. g841 107. Chapter 90: Fever and Febrile Syndromes - p. g847 108. Chapter 91: Bacteremia and Sepsis - p. g857 109. Chapter 92: Infections of the Central Nervous System - p. g864 110. Chapter 93: Infections of the Head and Neck - p. g881 111. Chapter 94: Infections of the Lower Respiratory Tract - p. g886 112. Chapter 95: Infections of the Heart and Blood Vessels - p. g892 113. Chapter 96: Acute Bacterial Skin and Skin Structure Infections - p. g901 114. Chapter 97: Intraabdominal Infections - p. g909 115. Chapter 98: Infectious Diarrhea - p. g914 116. Chapter 99: Infections Involving Bone and Joints - p. g921 117. Chapter 100: Urinary Tract Infections - p. g924 118. Chapter 101: Health Care–Associated Infections - p. g927 119. Chapter 102: Sexually Transmitted Infections - p. g934 120. Chapter 103: Human Immunodeficiency Virus Infection - p. g943 121. Chapter 104: Infections in the Immunocompromised Host - p. g962 122. Chapter 105: Infectious Diseases of Travelers: Protozoal and Helminthic Infections - p. g972 123. SECTION XVI: Neurologic Disease - p. g978.e1 124. Chapter 106: Neurologic Evaluation of the Patient - p. g978.e1 125. Chapter 107: Disorders of Consciousness - p. g985 126. Chapter 108: Disorders of Sleep - p. g991 127. Chapter 109: Cortical Syndromes - p. g996 128. Chapter 110: Dementia and Memory Disturbances - p. g1000 129. Chapter 111: Major Disorders of Mood, Thoughts, and Behavior - p. g1006 130. Chapter 112: Autonomic Nervous System Disorders - p. g1012 131. Chapter 113: Headache, Neck and Back Pain, and Cranial Neuralgias - p. g1016 132. Chapter 114: Disorders of Vision and Hearing - p. g1024 133. Chapter 115: Dizziness and Vertigo - p. g1032 134. Chapter 116: Disorders of the Motor System - p. g1036 135. Chapter 117: Congenital, Developmental, and Neurocutaneous Disorders - p. g1046 136. Chapter 118: Cerebrovascular Disease - p. g1055 137. Chapter 119: Traumatic Brain Injury and Spinal Cord Injury - p. g1067 138. Chapter 120: Epilepsy - p. g1072 139. Chapter 121: Central Nervous System Tumors - p. g1086 140. Chapter 122: Demyelinating and Inflammatory Disorders - p. g1091 141. Chapter 123: Neuromuscular Diseases: Disorders of the Motor Neuron and Plexus and Peripheral Nerve Disease - p. g1100 142. Chapter 124: Muscle Diseases - p. g1109.e1 143. Chapter 125: Neuromuscular Junction Disease - p. g1121 144. SECTION XVII: Geriatrics - p. g1124 145. Chapter 126: The Aging Patient - p. g1124 146. SECTION XVIII: Palliative Care - p. g1138 147. Chapter 127: Palliative Care - p. g1138 148. SECTION XIX: Alcohol and Substance Use - p. g1149 149. Chapter 128: Alcohol and Substance Use - p. g1149 150. APPENDIX - p. g1164 151. Coronavirus Disease 2019 (COVID-19) - p. g1164 152. Index - p. g1164
