Recent Advances in Hemodynamics and Blood Mimetics is a comprehensive compilation of recent developments in biofluid mechanics and biomimetics, covering topics such as numerical modeling, biomedical applications of microfluidics, biomimetic flows, biomedicine applications, and organ-on-chip technology. The book explores blood hemodynamics at different scales, including application to diseases, the relationship between blood biomechanics and rheology, the mimetization of blood properties at arterial and capillary level, including the study of blood mechanical and flow properties, flow and surface properties of blood cells, and mimetization of these same properties in fluid/particle systems.
These concepts are applied to the development of organ-on-chip to improve the replication of biological processes in the human body. The book organizes recent knowledge on hemodynamics and blood mimetics and is representative of the different lines of research in the field, showing an integrated view of blood biomechanics encompassing all scales to create a valuable resource where different research lines can be found and their principles understood.
1. Introduction to biofluids and biomimetics - p. xxvii 2. Section I Numerical methods - p. 1 3. Chapter 1 Patient specific hemodynamics - p. 3 4. Chapter 2 A magnesium stent manufactured by microcasting: Insights from finite element analysis and computational fluid dynamics - p. 21 5. Chapter 3 Two-phase flows (Euler–Euler methods and Euler–Lagrange methods) - p. 55 6. Chapter 4 Macroscopic rheological properties estimated from microstructure of particle suspension - p. 83 7. Chapter 5 Cell cluster modeling in hemodynamics - p. 109 8. Chapter 6 Flow in microfluidic channels: A Smoothed Particle Hydrodynamics (SPH) simulation study - p. 129 9. Section II Biomechanics and hemodynamics - p. 143 10. Chapter 7 Multiscale modeling of biomechanical properties of red blood cells - p. 145 11. Chapter 8 Mechanical characterization of blood cells: Microfluidics technology - p. 165 12. Chapter 9 In Vitro hemodynamics - p. 191 13. Section III Biomimetics, bioinspired and natural flows - p. 205 14. Chapter 10 Taylor dispersion in complex flow fields - p. 207 15. Chapter 11 From water to land: The evolutionary journey of the amphibian heart - p. 219 16. Chapter 12 Applications and properties of PDMS: From biomicrofluidics to transparent face masks - p. 243 17. Chapter 13 Techniques to fabricate microparticles for hemodynamic applications - p. 259 18. Chapter 14 Review on blood analogue fluids - p. 285 19. Chapter 15 Droplet impact of a rheologically-relevant blood simulant at body temperature - p. 301 20. Section IV Applications to biomedicine - p. 311 21. Chapter 16 In Vitro studies of gas embolism - p. 313 22. Chapter 17 Pathological hemodynamics and localized therapeutics - p. 345 23. Chapter 18 Flow visualizations in polydimethylsiloxane cerebral aneurysm biomodels - p. 361 24. Chapter 19 Image-based blood flow simulation in the left atrium: Recent progress and future perspectives - p. 369 25. Section V Applications to organs-on-chip - p. 383 26. Chapter 20 Polydimethylsiloxane surface modification for microfluidic devices and organ-on-chip platforms - p. 385 27. Chapter 21 Flow assessment and analysis of oxygen transport in an organ-on-chip platform - p. 397 28. Chapter 22 Polydimethylsiloxane microneedles for organ-on-chip platforms - p. 409 29. Index - p. 425
Recent Advances in Hemodynamics and Blood Mimetics is a comprehensive compilation of recent developments in biofluid mechanics and biomimetics, covering topics such as numerical modeling, biomedical applications of microfluidics, biomimetic flows, biomedicine applications, and organ-on-chip technology. The book explores blood hemodynamics at different scales, including application to diseases, the relationship between blood biomechanics and rheology, the mimetization of blood properties at arterial and capillary level, including the study of blood mechanical and flow properties, flow and surface properties of blood cells, and mimetization of these same properties in fluid/particle systems.
These concepts are applied to the development of organ-on-chip to improve the replication of biological processes in the human body. The book organizes recent knowledge on hemodynamics and blood mimetics and is representative of the different lines of research in the field, showing an integrated view of blood biomechanics encompassing all scales to create a valuable resource where different research lines can be found and their principles understood.
1. Introduction to biofluids and biomimetics - p. xxvii 2. Section I Numerical methods - p. 1 3. Chapter 1 Patient specific hemodynamics - p. 3 4. Chapter 2 A magnesium stent manufactured by microcasting: Insights from finite element analysis and computational fluid dynamics - p. 21 5. Chapter 3 Two-phase flows (Euler–Euler methods and Euler–Lagrange methods) - p. 55 6. Chapter 4 Macroscopic rheological properties estimated from microstructure of particle suspension - p. 83 7. Chapter 5 Cell cluster modeling in hemodynamics - p. 109 8. Chapter 6 Flow in microfluidic channels: A Smoothed Particle Hydrodynamics (SPH) simulation study - p. 129 9. Section II Biomechanics and hemodynamics - p. 143 10. Chapter 7 Multiscale modeling of biomechanical properties of red blood cells - p. 145 11. Chapter 8 Mechanical characterization of blood cells: Microfluidics technology - p. 165 12. Chapter 9 In Vitro hemodynamics - p. 191 13. Section III Biomimetics, bioinspired and natural flows - p. 205 14. Chapter 10 Taylor dispersion in complex flow fields - p. 207 15. Chapter 11 From water to land: The evolutionary journey of the amphibian heart - p. 219 16. Chapter 12 Applications and properties of PDMS: From biomicrofluidics to transparent face masks - p. 243 17. Chapter 13 Techniques to fabricate microparticles for hemodynamic applications - p. 259 18. Chapter 14 Review on blood analogue fluids - p. 285 19. Chapter 15 Droplet impact of a rheologically-relevant blood simulant at body temperature - p. 301 20. Section IV Applications to biomedicine - p. 311 21. Chapter 16 In Vitro studies of gas embolism - p. 313 22. Chapter 17 Pathological hemodynamics and localized therapeutics - p. 345 23. Chapter 18 Flow visualizations in polydimethylsiloxane cerebral aneurysm biomodels - p. 361 24. Chapter 19 Image-based blood flow simulation in the left atrium: Recent progress and future perspectives - p. 369 25. Section V Applications to organs-on-chip - p. 383 26. Chapter 20 Polydimethylsiloxane surface modification for microfluidic devices and organ-on-chip platforms - p. 385 27. Chapter 21 Flow assessment and analysis of oxygen transport in an organ-on-chip platform - p. 397 28. Chapter 22 Polydimethylsiloxane microneedles for organ-on-chip platforms - p. 409 29. Index - p. 425
