Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. List of figures - p. Cover 6. List of abbreviations - p. Cover 7. About the authors - p. Cover 8. Preface - p. Cover 9. Chapter 1: MHC and T cell responses - p. Cover 10. Chapter 2: Immunoglobulins and B cell responses - p. 12 11. Chapter 3: Scientific publications and databases - p. 20 12. Chapter 4: Database design - p. 46 13. Chapter 5: Computational T cell vaccine design - p. 57 14. Chapter 6: Computational B cell vaccine design - p. 86 15. Chapter 7: Infectious disease informatics - p. 97 16. Chapter 8: Vaccine safety and quality assessments - p. 109 17. Chapter 9: Vaccine adjuvant informatics - p. 121 18. Index - p. 129
Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates.
Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics.
1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. List of figures - p. Cover 6. List of abbreviations - p. Cover 7. About the authors - p. Cover 8. Preface - p. Cover 9. Chapter 1: MHC and T cell responses - p. Cover 10. Chapter 2: Immunoglobulins and B cell responses - p. 12 11. Chapter 3: Scientific publications and databases - p. 20 12. Chapter 4: Database design - p. 46 13. Chapter 5: Computational T cell vaccine design - p. 57 14. Chapter 6: Computational B cell vaccine design - p. 86 15. Chapter 7: Infectious disease informatics - p. 97 16. Chapter 8: Vaccine safety and quality assessments - p. 109 17. Chapter 9: Vaccine adjuvant informatics - p. 121 18. Index - p. 129
