The Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy. This second edition of Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers a thorough, timely discussion of ethical issues raised by the latest genetic and genomic technologies applied in human reproductive and prenatal medicine, providing practical recommendations, guidelines, and algorithms to support ethical clinical practice. Here, international experts consider the ethics of technologies from preconception carrier screening to genetic engineering, CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction, and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Throughout the book, contributors adopt a global, holistic perspective on applied challenges and the moral questions around the implementation of genetic reproductive technologies. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors, and graduate and medical students.This fully updated second edition examines new developments in the field, tackling ethical aspects of organoid development, recent advances in pharmacogenomics, direct-to-consumer genetic testing, and genetic engineering.
1. Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. Contributors - p. Page v 7. List of Illustrations - p. Page viii 8. List of Tables - p. Page ix 9. Chapter 1 : Genomic editing: From human health to the “perfect child” - p. Page ix 10. Chapter 2 : Ethics of mitochondrial gene replacement therapy - p. Page 28 11. Chapter 3 : Reproductive technologies used by same-gender couples - p. Page 51 12. Chapter 4 : Ethical issues raised by multiparents - p. Page 75 13. Chapter 5 : Revisiting the nondirective principle of genetic counseling in prenatal screening - p. Page 97 14. Chapter 6 : Sex selection, gender selection, and sexism - p. Page 114 15. Chapter 7 : The impact of “Big Data” on beginning-of-life issues - p. Page 132 16. Chapter 8 : The moral status of the embryo and its uses: Bioethics and social perceptions - p. Page 146 17. Chapter 9 : Fetal reduction - p. Page 199 18. Chapter 10 : Stem cell therapies for neurodegenerative disorders: An ethical analysis - p. Page 214 19. Chapter 11 : Predictive genetic testing in multifactorial disorders - p. Page 233 20. Chapter 12 : Whole-genome sequencing as a method of prenatal genetic diagnosis: Ethical issues - p. Page 267 21. Chapter 13 : Noninvasive prenatal genetic diagnosis - p. Page 296 22. Chapter 14 : Prenatal testing in low-risk populations: After routinization - p. Page 321 23. Chapter 15 : Using genetics for enhancement (liberal eugenics) - p. Page 342 24. Chapter 16 : Should incidental findings arising from prenatal testing be reported indiscriminately to patients? - p. Page 373 25. Chapter 17 : Third-party sharing of genetic information - p. Page 396 26. Chapter 18 : Cerebral and noncerebral organoids - p. Page 425 27. Chapter 19 : Cognitive enhancement: Bioethical aspects - p. Page 446 28. Chapter 20 : Risks and benefits of direct-to-consumer genetic testing in the reproductive context - p. Page 458 29. Chapter 21 : Genetic immunization: Enhancement or public health measure? - p. Page 494 30. Index - p. Page 524
The Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy. This second edition of Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers a thorough, timely discussion of ethical issues raised by the latest genetic and genomic technologies applied in human reproductive and prenatal medicine, providing practical recommendations, guidelines, and algorithms to support ethical clinical practice. Here, international experts consider the ethics of technologies from preconception carrier screening to genetic engineering, CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction, and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Throughout the book, contributors adopt a global, holistic perspective on applied challenges and the moral questions around the implementation of genetic reproductive technologies. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors, and graduate and medical students.This fully updated second edition examines new developments in the field, tackling ethical aspects of organoid development, recent advances in pharmacogenomics, direct-to-consumer genetic testing, and genetic engineering.
1. Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. Contributors - p. Page v 7. List of Illustrations - p. Page viii 8. List of Tables - p. Page ix 9. Chapter 1 : Genomic editing: From human health to the “perfect child” - p. Page ix 10. Chapter 2 : Ethics of mitochondrial gene replacement therapy - p. Page 28 11. Chapter 3 : Reproductive technologies used by same-gender couples - p. Page 51 12. Chapter 4 : Ethical issues raised by multiparents - p. Page 75 13. Chapter 5 : Revisiting the nondirective principle of genetic counseling in prenatal screening - p. Page 97 14. Chapter 6 : Sex selection, gender selection, and sexism - p. Page 114 15. Chapter 7 : The impact of “Big Data” on beginning-of-life issues - p. Page 132 16. Chapter 8 : The moral status of the embryo and its uses: Bioethics and social perceptions - p. Page 146 17. Chapter 9 : Fetal reduction - p. Page 199 18. Chapter 10 : Stem cell therapies for neurodegenerative disorders: An ethical analysis - p. Page 214 19. Chapter 11 : Predictive genetic testing in multifactorial disorders - p. Page 233 20. Chapter 12 : Whole-genome sequencing as a method of prenatal genetic diagnosis: Ethical issues - p. Page 267 21. Chapter 13 : Noninvasive prenatal genetic diagnosis - p. Page 296 22. Chapter 14 : Prenatal testing in low-risk populations: After routinization - p. Page 321 23. Chapter 15 : Using genetics for enhancement (liberal eugenics) - p. Page 342 24. Chapter 16 : Should incidental findings arising from prenatal testing be reported indiscriminately to patients? - p. Page 373 25. Chapter 17 : Third-party sharing of genetic information - p. Page 396 26. Chapter 18 : Cerebral and noncerebral organoids - p. Page 425 27. Chapter 19 : Cognitive enhancement: Bioethical aspects - p. Page 446 28. Chapter 20 : Risks and benefits of direct-to-consumer genetic testing in the reproductive context - p. Page 458 29. Chapter 21 : Genetic immunization: Enhancement or public health measure? - p. Page 494 30. Index - p. Page 524
