The Handbook of Parkinson’s Disease Mechanisms offers an integrated overview of the fundamental research devoted to understanding its causes and mechanisms, highlighting recent advances and clinical significance. With a strong focus on cellular and animal model studies, this book also examines the etiology, pathophysiology, epidemiology and underlying symptoms of Parkinson’s disease.
Written with an interdisciplinary approach, this book provides thorough research that will be of interest to researchers, clinicians and graduate students interested in neurodegenerative diseases.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xiii 7. Acknowledgments - p. xv 8. Chapter 1. Cross-talk between genetic and environmental factors in Parkinson's disease - p. 1 9. Chapter 2. Neuromelanin: Bridging catecholamine metabolism and neurodegeneration in Parkinson's disease - p. 21 10. Chapter 3. Rodent models for exploring the mechanisms contributing to Parkinson's disease pathophysiology - p. 43 11. Chapter 4. Non-human primate models of Parkinson’s disease and related synucleinopathies - p. 77 12. Chapter 5. Alpha-synuclein spreading in Parkinson's disease - p. 91 13. Chapter 6. The role of mitochondria in the pathogenesis of Parkinson's disease - p. 105 14. Chapter 7. Parkinson's disease: A chronic systemic inflammatory disorder - p. 117 15. Chapter 8. Transcription factor NRF2: New therapeutic approach to modify Parkinson's disease progression - p. 145 16. Chapter 9. Dopamine neurotransmission in Parkinson's disease - p. 171 17. Chapter 10. Morphological plasticity of striatal medium spiny neurons: Its potential contribution to Parkinson's disease pathophysiology - p. 191 18. Chapter 11. Network determinants of motor disability in Parkinson's disease - p. 217 19. Chapter 12. Molecular mechanisms of l-DOPA-induced dyskinesia - p. 235 20. Chapter 13. Cholinergic contributions to Parkinsonian symptoms and l-DOPA-induced dyskinesia - p. 251 21. Chapter 14. Role of the raphe-serotonin system in Parkinson's disease: Compensatory versus maladaptive plasticity - p. 287 22. Chapter 15. Two-factor model of l-DOPA-induced dyskinesia: Bridging early clinical findings with modern mechanistic understanding - p. 299 23. Chapter 16. Network dynamics in rodent models of Parkinson’s disease - p. 321 24. Chapter 17. Reevaluating the role of the STN-GPe network in generating beta synchronized oscillatory activity in parkinsonism - p. 343 25. Chapter 18. Network dynamics in Parkinson's disease: Primate models and patients - p. 357 26. Chapter 19. Cell replacement and gene therapies for Parkinson's disease: A precision medicine framework - p. 375 27. Chapter 20. The cerebellum in Parkinson's disease and levodopa-induced dyskinesia: From neural mechanisms to therapeutic interventions - p. 393 28. Chapter 21. Role of cerebellum in Parkinson's disease symptoms - p. 409 29. Chapter 22. Brainstem origin of Parkinson's disease symptoms - p. 421 30. Index - p. 443
The Handbook of Parkinson’s Disease Mechanisms offers an integrated overview of the fundamental research devoted to understanding its causes and mechanisms, highlighting recent advances and clinical significance. With a strong focus on cellular and animal model studies, this book also examines the etiology, pathophysiology, epidemiology and underlying symptoms of Parkinson’s disease.
Written with an interdisciplinary approach, this book provides thorough research that will be of interest to researchers, clinicians and graduate students interested in neurodegenerative diseases.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Contributors - p. ix 6. Preface - p. xiii 7. Acknowledgments - p. xv 8. Chapter 1. Cross-talk between genetic and environmental factors in Parkinson's disease - p. 1 9. Chapter 2. Neuromelanin: Bridging catecholamine metabolism and neurodegeneration in Parkinson's disease - p. 21 10. Chapter 3. Rodent models for exploring the mechanisms contributing to Parkinson's disease pathophysiology - p. 43 11. Chapter 4. Non-human primate models of Parkinson’s disease and related synucleinopathies - p. 77 12. Chapter 5. Alpha-synuclein spreading in Parkinson's disease - p. 91 13. Chapter 6. The role of mitochondria in the pathogenesis of Parkinson's disease - p. 105 14. Chapter 7. Parkinson's disease: A chronic systemic inflammatory disorder - p. 117 15. Chapter 8. Transcription factor NRF2: New therapeutic approach to modify Parkinson's disease progression - p. 145 16. Chapter 9. Dopamine neurotransmission in Parkinson's disease - p. 171 17. Chapter 10. Morphological plasticity of striatal medium spiny neurons: Its potential contribution to Parkinson's disease pathophysiology - p. 191 18. Chapter 11. Network determinants of motor disability in Parkinson's disease - p. 217 19. Chapter 12. Molecular mechanisms of l-DOPA-induced dyskinesia - p. 235 20. Chapter 13. Cholinergic contributions to Parkinsonian symptoms and l-DOPA-induced dyskinesia - p. 251 21. Chapter 14. Role of the raphe-serotonin system in Parkinson's disease: Compensatory versus maladaptive plasticity - p. 287 22. Chapter 15. Two-factor model of l-DOPA-induced dyskinesia: Bridging early clinical findings with modern mechanistic understanding - p. 299 23. Chapter 16. Network dynamics in rodent models of Parkinson’s disease - p. 321 24. Chapter 17. Reevaluating the role of the STN-GPe network in generating beta synchronized oscillatory activity in parkinsonism - p. 343 25. Chapter 18. Network dynamics in Parkinson's disease: Primate models and patients - p. 357 26. Chapter 19. Cell replacement and gene therapies for Parkinson's disease: A precision medicine framework - p. 375 27. Chapter 20. The cerebellum in Parkinson's disease and levodopa-induced dyskinesia: From neural mechanisms to therapeutic interventions - p. 393 28. Chapter 21. Role of cerebellum in Parkinson's disease symptoms - p. 409 29. Chapter 22. Brainstem origin of Parkinson's disease symptoms - p. 421 30. Index - p. 443
