GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in cancer, Emerging GPCR signaling pathways in cancer, and more.
G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors which are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and they are targeted by nearly one third of the currently prescribed drugs including anti-cancer therapeutics.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_vii 6. Chapter One: Atypical chemokine receptors in tumor cell growth and metastasis - p. page_vii 7. Chapter Two: The G protein coupled receptor CCR5 in cancer - p. page_27 8. Chapter Three: Targeting G protein-coupled receptors in cancer therapy - p. page_47 9. Chapter Four: The diverse and complex roles of atypical chemokine receptors in cancer: From molecular biology to clinical relevance and therapy - p. page_97 10. Chapter Five: Structure and function of β-arrestins, their emerging role in breast cancer, and potential opportunities for therapeutic manipulation - p. page_138
GPCR Signaling in Cancer, Volume 145, the latest release in the Advances in Cancer Research series, highlights recent developments in the area of GPCRs and cancer biology. Chapters included in this volume cover several GPCRs and their downstream effectors as case examples to highlight their fundamental understanding and therapeutic potential. Specific chapters address the Role of GRKs and beta-arrestins in cancer, Atypical GPCRs in cancer, the Role of a chemokine receptor (CCR) 5 in cancer, Targeting G protein-coupled receptors for therapeutics in cancer, Emerging GPCR signaling pathways in cancer, and more.
G protein-coupled receptors (GPCRs) constitute a large family of cell surface receptors which are involved in nearly every cellular and physiological event. These receptors can recognize a broad array of ligands and they are targeted by nearly one third of the currently prescribed drugs including anti-cancer therapeutics.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_vii 6. Chapter One: Atypical chemokine receptors in tumor cell growth and metastasis - p. page_vii 7. Chapter Two: The G protein coupled receptor CCR5 in cancer - p. page_27 8. Chapter Three: Targeting G protein-coupled receptors in cancer therapy - p. page_47 9. Chapter Four: The diverse and complex roles of atypical chemokine receptors in cancer: From molecular biology to clinical relevance and therapy - p. page_97 10. Chapter Five: Structure and function of β-arrestins, their emerging role in breast cancer, and potential opportunities for therapeutic manipulation - p. page_138
