Differential scanning calorimetry (DSC) is the most important thermal analysis technique used today and the most common thermal analysis instrument found in chemical characterization laboratories. DSC has become an everyday tool in characterization laboratories, but many researchers using this technique have a limited understanding of the true breadth of its capabilities. Up to now, there has been no book that would describe the application of DSC in all the various areas of materials chemistry. The Handbook of Differential Scanning Calorimetry has been written to fill that void. This book is designed to summarize the knowledge of differential scanning calorimetry so that materials researchers and application chemists are given both a better understanding of techniques , as well as a review of the full scope of its capabilities. It also discusses how to properly interpret the DSC thermograms data obtained. Included in this work is the most up-to-date information written by some of the leaders in the field. It is written not only to help users get the most out of their equipment, After reading this book, people in all chemical and biological areas will have a broad overview of this measuring technique, and will be able to utilize this analytical technique more efficiently.
1. 1.1 Introduction - p. 4 2. 1.2 Overview of DSC - p. 6 3. 1.3 Elements of Thermodynamics in Differential Scanning Calorimetry - p. 25 4. 1.4 PerkinElmer’s Power Compensation DSC - p. 38 5. 1.5 Heat-Flux DSC - p. 44 6. 1.6 Tian-Calvet Calorimeters - p. 64 7. 1.7 Modulated Temperature DSC - p. 63 8. 1.8 Fast Scanning Calorimetry - p. 78 9. 1.9 Photocalorimetry - p. 80 10. 1.10 High Temperature DSC - p. 98 11. 1.11 Calibration of DSCs - p. 98 12. 1.12 Measurement of Heat Capacity by DSC - p. 116 13. 1.13 Thermal Transitions in DSC - p. 125 14. 1.14 Baseline - p. 156 15. 1.15 Accessories for DSC Measurements - p. 159 16. References - p. 180 17. Further reading - p. 188 18. Chapter 2. The Theory of Modulated Temperature Differential Scanning Calorimetry - p. 191 19. Chapter 3. Chip-Based Fast Scanning Calorimetry - p. 221 20. Chapter 4. DSC of Inorganic Materials - p. 327 21. Abstract - p. 327 22. Symbols and Abbreviations - p. 327 23. 4.1 Introduction - p. 310 24. 4.2 Principles of Application of DSC to Inorganic Compounds and Elements - p. 311 25. 4.3 Experimental Conditions in DSC Measurements - p. 324 26. 4.4 Application of DSC to Elements and Alloys - p. 326 27. 4.5 Application of DSC to Oxides and Sulfides - p. 383 28. 4.6 Application of DSC to Inorganic Salts - p. 412 29. References - p. 477 30. Chapter 5. DSC of Low Molecular Mass Organic Materials and Pharmaceuticals - p. 513 31. Abstract - p. 513 32. Abbreviations - p. 513 33. 5.1 Introduction - p. 489 34. 5.2 Purity Evaluation - p. 494 35. 5.3 Polymorphism - p. 506 36. 5.4 Compatibility of Tablet Ingredients - p. 536 37. 5.5 Chemical Kinetics for Characterization of Thermal Stability and Shelf Life of APIs - p. 568 38. 5.6 Thermal Behavior and Thermal Stability - p. 579 39. 5.7 Thermal and Thermooxidative Degradation - p. 596 40. 5.8 Conclusions - p. 639 41. References - p. 640 42. Chapter 6. Simultaneous DSC Techniques - p. 659 43. Chapter 7. Instrumentation - p. 793 44. Index - p. 841
Differential scanning calorimetry (DSC) is the most important thermal analysis technique used today and the most common thermal analysis instrument found in chemical characterization laboratories. DSC has become an everyday tool in characterization laboratories, but many researchers using this technique have a limited understanding of the true breadth of its capabilities. Up to now, there has been no book that would describe the application of DSC in all the various areas of materials chemistry. The Handbook of Differential Scanning Calorimetry has been written to fill that void. This book is designed to summarize the knowledge of differential scanning calorimetry so that materials researchers and application chemists are given both a better understanding of techniques , as well as a review of the full scope of its capabilities. It also discusses how to properly interpret the DSC thermograms data obtained. Included in this work is the most up-to-date information written by some of the leaders in the field. It is written not only to help users get the most out of their equipment, After reading this book, people in all chemical and biological areas will have a broad overview of this measuring technique, and will be able to utilize this analytical technique more efficiently.
1. 1.1 Introduction - p. 4 2. 1.2 Overview of DSC - p. 6 3. 1.3 Elements of Thermodynamics in Differential Scanning Calorimetry - p. 25 4. 1.4 PerkinElmer’s Power Compensation DSC - p. 38 5. 1.5 Heat-Flux DSC - p. 44 6. 1.6 Tian-Calvet Calorimeters - p. 64 7. 1.7 Modulated Temperature DSC - p. 63 8. 1.8 Fast Scanning Calorimetry - p. 78 9. 1.9 Photocalorimetry - p. 80 10. 1.10 High Temperature DSC - p. 98 11. 1.11 Calibration of DSCs - p. 98 12. 1.12 Measurement of Heat Capacity by DSC - p. 116 13. 1.13 Thermal Transitions in DSC - p. 125 14. 1.14 Baseline - p. 156 15. 1.15 Accessories for DSC Measurements - p. 159 16. References - p. 180 17. Further reading - p. 188 18. Chapter 2. The Theory of Modulated Temperature Differential Scanning Calorimetry - p. 191 19. Chapter 3. Chip-Based Fast Scanning Calorimetry - p. 221 20. Chapter 4. DSC of Inorganic Materials - p. 327 21. Abstract - p. 327 22. Symbols and Abbreviations - p. 327 23. 4.1 Introduction - p. 310 24. 4.2 Principles of Application of DSC to Inorganic Compounds and Elements - p. 311 25. 4.3 Experimental Conditions in DSC Measurements - p. 324 26. 4.4 Application of DSC to Elements and Alloys - p. 326 27. 4.5 Application of DSC to Oxides and Sulfides - p. 383 28. 4.6 Application of DSC to Inorganic Salts - p. 412 29. References - p. 477 30. Chapter 5. DSC of Low Molecular Mass Organic Materials and Pharmaceuticals - p. 513 31. Abstract - p. 513 32. Abbreviations - p. 513 33. 5.1 Introduction - p. 489 34. 5.2 Purity Evaluation - p. 494 35. 5.3 Polymorphism - p. 506 36. 5.4 Compatibility of Tablet Ingredients - p. 536 37. 5.5 Chemical Kinetics for Characterization of Thermal Stability and Shelf Life of APIs - p. 568 38. 5.6 Thermal Behavior and Thermal Stability - p. 579 39. 5.7 Thermal and Thermooxidative Degradation - p. 596 40. 5.8 Conclusions - p. 639 41. References - p. 640 42. Chapter 6. Simultaneous DSC Techniques - p. 659 43. Chapter 7. Instrumentation - p. 793 44. Index - p. 841
