"Cell niches are present in several human body tissues as a dynamic microenvironment essential to modulate stem cells’ behavior in health, under injury, and in regenerative processes. The interplay between stem cells and their niche is necessary for sustaining tissues. The extracellular matrix (ECM) is the crucial component of the stem cell. It defines the architectural space, physical binding to the cell membrane, and interactions with the neighborhood cells and supports physical stress. Domains with nano or micrometric sizes define the surface and topology of the ECM, mediating cell interactions and macrophage recruitment to injured sites.
Over the last two decades, the integration of biomedicine with other engineering and biomaterial sciences promoted the development of nanotechnology and regenerative medicine toward mimicking the specialized stem cell niches to treat diseases with less invasive and efficient therapies. Innovative approaches in nanotechnology, such as targeting the immunological system, transporting drugs across blood–brain/BBB and blood–retinal barriers/BRB, directing active moiety to specific disease location/organs, encapsulation of multiple components, and promoting signalization and pathway-specific surfaces for cell interactions and growth, are indeed promising. On the other side, developments of biomaterial scaffolds to mimic the cell niches for interactions with stem cells in vitro or in vivo have tremendous potential.
The three-dimensional printing technology offers a base for a wide array of applications, for example, developing tissue constructs, mimetic organs, organoids, and organ-on-a-chip, thus avoiding the differences between animal model species and humans. Aiming closer to the natural environments, fresh autologous products from the blood, such as platelet-rich plasma (PRP), contain platelets and leukocytes, providing growth factors, cytokines, and proteins for the resident stem cells in the stages of regeneration. PRP also provides pain relief, reducing disabilities in elderly or diseased people. This book brings thought-provoking multidisciplinary topics on the diverse aspects of basic and applied sciences. The prime focus of the compilation is to understand the challenges researchers encounter in combining nanotechnology and regenerative medicine, ultimately integrating both disciplines for the benefit of the patient and offering them a ray of hope to be cured.
1. Nanotechnology and Regenerative Medicine - p. i 2. Cover - p. i 3. Title Page - p. ii 4. Copyright Page - p. iv 5. Table of Contents - p. v 6. List of Contributors - p. xvii 7. Preface - p. xxiii 8. Chapter 1 Progress of nanotechnology in the development of medicines - p. 1 9. Chapter 2 History and evolution of regenerative medicine - p. 23 10. Chapter 3 Nanotechnologies to deliver drugs through the blood–brain and blood–retinal barriers - p. 45 11. Chapter 4 Thermodynamics of nanoparticle–cell interaction - p. 65 12. Chapter 5 Nanogels for drug delivery: physicochemical properties, biological behavior, and in vivo applications - p. 95 13. Chapter 6 The role of blood–brain and blood–retinal barriers in drug delivery - p. 133 14. Chapter 7 Nanotechnology and stem cell therapy for combating COVID-19 - p. 155 15. Chapter 8 Lipid nanoparticles-based semisolid formulations for cosmetic applications: focus on cellulite - p. 179 16. Chapter 9 3D bioprinting: An innovative technique for biofabrication applied to regenerative medicine and tissue engineering - p. 195 17. Chapter 10 Stem cells, organoids, and cellular therapy - p. 233 18. Chapter 11 Platelet-rich plasma, their growth factors, cytokines and clinical use - p. 265 19. Chapter 12 The biomaterial niche of platelet-rich plasma and hyaluronic acid matrices for tissue regeneration - p. 315 20. Chapter 13 Applications of biomaterials in wound healing management: from fundamental physiology to advanced technology - p. 349 21. Chapter 14 Nanoscaffolds and role of 3D-printed surgical dressings for wound healing application - p. 371 22. Chapter 15 Platelet-rich plasma in pain management - p. 397 23. Chapter 16 Tissue engineering in wound healing - p. 411 24. Chapter 17 Role of neurogenesis in regenerative medicine - p. 455 25. Chapter 18 Gut microbiome interventions in regenerative medicine - p. 477 26. Chapter 19 Applications of nanotechnology in chronic diseases and tissue regeneration - p. 507 27. Chapter 20 Electrically conductive nanomaterials for advanced cardiac tissue regeneration - p. 529 28. Chapter 21 Toxicological screening of nanoparticles for biological applications: Drosophila melanogaster as a representative toxicological model - p. 551 29. Index - p. 575
"Cell niches are present in several human body tissues as a dynamic microenvironment essential to modulate stem cells’ behavior in health, under injury, and in regenerative processes. The interplay between stem cells and their niche is necessary for sustaining tissues. The extracellular matrix (ECM) is the crucial component of the stem cell. It defines the architectural space, physical binding to the cell membrane, and interactions with the neighborhood cells and supports physical stress. Domains with nano or micrometric sizes define the surface and topology of the ECM, mediating cell interactions and macrophage recruitment to injured sites.
