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Dr. Reuben provides a timely update to the topic of HCC, which was last covered in 2011. The highly respected authors in his issue address advances in imaging for diagnosis, surgical resection and liver transplantation, and local and systemic therapy. The breadth of the topic is covered, with articles devoted to histopathology, classification and staging, and screening and detection.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright Page - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 8 7. Hepatocellular Carcinoma in Adults and Children - p. 9 8. Global Epidemiology of Hepatocellular Carcinoma - p. 11 9. Anatomic Pathology of Hepatocellular Carcinoma - p. 17 10. Pathogenesis and Prognosis of Hepatocellular Carcinoma at the Cellular and Molecular Levels - p. 25 11. Classification and Staging of Hepatocellular Carcinoma - p. 32 12. Screening and Detection of Hepatocellular Carcinoma - p. 41 13. Elevated Alpha-Fetoprotein - p. 48 14. Imaging of Hepatocellular Carcinoma - p. 56 15. Oncogenic Viruses and Hepatocellular Carcinoma - p. 63 16. Nonalcoholic Fatty Liver Disease, Diabetes, Obesity, and Hepatocellular Carcinoma - p. 75 17. Surgical Resection and Liver Transplantation for Hepatocellular Carcinoma - p. 87 18. Locoregional Therapy of Hepatocellular Carcinoma - p. 96 19. Systemic Therapy of Hepatocellular Carcinoma - p. 107 20. Hepatocellular Carcinoma in Children - p. 115

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Dr. Reuben provides a timely update to the topic of HCC, which was last covered in 2011. The highly respected authors in his issue address advances in imaging for diagnosis, surgical resection and liver transplantation, and local and systemic therapy. The breadth of the topic is covered, with articles devoted to histopathology, classification and staging, and screening and detection.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright Page - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 8 7. Hepatocellular Carcinoma in Adults and Children - p. 9 8. Global Epidemiology of Hepatocellular Carcinoma - p. 11 9. Anatomic Pathology of Hepatocellular Carcinoma - p. 17 10. Pathogenesis and Prognosis of Hepatocellular Carcinoma at the Cellular and Molecular Levels - p. 25 11. Classification and Staging of Hepatocellular Carcinoma - p. 32 12. Screening and Detection of Hepatocellular Carcinoma - p. 41 13. Elevated Alpha-Fetoprotein - p. 48 14. Imaging of Hepatocellular Carcinoma - p. 56 15. Oncogenic Viruses and Hepatocellular Carcinoma - p. 63 16. Nonalcoholic Fatty Liver Disease, Diabetes, Obesity, and Hepatocellular Carcinoma - p. 75 17. Surgical Resection and Liver Transplantation for Hepatocellular Carcinoma - p. 87 18. Locoregional Therapy of Hepatocellular Carcinoma - p. 96 19. Systemic Therapy of Hepatocellular Carcinoma - p. 107 20. Hepatocellular Carcinoma in Children - p. 115

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