Biology of Mycobacterial Lipids covers various topics pertaining to the advancements and current research in the field of mycobacterial lipids, and on the significant progress in lipidomics, in recent times. The chapters present comprehensive, yet systematic cutting-edge research, comprising mycobacterial lipid terminologies, classifications, biosynthetic pathways, tools and techniques, and functional burgeoning. This unique reference book has contributions from pioneer researchers, experts, and eminent veterans from around the globe. It covers ground-breaking work that will bridge the gap between understanding biochemical patterns related to virulence, pathogenesis, and resistance and elucidating new targets for drug design, identifying biomarkers for predicting risk, early diagnosis, and therapeutic outcome.
1. Biology of Mycobacterial Lipids - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Tribute for Professor David E. Minnikin, MA, DPhil, DSc (1939–2021) - p. Page iv 7. List of contributors - p. Page v 8. Foreword - p. Page viii 9. Preface - p. Page viii 10. List of Illustrations - p. Page x 11. List of Tables - p. Page xi 12. Chapter 1 : An overview of mycolic acids: structure–function–classification, biosynthesis, and beyond - p. Page xi 13. Chapter 2 : Lipid biosynthetic pathways as potential drug targets for emerging mycobacterial pathogens - p. Page 20 14. Chapter 3 : Mycobacterial lipids in the host–pathogen interface: roles in pathogenesis and host immune response - p. Page 44 15. Chapter 4 : Lipids and glycolipids as biomarkers of mycobacterial infections - p. Page 74 16. Chapter 5 : Multifaceted roles of mycobacterium cell envelope glycolipids during host cell membrane interactions - p. Page 99 17. Chapter 6 : Conserved mechanisms drive host-lipid access, import, and utilization in Mycobacterium tuberculosis and M. marinum - p. Page 124 18. Chapter 7 : Biological implications of mycobacterial lipids on NKT-cells stimulation - p. Page 154 19. Chapter 8 : The effect of chemically synthetic mycobacterial mycolates on phospholipidome immunomodulation of murine macrophages - p. Page 176 20. Chapter 9 : Polyketide synthases in mycobacterial lipid metabolism - p. Page 202 21. Chapter 10 : Understanding mycobacterial lipid metabolism and employing it as a tool to produce attenuated TB vaccine candidates - p. Page 216 22. Chapter 11 : Deciphering the physiological role of serine enzymes involved in mycobacterial lipid metabolism using activity-based protein profiling - p. Page 229 23. Chapter 12 : Intrabacterial lipid inclusions: overview of an amazing organelle - p. Page 248 24. Chapter 13 : Multiple facets and functions of the toxin mycolactone produced by Mycobacterium ulcerans - p. Page 266 25. Index - p. Page 285
Biology of Mycobacterial Lipids covers various topics pertaining to the advancements and current research in the field of mycobacterial lipids, and on the significant progress in lipidomics, in recent times. The chapters present comprehensive, yet systematic cutting-edge research, comprising mycobacterial lipid terminologies, classifications, biosynthetic pathways, tools and techniques, and functional burgeoning. This unique reference book has contributions from pioneer researchers, experts, and eminent veterans from around the globe. It covers ground-breaking work that will bridge the gap between understanding biochemical patterns related to virulence, pathogenesis, and resistance and elucidating new targets for drug design, identifying biomarkers for predicting risk, early diagnosis, and therapeutic outcome.
1. Biology of Mycobacterial Lipids - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Tribute for Professor David E. Minnikin, MA, DPhil, DSc (1939–2021) - p. Page iv 7. List of contributors - p. Page v 8. Foreword - p. Page viii 9. Preface - p. Page viii 10. List of Illustrations - p. Page x 11. List of Tables - p. Page xi 12. Chapter 1 : An overview of mycolic acids: structure–function–classification, biosynthesis, and beyond - p. Page xi 13. Chapter 2 : Lipid biosynthetic pathways as potential drug targets for emerging mycobacterial pathogens - p. Page 20 14. Chapter 3 : Mycobacterial lipids in the host–pathogen interface: roles in pathogenesis and host immune response - p. Page 44 15. Chapter 4 : Lipids and glycolipids as biomarkers of mycobacterial infections - p. Page 74 16. Chapter 5 : Multifaceted roles of mycobacterium cell envelope glycolipids during host cell membrane interactions - p. Page 99 17. Chapter 6 : Conserved mechanisms drive host-lipid access, import, and utilization in Mycobacterium tuberculosis and M. marinum - p. Page 124 18. Chapter 7 : Biological implications of mycobacterial lipids on NKT-cells stimulation - p. Page 154 19. Chapter 8 : The effect of chemically synthetic mycobacterial mycolates on phospholipidome immunomodulation of murine macrophages - p. Page 176 20. Chapter 9 : Polyketide synthases in mycobacterial lipid metabolism - p. Page 202 21. Chapter 10 : Understanding mycobacterial lipid metabolism and employing it as a tool to produce attenuated TB vaccine candidates - p. Page 216 22. Chapter 11 : Deciphering the physiological role of serine enzymes involved in mycobacterial lipid metabolism using activity-based protein profiling - p. Page 229 23. Chapter 12 : Intrabacterial lipid inclusions: overview of an amazing organelle - p. Page 248 24. Chapter 13 : Multiple facets and functions of the toxin mycolactone produced by Mycobacterium ulcerans - p. Page 266 25. Index - p. Page 285