Over the last two decades, the integration of biomedicine with other engineering and biomaterial sciences promoted the development of nanotechnology and regenerative medicine toward mimicking the specialized stem cell niches to treat diseases with less invasive and efficient therapies. Innovative approaches in nanotechnology, such as targeting the immunological system, transporting drugs across blood–brain/BBB and blood–retinal barriers/BRB, directing active moiety to specific disease location/organs, encapsulation of multiple components, and promoting signalization and pathway-specific surfaces for cell interactions and growth, are indeed promising. On the other side, developments of biomaterial scaffolds to mimic the cell niches for interactions with stem cells in vitro or in vivo have tremendous potential.
The three-dimensional printing technology offers a base for a wide array of applications, for example, developing tissue constructs, mimetic organs, organoids, and organ-on-a-chip, thus avoiding the differences between animal model species and humans. Aiming closer to the natural environments, fresh autologous products from the blood, such as platelet-rich plasma (PRP), contain platelets and leukocytes, providing growth factors, cytokines, and proteins for the resident stem cells in the stages of regeneration. PRP also provides pain relief, reducing disabilities in elderly or diseased people. This book brings thought-provoking multidisciplinary topics on the diverse aspects of basic and applied sciences. The prime focus of the compilation is to understand the challenges researchers encounter in combining nanotechnology and regenerative medicine, ultimately integrating both disciplines for the benefit of the patient and offering them a ray of hope to be cured.
1. Nanotechnology and Regenerative Medicine - p. i 2. Cover - p. i 3. Title Page - p. ii 4. Copyright Page - p. iv 5. Table of Contents - p. v 6. List of Contributors - p. xvii 7. Preface - p. xxiii 8. Chapter 1 Progress of nanotechnology in the development of medicines - p. 1 9. Chapter 2 History and evolution of regenerative medicine - p. 23 10. Chapter 3 Nanotechnologies to deliver drugs through the blood–brain and blood–retinal barriers - p. 45 11. Chapter 4 Thermodynamics of nanoparticle–cell interaction - p. 65 12. Chapter 5 Nanogels for drug delivery: physicochemical properties, biological behavior, and in vivo applications - p. 95 13. Chapter 6 The role of blood–brain and blood–retinal barriers in drug delivery - p. 133 14. Chapter 7 Nanotechnology and stem cell therapy for combating COVID-19 - p. 155 15. Chapter 8 Lipid nanoparticles-based semisolid formulations for cosmetic applications: focus on cellulite - p. 179 16. Chapter 9 3D bioprinting: An innovative technique for biofabrication applied to regenerative medicine and tissue engineering - p. 195 17. Chapter 10 Stem cells, organoids, and cellular therapy - p. 233 18. Chapter 11 Platelet-rich plasma, their growth factors, cytokines and clinical use - p. 265 19. Chapter 12 The biomaterial niche of platelet-rich plasma and hyaluronic acid matrices for tissue regeneration - p. 315 20. Chapter 13 Applications of biomaterials in wound healing management: from fundamental physiology to advanced technology - p. 349 21. Chapter 14 Nanoscaffolds and role of 3D-printed surgical dressings for wound healing application - p. 371 22. Chapter 15 Platelet-rich plasma in pain management - p. 397 23. Chapter 16 Tissue engineering in wound healing - p. 411 24. Chapter 17 Role of neurogenesis in regenerative medicine - p. 455 25. Chapter 18 Gut microbiome interventions in regenerative medicine - p. 477 26. Chapter 19 Applications of nanotechnology in chronic diseases and tissue regeneration - p. 507 27. Chapter 20 Electrically conductive nanomaterials for advanced cardiac tissue regeneration - p. 529 28. Chapter 21 Toxicological screening of nanoparticles for biological applications: Drosophila melanogaster as a representative toxicological model - p. 551 29. Index - p. 575
