Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome metabolome vagus nerve brain circuit in Alzheimer’s disease and associated diseases and medical conditions, including dementia, aging, COVID-19, autoimmune conditions, and inflammatory skin condition rosacea, which may increase the risk of other conditions. This book also discusses the vagus nerve-related conditions, including Arnold’s reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in the book also address an important question of which one is more important for human health and intellectual abilities: the human genome or the human microbiome? The conceptual model of food and gut microbial tryptamine vagus nerve circuit is also presented in this book.
1. Chapter 1. Introduction: Microbial metabolite interference of protein biosynthesis in neurodegenerative, neurodevelopmental, and other disorders; microbial metabolites hijacking vagus nerve - p. 1 2. Chapter 2. COVID-19: Scientific progress - p. 11 3. Chapter 3. Viral-bacterial interactions in diseases - p. 49 4. Chapter 4. Vagus nerve: Acid reflux, parietal cells, carpal tunnel syndrome, Alzheimer’s disease, COVID-19, stroke, cancer, and other diseases - p. 65 5. Chapter 5. Vagus nerve circuit: Microbiome—tryptophan metabolites—receptors and synapses - p. 83 6. Chapter 6. Glutamate and glutamate receptors in vagus nerve pathways and in Alzheimer’s disease - p. 115 7. Chapter 7. Aminoacyl tRNA synthetase multiple forms in autoimmune and infectious diseases - p. 131 8. Crystalized aromatic L-amino acid decarboxylase from bacteria Micrococcus percitreus catalyzing decarboxylation of tryptophan and L-DOPA (Levodopa or 3,4-dihydroxy-L-phenylalanine) - p. 147 9. Health effects of elevated CO2 levels, sparkling mineral water, seltzer carbonated water - p. 157 10. Chapter 10. Microbial antigens, allergies, and antibodies to microbial allergens: Significance of preexisting antibodies and stress for vaccination - p. 173 11. Chapter 11. Smell and taste identification deficits in disease - p. 187 12. Chapter 12. Microorganisms producing biogenic amines: From food to human body - p. 201 13. Chapter 13. Human genome or human microbiome genes: Which one is more important for human health and intellectual abilities? - p. 207 14. Chapter 14. Microorganisms used in agriculture, consumed from environment and associated with the edible raw fruits, vegetables, herbs, sprouts, and mushrooms - p. 241 15. Chapter 15. Molecular and cell aggregation: Biogenic amines, proteins, platelets, and microbial pathogens - p. 257 16. Chapter 16. Colonic diverticular disease as a risk factor for neurodegenerative and associated diseases - p. 267 17. Chapter 17. Alzheimer’s disease, dementia, aging, and COVID-19 - p. 291 18. Chapter 18. Existing vaccines and new and old tools - p. 309 19. Chapter 19. Serotonin syndrome in neurodegenerative diseases and COVID-19: Mechanisms and consequences of intestinal infection - p. 325 20. Chapter 20. Circulating cell-free mitochondria and membrane vesicles - p. 345 21. Chapter 21. Protein synthesis inhibition in neuronal activities - p. 355 22. Chapter 22. Rosacea and associated medical disorders - p. 426 23. Chapter 23. Bacterial internalization in cancer and other medical conditions: Intracellular pathogens - p. 450 24. Chapter 24. Ocular changes resulting from reading and writing on smartphone and computer: Computer vision syndrome, dry eye disease, meibomian gland dysfunction, chalazion, occupational overuse syndrome - p. 481 25. Chapter 25. Viral infections in vagus nerve - p. 493 26. Chapter 26. Microbial tryptamine in Type 1, Type 2, and Type 3 diabetes - p. 501 27. Index - p. 515
Microbiome Metabolome Brain Vagus Nerve Circuit in Disease and Recovery focuses on the emerging hypothesis of a dysfunctional microbiome metabolome vagus nerve brain circuit in Alzheimer’s disease and associated diseases and medical conditions, including dementia, aging, COVID-19, autoimmune conditions, and inflammatory skin condition rosacea, which may increase the risk of other conditions. This book also discusses the vagus nerve-related conditions, including Arnold’s reflex, laryngopharyngeal reflux, duodenogastric reflux, gastroesophageal reflux, and related pulmonary diseases. The subjects covered in the book also address an important question of which one is more important for human health and intellectual abilities: the human genome or the human microbiome? The conceptual model of food and gut microbial tryptamine vagus nerve circuit is also presented in this book.
1. Chapter 1. Introduction: Microbial metabolite interference of protein biosynthesis in neurodegenerative, neurodevelopmental, and other disorders; microbial metabolites hijacking vagus nerve - p. 1 2. Chapter 2. COVID-19: Scientific progress - p. 11 3. Chapter 3. Viral-bacterial interactions in diseases - p. 49 4. Chapter 4. Vagus nerve: Acid reflux, parietal cells, carpal tunnel syndrome, Alzheimer’s disease, COVID-19, stroke, cancer, and other diseases - p. 65 5. Chapter 5. Vagus nerve circuit: Microbiome—tryptophan metabolites—receptors and synapses - p. 83 6. Chapter 6. Glutamate and glutamate receptors in vagus nerve pathways and in Alzheimer’s disease - p. 115 7. Chapter 7. Aminoacyl tRNA synthetase multiple forms in autoimmune and infectious diseases - p. 131 8. Crystalized aromatic L-amino acid decarboxylase from bacteria Micrococcus percitreus catalyzing decarboxylation of tryptophan and L-DOPA (Levodopa or 3,4-dihydroxy-L-phenylalanine) - p. 147 9. Health effects of elevated CO2 levels, sparkling mineral water, seltzer carbonated water - p. 157 10. Chapter 10. Microbial antigens, allergies, and antibodies to microbial allergens: Significance of preexisting antibodies and stress for vaccination - p. 173 11. Chapter 11. Smell and taste identification deficits in disease - p. 187 12. Chapter 12. Microorganisms producing biogenic amines: From food to human body - p. 201 13. Chapter 13. Human genome or human microbiome genes: Which one is more important for human health and intellectual abilities? - p. 207 14. Chapter 14. Microorganisms used in agriculture, consumed from environment and associated with the edible raw fruits, vegetables, herbs, sprouts, and mushrooms - p. 241 15. Chapter 15. Molecular and cell aggregation: Biogenic amines, proteins, platelets, and microbial pathogens - p. 257 16. Chapter 16. Colonic diverticular disease as a risk factor for neurodegenerative and associated diseases - p. 267 17. Chapter 17. Alzheimer’s disease, dementia, aging, and COVID-19 - p. 291 18. Chapter 18. Existing vaccines and new and old tools - p. 309 19. Chapter 19. Serotonin syndrome in neurodegenerative diseases and COVID-19: Mechanisms and consequences of intestinal infection - p. 325 20. Chapter 20. Circulating cell-free mitochondria and membrane vesicles - p. 345 21. Chapter 21. Protein synthesis inhibition in neuronal activities - p. 355 22. Chapter 22. Rosacea and associated medical disorders - p. 426 23. Chapter 23. Bacterial internalization in cancer and other medical conditions: Intracellular pathogens - p. 450 24. Chapter 24. Ocular changes resulting from reading and writing on smartphone and computer: Computer vision syndrome, dry eye disease, meibomian gland dysfunction, chalazion, occupational overuse syndrome - p. 481 25. Chapter 25. Viral infections in vagus nerve - p. 493 26. Chapter 26. Microbial tryptamine in Type 1, Type 2, and Type 3 diabetes - p. 501 27. Index - p. 515
