In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing.
Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xi 6. Editors Biographies - p. xiii 7. Foreword - p. xv 8. Preface - p. xvii 9. Acknowledgments - p. xix 10. Chapter 1. Development of In Vitro Toxicology: A Historic Story - p. 1 11. Chapter 2. Principles for In Vitro Toxicology - p. 21 12. Chapter 3. Models and Methods for In Vitro Toxicity - p. 45 13. Chapter 4. In Vitro Gene Genotoxicity Test Methods - p. 67 14. Chapter 5. In Silico Approaches for Predictive Toxicology - p. 91 15. Chapter 6. The Use of Transcriptional Profiling in In Vitro Systems to Determine the Potential Estrogenic Activity of Chemicals of Interest - p. 111 16. Chapter 7. Extrapolation of In Vitro Results to Predict Human Toxicity - p. 127 17. Chapter 8. Role of Molecular Chaperone Network in Understanding In Vitro Proteotoxicity - p. 143 18. Chapter 9. Scientific and Regulatory Considerations in the Development of in Vitro Techniques for Toxicology - p. 165 19. Chapter 10. Safety Concerns Using Cell-Based In Vitro Methods for Toxicity Assessment - p. 187 20. Chapter 11. In Vitro Methods for Predicting Ocular Irritation - p. 209 21. Index - p. 221
In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing.
Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xi 6. Editors Biographies - p. xiii 7. Foreword - p. xv 8. Preface - p. xvii 9. Acknowledgments - p. xix 10. Chapter 1. Development of In Vitro Toxicology: A Historic Story - p. 1 11. Chapter 2. Principles for In Vitro Toxicology - p. 21 12. Chapter 3. Models and Methods for In Vitro Toxicity - p. 45 13. Chapter 4. In Vitro Gene Genotoxicity Test Methods - p. 67 14. Chapter 5. In Silico Approaches for Predictive Toxicology - p. 91 15. Chapter 6. The Use of Transcriptional Profiling in In Vitro Systems to Determine the Potential Estrogenic Activity of Chemicals of Interest - p. 111 16. Chapter 7. Extrapolation of In Vitro Results to Predict Human Toxicity - p. 127 17. Chapter 8. Role of Molecular Chaperone Network in Understanding In Vitro Proteotoxicity - p. 143 18. Chapter 9. Scientific and Regulatory Considerations in the Development of in Vitro Techniques for Toxicology - p. 165 19. Chapter 10. Safety Concerns Using Cell-Based In Vitro Methods for Toxicity Assessment - p. 187 20. Chapter 11. In Vitro Methods for Predicting Ocular Irritation - p. 209 21. Index - p. 221
