Neuroinflammation, Second Edition, discusses the role inflammation plays in neuro-inflammatory diseases. As research in neuroinflammation has dramatically increased in recent years, this new edition covers all of the new developments and findings since the first publication nearly a decade ago. Comprehensive coverage of topics includes chapters on multiple sclerosis, optic neuritis and Susac syndrome. New chapters cover the latest research in Epilepsy and Neuroinflammation, Pediatric MS, Pediatric Lupus and Traumatic Brain Injury, amongst other topics.
Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, brain trauma and meningitis, and it contributes to the generation of pain. Researchers are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage, through tolerance, and to modulation and repair.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xxi 6. Preface - p. xxv 7. Chapter 1. Multiple Sclerosis: Clinical Features, Pathophysiology, Diagnosis, and Management - p. 1 8. Chapter 2. Neutralizing Antibodies and Multiple Sclerosis in the Era of Disease Modifying Treatments - p. 21 9. Chapter 3. Animal Models of Multiple Sclerosis - p. 37 10. Chapter 4. Neuroimaging of Multiple Sclerosis and Other Immune-Mediated Diseases of Central Nervous System: An Update - p. 73 11. Chapter 5. Role of IL-12/IL-23 in the Pathogenesis of Multiple Sclerosis - p. 115 12. Chapter 6. Acute Transverse Myelitis: Clinical Features, Pathophysiology, and Treatment Options - p. 141 13. Chapter 7. Remyelination in Multiple Sclerosis: A Mechanistic Look - p. 163 14. Chapter 8. The Way Forward With Vitamin D in Multiple Sclerosis - p. 175 15. Chapter 9. Autoimmune Encephalitis: Clinical Features, Pathophysiology, and Management - p. 193 16. Chapter 10. Immune Dysregulation in Epilepsy - p. 217 17. Chapter 11. Neurosarcoidosis: Clinical Features, Pathophysiology, and Management - p. 233 18. Chapter 12. Existing and Emerging Therapies for Multiple Sclerosis - p. 247 19. Chapter 13. Tumefactive Demyelination in Multiple Sclerosis: Clinical Presentation, Pathophysiology and Treatment Options - p. 261 20. Chapter 14. Pediatric Multiple Sclerosis - p. 277 21. Chapter 15. Acute Disseminated Encephalomyelitis: Clinical Presentation, Pathophysiology, Diagnosis, and Treatment - p. 295 22. Chapter 16. Neuromyelitis Optica Spectrum Disorders - p. 313 23. Chapter 17. Optic Neuritis: Clinical Manifestations, Pathophysiology, and Management - p. 337 24. Chapter 18. Ischemic Demyelination - p. 355 25. Chapter 19. Inflammatory Mechanisms in Ischemic Cerebrovascular Disease - p. 379 26. Chapter 20. Two-Pore Domain Potassium Channels (K2Ps) as Drug Targets in Neuroinflammation - p. 413 27. Chapter 21. Interferon Gamma Versus Beta-Interferon in Pathogenesis of Multiple Sclerosis: Battle of Two Interferons - p. 429 28. Chapter 22. Inflammatory Mediators in Obstructive Sleep Apnea - p. 449 29. Chapter 23. Central Nervous System Vasculitis - p. 493 30. Chapter 24. Role of Inflammatory Mechanisms in Guillain-Barre’ Syndrome - p. 505 31. Chapter 25. Roles of Macrophages and Astrocytes in Pathogenesis of Multiple Sclerosis - p. 517 32. Chapter 26. Blood-Brain Barrier Disruption During Neuroinflammation - p. 529 33. Chapter 27. Roles of Toll-Like Receptors in Pathophysiology of Alzheimer’s Disease and Multiple Sclerosis - p. 541 34. Chapter 28. Role of Neuroinflammation in the Pathophysiology of Traumatic Brain Injury - p. 563 35. Chapter 29. The Contribution of Extra Cranial Venous Drainage to Neuro-Inflammation in Multiple Sclerosis - p. 579 36. Chapter 30. Lymphatic Drainage of the CNS and Its Role in Neuroinflammation and Neurodegenerative Disease - p. 601 37. Chapter 31. A Complete Review on Epigenetic Biomarkers in MS - p. 619 38. Index - p. 639
Neuroinflammation, Second Edition, discusses the role inflammation plays in neuro-inflammatory diseases. As research in neuroinflammation has dramatically increased in recent years, this new edition covers all of the new developments and findings since the first publication nearly a decade ago. Comprehensive coverage of topics includes chapters on multiple sclerosis, optic neuritis and Susac syndrome. New chapters cover the latest research in Epilepsy and Neuroinflammation, Pediatric MS, Pediatric Lupus and Traumatic Brain Injury, amongst other topics.
Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, brain trauma and meningitis, and it contributes to the generation of pain. Researchers are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage, through tolerance, and to modulation and repair.
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xxi 6. Preface - p. xxv 7. Chapter 1. Multiple Sclerosis: Clinical Features, Pathophysiology, Diagnosis, and Management - p. 1 8. Chapter 2. Neutralizing Antibodies and Multiple Sclerosis in the Era of Disease Modifying Treatments - p. 21 9. Chapter 3. Animal Models of Multiple Sclerosis - p. 37 10. Chapter 4. Neuroimaging of Multiple Sclerosis and Other Immune-Mediated Diseases of Central Nervous System: An Update - p. 73 11. Chapter 5. Role of IL-12/IL-23 in the Pathogenesis of Multiple Sclerosis - p. 115 12. Chapter 6. Acute Transverse Myelitis: Clinical Features, Pathophysiology, and Treatment Options - p. 141 13. Chapter 7. Remyelination in Multiple Sclerosis: A Mechanistic Look - p. 163 14. Chapter 8. The Way Forward With Vitamin D in Multiple Sclerosis - p. 175 15. Chapter 9. Autoimmune Encephalitis: Clinical Features, Pathophysiology, and Management - p. 193 16. Chapter 10. Immune Dysregulation in Epilepsy - p. 217 17. Chapter 11. Neurosarcoidosis: Clinical Features, Pathophysiology, and Management - p. 233 18. Chapter 12. Existing and Emerging Therapies for Multiple Sclerosis - p. 247 19. Chapter 13. Tumefactive Demyelination in Multiple Sclerosis: Clinical Presentation, Pathophysiology and Treatment Options - p. 261 20. Chapter 14. Pediatric Multiple Sclerosis - p. 277 21. Chapter 15. Acute Disseminated Encephalomyelitis: Clinical Presentation, Pathophysiology, Diagnosis, and Treatment - p. 295 22. Chapter 16. Neuromyelitis Optica Spectrum Disorders - p. 313 23. Chapter 17. Optic Neuritis: Clinical Manifestations, Pathophysiology, and Management - p. 337 24. Chapter 18. Ischemic Demyelination - p. 355 25. Chapter 19. Inflammatory Mechanisms in Ischemic Cerebrovascular Disease - p. 379 26. Chapter 20. Two-Pore Domain Potassium Channels (K2Ps) as Drug Targets in Neuroinflammation - p. 413 27. Chapter 21. Interferon Gamma Versus Beta-Interferon in Pathogenesis of Multiple Sclerosis: Battle of Two Interferons - p. 429 28. Chapter 22. Inflammatory Mediators in Obstructive Sleep Apnea - p. 449 29. Chapter 23. Central Nervous System Vasculitis - p. 493 30. Chapter 24. Role of Inflammatory Mechanisms in Guillain-Barre’ Syndrome - p. 505 31. Chapter 25. Roles of Macrophages and Astrocytes in Pathogenesis of Multiple Sclerosis - p. 517 32. Chapter 26. Blood-Brain Barrier Disruption During Neuroinflammation - p. 529 33. Chapter 27. Roles of Toll-Like Receptors in Pathophysiology of Alzheimer’s Disease and Multiple Sclerosis - p. 541 34. Chapter 28. Role of Neuroinflammation in the Pathophysiology of Traumatic Brain Injury - p. 563 35. Chapter 29. The Contribution of Extra Cranial Venous Drainage to Neuro-Inflammation in Multiple Sclerosis - p. 579 36. Chapter 30. Lymphatic Drainage of the CNS and Its Role in Neuroinflammation and Neurodegenerative Disease - p. 601 37. Chapter 31. A Complete Review on Epigenetic Biomarkers in MS - p. 619 38. Index - p. 639
