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Dr. Brown provides a timely upate on the clinical diagnosis and management of Hepatic Encephalopathy. His issue addresses current hot topics including Role of NH4 in Pathogenesis of Hepatic Encephalopathy; How to diagnose and manage HE in fulminant hepatic failure; New methods of Brain Imaging and testing (eg PET) and Hepatic Encephalopathy; Management New agents for HE (focus on NH4 lowering drugs used in UCD); Legal responsibility of MD when he diagnoses HE; Diets in Encephalopathy; and Neurological manifestations of HE.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 8 7. Preface: HE or not HE? That is Frequently the Question - p. 9 8. New Methods of Testing and Brain Imaging in Hepatic Encephalopathy - p. 10 9. Clinical and Neurologic Manifestation of Minimal Hepatic Encephalopathy and Overt Hepatic Encephalopathy - p. 17 10. Covert Hepatic Encephalopathy - p. 22 11. Should We Treat Minimal/Covert Hepatic Encephalopathy, and with What? - p. 29 12. Diets in Encephalopathy - p. 35 13. The Role of Sarcopenia and Frailty in Hepatic Encephalopathy Management - p. 40 14. Ammonia and Its Role in the Pathogenesis of Hepatic Encephalopathy - p. 50 15. Novel Ammonia-Lowering Agents for Hepatic Encephalopathy - p. 54 16. Treatment of Overt Hepatic Encephalopathy - p. 61 17. Diagnosis and Management of Hepatic Encephalopathy in Fulminant Hepatic Failure - p. 68 18. Legal Responsibilities of Physicians When They Diagnose Hepatic Encephalopathy - p. 75

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Dr. Brown provides a timely upate on the clinical diagnosis and management of Hepatic Encephalopathy. His issue addresses current hot topics including Role of NH4 in Pathogenesis of Hepatic Encephalopathy; How to diagnose and manage HE in fulminant hepatic failure; New methods of Brain Imaging and testing (eg PET) and Hepatic Encephalopathy; Management New agents for HE (focus on NH4 lowering drugs used in UCD); Legal responsibility of MD when he diagnoses HE; Diets in Encephalopathy; and Neurological manifestations of HE.

1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Copyright - p. 4 5. Contributors - p. 5 6. Forthcoming Issues - p. 8 7. Preface: HE or not HE? That is Frequently the Question - p. 9 8. New Methods of Testing and Brain Imaging in Hepatic Encephalopathy - p. 10 9. Clinical and Neurologic Manifestation of Minimal Hepatic Encephalopathy and Overt Hepatic Encephalopathy - p. 17 10. Covert Hepatic Encephalopathy - p. 22 11. Should We Treat Minimal/Covert Hepatic Encephalopathy, and with What? - p. 29 12. Diets in Encephalopathy - p. 35 13. The Role of Sarcopenia and Frailty in Hepatic Encephalopathy Management - p. 40 14. Ammonia and Its Role in the Pathogenesis of Hepatic Encephalopathy - p. 50 15. Novel Ammonia-Lowering Agents for Hepatic Encephalopathy - p. 54 16. Treatment of Overt Hepatic Encephalopathy - p. 61 17. Diagnosis and Management of Hepatic Encephalopathy in Fulminant Hepatic Failure - p. 68 18. Legal Responsibilities of Physicians When They Diagnose Hepatic Encephalopathy - p. 75

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