This is not a book on NO biology, nor about hemoglobin, nor about heme-based sensors per se. Of course, it covers all these topics and more, but above all, it aims at providing a truly multidisciplinary perspective of heme-diatomic interactions. The overarching goal is to build bridges among disciplines, to bring about a meeting of minds.
The contributors to this book hail from diverse university departments and disciplines – chemistry, biochemistry, molecular biology, microbiology, zoology, physics, medicine and surgery, bringing with them very different views of heme-diatomic interactions. The hope is that the juxtaposition of this diversity will lead to increased exchanges of ideas, approaches, and techniques across traditional disciplinary boundaries.
The authors represent a veritable Who’s Who of heme protein research and include John Olson, Tom Spiro, Walter Zumft, F. Ann Walker, Teizo Kitagawa, W. Robert Scheidt, Pat Farmer, Marie-Alda Gilles-Gonzalez, and many other equally distinguished scientists.
Extremely distinguished list of authors
Multidisciplinary character – equally suitable for chemists and biochemists
Covers the hottest topics in heme protein research: sensors, NO biology, new roles of hemoglobin, etc.
1. Cover image 2. Title page 3. Table of Contents 4. Copyright 5. Preface 6. PART I: INTRODUCTORY OVERVIEWS 7. Chapter 1: Mammalian Myoglobin as a Model for Understanding Ligand Affinities and Discrimination in Heme Proteins 8. Chapter 2: A Surfeit of Biological Heme-based Sensors 9. Chapter 3: NO and NOx Interactions with Hemes 10. PART II: ELECTRONIC STRUCTURE AND SPECTROSCOPY 11. Chapter 4: CO, NO, and O2 as Vibrational Probes of Heme Protein Active Sites 12. Chapter 5: Nuclear Resonance Vibrational Spectroscopy — NRVS 13. Chapter 6: EPR and Low-temperature MCD Spectroscopy of Ferrous Heme Nitrosyls 14. PART III: ASPECTS OF HEMOGLOBINS (EXCEPT HEME–NOx INTERACTIONS) 15. Chapter 7: Protoglobin and Globin-coupled Sensors 16. Chapter 8: Neuroglobin and Cytoglobin 17. Chapter 9: Extreme pH Sensitivity in the Binding of Oxygen to Some Fish Hemoglobins 18. Chapter 10: Microbial Hemoglobins 19. PART IV: HEME–NOx INTERACTIONS 20. Chapter 11: The Reaction between Nitrite and Hemoglobin: The Role of Nitrite in Hemoglobin-mediated Hypoxic Vasodilation 21. Chapter 12: Nitric Oxide Dioxygenase: An Ancient Enzymic 22. Chapter 13: Respiratory Nitric Oxide Reductases, NorB and NorZ, of the Heme–Copper Oxidase Type 23. Chapter 14: Nitric Oxide Reductase (P450nor) from Fusarium oxysporum 24. Chapter 15: Nitric Oxide Interaction with Insect Nitrophorins and Possibilities for the Electron Configuration of the {FeNO}6 Complex 25. Chapter 16: Bioinorganic Chemistry of the HNO Ligand 26. PART V: SELECTED ENZYMES AND SENSORS 27. Chapter 17: Ligand-Protein Interactions in Mammalian Nitric Oxide Synthase 28. Chapter 18: CooA: A Paradigm for Gas-sensing Regulatory Proteins 29. Chapter 19: Soluble Guanylyl Cyclase and Its Evolutionary Relatives 30. Chapter 20: Resonance Raman Studies of the Activation Mechanism of Soluble Guanylate Cyclase 31. Chapter 21: Insights into Heme-based O2 Sensing from Structure–Function Relationships in the FixL Proteins 32. Index
This is not a book on NO biology, nor about hemoglobin, nor about heme-based sensors per se. Of course, it covers all these topics and more, but above all, it aims at providing a truly multidisciplinary perspective of heme-diatomic interactions. The overarching goal is to build bridges among disciplines, to bring about a meeting of minds.
The contributors to this book hail from diverse university departments and disciplines – chemistry, biochemistry, molecular biology, microbiology, zoology, physics, medicine and surgery, bringing with them very different views of heme-diatomic interactions. The hope is that the juxtaposition of this diversity will lead to increased exchanges of ideas, approaches, and techniques across traditional disciplinary boundaries.
The authors represent a veritable Who’s Who of heme protein research and include John Olson, Tom Spiro, Walter Zumft, F. Ann Walker, Teizo Kitagawa, W. Robert Scheidt, Pat Farmer, Marie-Alda Gilles-Gonzalez, and many other equally distinguished scientists.
Extremely distinguished list of authors
Multidisciplinary character – equally suitable for chemists and biochemists
Covers the hottest topics in heme protein research: sensors, NO biology, new roles of hemoglobin, etc.
1. Cover image 2. Title page 3. Table of Contents 4. Copyright 5. Preface 6. PART I: INTRODUCTORY OVERVIEWS 7. Chapter 1: Mammalian Myoglobin as a Model for Understanding Ligand Affinities and Discrimination in Heme Proteins 8. Chapter 2: A Surfeit of Biological Heme-based Sensors 9. Chapter 3: NO and NOx Interactions with Hemes 10. PART II: ELECTRONIC STRUCTURE AND SPECTROSCOPY 11. Chapter 4: CO, NO, and O2 as Vibrational Probes of Heme Protein Active Sites 12. Chapter 5: Nuclear Resonance Vibrational Spectroscopy — NRVS 13. Chapter 6: EPR and Low-temperature MCD Spectroscopy of Ferrous Heme Nitrosyls 14. PART III: ASPECTS OF HEMOGLOBINS (EXCEPT HEME–NOx INTERACTIONS) 15. Chapter 7: Protoglobin and Globin-coupled Sensors 16. Chapter 8: Neuroglobin and Cytoglobin 17. Chapter 9: Extreme pH Sensitivity in the Binding of Oxygen to Some Fish Hemoglobins 18. Chapter 10: Microbial Hemoglobins 19. PART IV: HEME–NOx INTERACTIONS 20. Chapter 11: The Reaction between Nitrite and Hemoglobin: The Role of Nitrite in Hemoglobin-mediated Hypoxic Vasodilation 21. Chapter 12: Nitric Oxide Dioxygenase: An Ancient Enzymic 22. Chapter 13: Respiratory Nitric Oxide Reductases, NorB and NorZ, of the Heme–Copper Oxidase Type 23. Chapter 14: Nitric Oxide Reductase (P450nor) from Fusarium oxysporum 24. Chapter 15: Nitric Oxide Interaction with Insect Nitrophorins and Possibilities for the Electron Configuration of the {FeNO}6 Complex 25. Chapter 16: Bioinorganic Chemistry of the HNO Ligand 26. PART V: SELECTED ENZYMES AND SENSORS 27. Chapter 17: Ligand-Protein Interactions in Mammalian Nitric Oxide Synthase 28. Chapter 18: CooA: A Paradigm for Gas-sensing Regulatory Proteins 29. Chapter 19: Soluble Guanylyl Cyclase and Its Evolutionary Relatives 30. Chapter 20: Resonance Raman Studies of the Activation Mechanism of Soluble Guanylate Cyclase 31. Chapter 21: Insights into Heme-based O2 Sensing from Structure–Function Relationships in the FixL Proteins 32. Index
