This issue of Hematology/Oncology Clinics is guest edited by Dr. Christoph Klein and focuses on the topic of Neutropenia. Article titles include: Homeostasis and migration of neutrophil granulocytes,Granulocyte-colony Stimulating Factor (G-CSF) receptor signaling,New Granulocyte-colony Stimulating Factor (G-CSF) Receptor Signaling Pathways ,Neutrophil elastase (ELANE) – Genetics and Pathophysiology,Autosomal recessive variants of Severe congenital neutropenia (SCN),Leukocyte Adhesion Deficiency (LAD), and Genotype-phenotype correlations in Severe congenital neutropenia (SCN).
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 5 6. Preface - p. 6 7. Epidemiology of Congenital Neutropenia - p. 7 8. ELANE Mutations in Cyclic and Severe Congenital Neutropenia - p. 15 9. Genetics and Pathophysiology of Severe Congenital Neutropenia Syndromes Unrelated to Neutrophil Elastase - p. 26 10. Granulocyte Colony-Stimulating Factor Receptor Signaling - p. 36 11. Defective G-CSFR Signaling Pathways in Congenital Neutropenia - p. 44 12. Chronic Granulomatous Disease - p. 52 13. Leukocyte Adhesion Deficiencies - p. 59 14. Clinical and Molecular Pathophysiology of Shwachman–Diamond Syndrome - p. 67 15. Animal Models of Human Granulocyte Diseases - p. 74 16. Index - p. 84
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This issue of Hematology/Oncology Clinics is guest edited by Dr. Christoph Klein and focuses on the topic of Neutropenia. Article titles include: Homeostasis and migration of neutrophil granulocytes,Granulocyte-colony Stimulating Factor (G-CSF) receptor signaling,New Granulocyte-colony Stimulating Factor (G-CSF) Receptor Signaling Pathways ,Neutrophil elastase (ELANE) – Genetics and Pathophysiology,Autosomal recessive variants of Severe congenital neutropenia (SCN),Leukocyte Adhesion Deficiency (LAD), and Genotype-phenotype correlations in Severe congenital neutropenia (SCN).
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 5 6. Preface - p. 6 7. Epidemiology of Congenital Neutropenia - p. 7 8. ELANE Mutations in Cyclic and Severe Congenital Neutropenia - p. 15 9. Genetics and Pathophysiology of Severe Congenital Neutropenia Syndromes Unrelated to Neutrophil Elastase - p. 26 10. Granulocyte Colony-Stimulating Factor Receptor Signaling - p. 36 11. Defective G-CSFR Signaling Pathways in Congenital Neutropenia - p. 44 12. Chronic Granulomatous Disease - p. 52 13. Leukocyte Adhesion Deficiencies - p. 59 14. Clinical and Molecular Pathophysiology of Shwachman–Diamond Syndrome - p. 67 15. Animal Models of Human Granulocyte Diseases - p. 74 16. Index - p. 84
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