History of Risk Assessment in Toxicology guides the reader through the historical narrative of the evolution of risk assessment thinking in human and environmental practices. Risk assessment concepts are used in many different professional practice areas. In the health and environmental practices of risk assessment, the critical issue is often what chemical concentration in air, water, food, or a solid substance is acceptable, or considered not to result in any adverse effect.
The book reviews examples from early scientific and health studies to showcase the foundations of risk assessment. The book also explores the development of risk assessment as practiced by major regulatory bodies such as the US Food and Drug Administration (FDA), the Occupational Safety & Health Administration (OSHA), and the US Environmental Protection Agency (EPA) to reveal how risk assessment has evolved in the 20th and 21st centuries.
Modern technology has created opportunities in silicon in vitro, computational modeling, omics, and big data techniques to assess the toxicity of chemicals, while traditional approaches to risk assessment are being challenged with new and innovative approaches. Finally, current issues being debated and tested in risk assessment are outlined with possible future avenues suggested.
1. Series Introduction - p. xiii 2. Chapter 1. Prehistory of Risk Assessment: Origins of Human Tragedies and Concepts of Risk - p. 1 3. Chapter 2. Risk Assessment in the 20th Century Part I: Early Lessons in Food and Drug Safety - p. 5 4. Chapter 3. History of European and Global Regulation of Risk Assessment - p. 17 5. Chapter 4. The History of Risk Assessment Within OSHA and ACGIH: Asbestos Case Study - p. 27 6. Chapter 5. Risk Assessment in the 21st Century: New Technologies and Techniques - p. 32
History of Risk Assessment in Toxicology guides the reader through the historical narrative of the evolution of risk assessment thinking in human and environmental practices. Risk assessment concepts are used in many different professional practice areas. In the health and environmental practices of risk assessment, the critical issue is often what chemical concentration in air, water, food, or a solid substance is acceptable, or considered not to result in any adverse effect.
The book reviews examples from early scientific and health studies to showcase the foundations of risk assessment. The book also explores the development of risk assessment as practiced by major regulatory bodies such as the US Food and Drug Administration (FDA), the Occupational Safety & Health Administration (OSHA), and the US Environmental Protection Agency (EPA) to reveal how risk assessment has evolved in the 20th and 21st centuries.
Modern technology has created opportunities in silicon in vitro, computational modeling, omics, and big data techniques to assess the toxicity of chemicals, while traditional approaches to risk assessment are being challenged with new and innovative approaches. Finally, current issues being debated and tested in risk assessment are outlined with possible future avenues suggested.
1. Series Introduction - p. xiii 2. Chapter 1. Prehistory of Risk Assessment: Origins of Human Tragedies and Concepts of Risk - p. 1 3. Chapter 2. Risk Assessment in the 20th Century Part I: Early Lessons in Food and Drug Safety - p. 5 4. Chapter 3. History of European and Global Regulation of Risk Assessment - p. 17 5. Chapter 4. The History of Risk Assessment Within OSHA and ACGIH: Asbestos Case Study - p. 27 6. Chapter 5. Risk Assessment in the 21st Century: New Technologies and Techniques - p. 32
