The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, Placebo and Pain enhances readers’ knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain.
Review for Placebo and Pain: “This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date [work] on placebo and pain dealing with current perspectives and future challenging issues.--Ted Kaptchuk, Associate Professor of Medicine, Harvard Medical School
1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. Preface - p. Cover 6. Contributors - p. Cover 7. Chapter 1. Historical Aspects of Placebo Analgesia - p. Cover 8. Chapter 2. Neurochemistry of Placebo Analgesia: Opioids, Cannabinoids and Cholecystokinin - p. G7 9. Chapter 3. Placebo Analgesia in Rodents - p. G13 10. Chapter 4. Molecular Mechanisms of Placebo Responses in Humans - p. G22 11. Chapter 5. How does EEG Contribute to Our Understanding of the Placebo Response?: Insights from the Perspective of Bayesian Inference - p. G35 12. Chapter 6. Spinal Mechanisms of Placebo Analgesia and Nocebo Hyperalgesia: Descending Inhibitory and Facilitatory Influences - p. G42 13. Chapter 7. Spinal and Supraspinal Mechanisms of Placebo Analgesia - p. G51 14. Chapter 8. Positive and Negative Emotions and Placebo Analgesia - p. G65 15. Chapter 9. Placing Placebo in Normal Brain Function with Neuroimaging - p. G80 16. Chapter 10. Brain Predictors of Individual Differences in Placebo Responding - p. G88 17. Chapter 11. Placebo Responses, Antagonistic Responses, and Homeostasis - p. G101 18. Chapter 12. Placebo Analgesia, Nocebo Hyperalgesia, and Acupuncture - p. G112 19. Chapter 13. The Relevance of Placebo and Nocebo Mechanisms for Analgesic Treatments - p. G124 20. Chapter 14. How Placebo Responses are Formed: From Bench to Bedside - p. G135 21. Chapter 15. Methodologic Aspects of Placebo Research - p. G146 22. Chapter 16. Balanced Placebo Design, Active Placebos, and Other Design Features for Identifying, Minimizing and Characterizing the Placebo Response - p. G156 23. Chapter 17. Psychological Processes that can Bias Responses to Placebo Treatment for Pain - p. G170 24. Chapter 18. Against ‘Placebo.’ The Case for Changing our Language, and for the Meaning Response - p. G182 25. Chapter 19. Placebo Effects in Complementary and Alternative Medicine: The Self-Healing Response - p. G187 26. Chapter 20. Conceptualizations and Magnitudes of Placebo Analgesia Effects Across Meta-Analyses and Experimental Studies - p. G199 27. Chapter 21. The Contribution of Desire, Expectation, and Reduced Negative Emotions to Placebo Anti-Hyperalgesia in Irritable Bowel Syndrome - p. G211 28. Chapter 22. The Wound that Heals: Placebo, Pain and Surgery - p. G225 29. Chapter 23. What are the Best Placebo Interventions for the Treatment of Pain? - p. G232 30. Chapter 24. How Communication between Clinicians and Patients may Impact Pain Perception - p. G241 31. Chapter 25. Nocebos in Daily Clinical Practice: The Potential Side Effects of the Treatment Context and the Patient–Doctor Interaction on Pain in Clinical Populations - p. G254 32. Chapter 26. The Potential of the Analgesic Placebo Effect in Clinical Practice – Recommendations for Pain Management - p. G265 33. Chapter 27. Placebo and Nocebo: Ethical Challenges and Solutions - p. G275 34. Index - p. G284 35. Color Plates - p. G284
The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, Placebo and Pain enhances readers’ knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain.
Review for Placebo and Pain: “This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date [work] on placebo and pain dealing with current perspectives and future challenging issues.--Ted Kaptchuk, Associate Professor of Medicine, Harvard Medical School
1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. Preface - p. Cover 6. Contributors - p. Cover 7. Chapter 1. Historical Aspects of Placebo Analgesia - p. Cover 8. Chapter 2. Neurochemistry of Placebo Analgesia: Opioids, Cannabinoids and Cholecystokinin - p. G7 9. Chapter 3. Placebo Analgesia in Rodents - p. G13 10. Chapter 4. Molecular Mechanisms of Placebo Responses in Humans - p. G22 11. Chapter 5. How does EEG Contribute to Our Understanding of the Placebo Response?: Insights from the Perspective of Bayesian Inference - p. G35 12. Chapter 6. Spinal Mechanisms of Placebo Analgesia and Nocebo Hyperalgesia: Descending Inhibitory and Facilitatory Influences - p. G42 13. Chapter 7. Spinal and Supraspinal Mechanisms of Placebo Analgesia - p. G51 14. Chapter 8. Positive and Negative Emotions and Placebo Analgesia - p. G65 15. Chapter 9. Placing Placebo in Normal Brain Function with Neuroimaging - p. G80 16. Chapter 10. Brain Predictors of Individual Differences in Placebo Responding - p. G88 17. Chapter 11. Placebo Responses, Antagonistic Responses, and Homeostasis - p. G101 18. Chapter 12. Placebo Analgesia, Nocebo Hyperalgesia, and Acupuncture - p. G112 19. Chapter 13. The Relevance of Placebo and Nocebo Mechanisms for Analgesic Treatments - p. G124 20. Chapter 14. How Placebo Responses are Formed: From Bench to Bedside - p. G135 21. Chapter 15. Methodologic Aspects of Placebo Research - p. G146 22. Chapter 16. Balanced Placebo Design, Active Placebos, and Other Design Features for Identifying, Minimizing and Characterizing the Placebo Response - p. G156 23. Chapter 17. Psychological Processes that can Bias Responses to Placebo Treatment for Pain - p. G170 24. Chapter 18. Against ‘Placebo.’ The Case for Changing our Language, and for the Meaning Response - p. G182 25. Chapter 19. Placebo Effects in Complementary and Alternative Medicine: The Self-Healing Response - p. G187 26. Chapter 20. Conceptualizations and Magnitudes of Placebo Analgesia Effects Across Meta-Analyses and Experimental Studies - p. G199 27. Chapter 21. The Contribution of Desire, Expectation, and Reduced Negative Emotions to Placebo Anti-Hyperalgesia in Irritable Bowel Syndrome - p. G211 28. Chapter 22. The Wound that Heals: Placebo, Pain and Surgery - p. G225 29. Chapter 23. What are the Best Placebo Interventions for the Treatment of Pain? - p. G232 30. Chapter 24. How Communication between Clinicians and Patients may Impact Pain Perception - p. G241 31. Chapter 25. Nocebos in Daily Clinical Practice: The Potential Side Effects of the Treatment Context and the Patient–Doctor Interaction on Pain in Clinical Populations - p. G254 32. Chapter 26. The Potential of the Analgesic Placebo Effect in Clinical Practice – Recommendations for Pain Management - p. G265 33. Chapter 27. Placebo and Nocebo: Ethical Challenges and Solutions - p. G275 34. Index - p. G284 35. Color Plates - p. G284
