Through five well-regarded editions, Dr. David Dabbs’ Diagnostic Immunohistochemistry has set the standard for concise, complete, guidance on the use and interpretation of immunohistochemical stains. The 6th Edition continues this tradition of excellence, bringing you fully up to date with all aspects of this dynamic field. Easy to use and understand, this practical resource distills the large body of information on immunohistochemistry into a single, convenient reference that is invaluable for today’s surgical pathologists.
Covers all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options.
Includes the latest grading schemes in several organs along with new antibodies to cover more genomic immunohistochemistry applications.
Contains current biomarker guidelines and up-to-date references throughout.
Offers a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors.
Contains numerous charts and tables, as well as 1,500 high-quality color histologic images that assist in making a definitive diagnosis.
Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses.
Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval.
1. Introduction - p. 254 2. Squamoproliferative Lesions - p. 254 3. Nasal Cavity and Paranasal Sinuses - p. 259 4. Nasopharynx - p. 291 5. Oral Cavity - p. 297 6. Larynx/Hypopharynx - p. 300 7. Salivary Glands - p. 304 8. Ear and Temporal Bone - p. 328 9. Metastatic Tumors - p. 338 10. Summary - p. 341 11. 10. Immunohistology of Endocrine and Neuroendocrine Neoplasms - p. 342 12. Overview - p. 342 13. Biology of Antigens and Antibodies - p. 342 14. Tumors of Specific Sites - p. 346 15. Neuroendocrine Tumors in Other Sites - p. 387 16. Summary - p. 392 17. 11. Immunohistology of the Mediastinum - p. 393 18. 12. Immunohistology of Pulmonary and Pleural Neoplasms - p. 434 19. 13. Immunohistology of Skin Tumors - p. 498 20. 14. Immunohistology of the Gastrointestinal Tract - p. 528 21. Biology of Antigens and Antibodies: General and Tissue Specific - p. 528 22. Diagnostic Immunohistochemistry: Epithelial Lesions of the Gastrointestinal Tract - p. 530 23. Diagnostic Immunohistochemistry: Neuroendocrine Neoplasms of the Gastrointestinal Tract - p. 549 24. Diagnostic Immunohistochemistry: Mesenchymal Lesions of the Gastrointestinal Tract - p. 553 25. Beyond Immunohistochemistry: Theranostic and Genomic Applications - p. 558 26. Summary - p. 560.e11 27. 15. Immunohistology of Pancreas and Hepatobiliary Tract - p. 561 28. Pancreas - p. 561 29. Extrahepatic Biliary Tract (Extrahepatic Bile Ducts and Gallbladder) - p. 580 30. Ampulla - p. 584 31. Liver - p. 588 32. Summary - p. 605 33. 16. Immunohistology of the Prostate - p. 607 34. 17. Immunohistology of the Bladder, Kidney, and Testis - p. 642 35. Overview - p. 642 36. Immunohistology of the Urinary Bladder - p. 642 37. Immunohistology of Renal Neoplasms - p. 659 38. Immunohistology of Testicular Tumors - p. 674 39. Summary - p. 681 40. 18. Immunohistology of the Female Genital Tract - p. 683 41. Biology of Antigens and Antibodies - p. 683 42. Lower Female Genital Tract and Uterus - p. 687 43. Upper Female Genital Tract - p. 718 44. Summary - p. 741 45. 19. Immunohistology of the Breast - p. 742 46. Introduction - p. 742 47. Myoepithelial Cells and Assessment of Stromal Invasion - p. 742 48. Immunohistochemistry of Papillary Lesions - p. 748 49. Proliferative Ductal Epithelial Lesions and In Situ Carcinoma - p. 752 50. Tumor Type Identification by Immunohistochemistry - p. 752 51. Immunohistochemistry for Identifying Special Types of Breast Carcinomas - p. 759 52. Paget Disease of the Breast - p. 764 53. Detection of Lymphatic Space Invasion - p. 765 54. Sentinel Lymph Node Examination - p. 766 55. Systemic Metastasis of Breast Carcinoma - p. 770 56. Fibroepithelial Tumors - p. 772 57. Theranostic Applications - p. 776 58. Genomic Applications of Immunohistochemistry: Breast Cancer Molecular Classification and Immunogenomics - p. 784 59. Other Tumor Markers - p. 791 60. Summary - p. 796 61. 20. Immunohistology of the Nervous System - p. 797 62. Overview - p. 797 63. Clinical and Radiologic Perspective of Lesions - p. 798 64. Nonneoplastic Brain Lesions - p. 800 65. Tumors of the Nervous System - p. 809 66. Cysts of the Nervous System - p. 865 67. Dementias - p. 866 68. Demyelination - p. 868 69. Epilepsy - p. 869 70. Cortical Malformations - p. 869 71. Pitfalls in Diagnosis - p. 869 72. Summary - p. 875 73. 21. Immunocytology - p. 876 74. 22. Immunohistology of Pediatric Neoplasms - p. 905 75. 23. Imaging and Quantitative Immunohistochemistry - p. 927 76. 24. Molecular Anatomic Pathology: Principles, Techniques, and Application to Immunohistologic Diagnosis - p. 936 77. INDEX - p. 953
Through five well-regarded editions, Dr. David Dabbs’ Diagnostic Immunohistochemistry has set the standard for concise, complete, guidance on the use and interpretation of immunohistochemical stains. The 6th Edition continues this tradition of excellence, bringing you fully up to date with all aspects of this dynamic field. Easy to use and understand, this practical resource distills the large body of information on immunohistochemistry into a single, convenient reference that is invaluable for today’s surgical pathologists.
Covers all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options.
Includes the latest grading schemes in several organs along with new antibodies to cover more genomic immunohistochemistry applications.
Contains current biomarker guidelines and up-to-date references throughout.
Offers a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors.
Contains numerous charts and tables, as well as 1,500 high-quality color histologic images that assist in making a definitive diagnosis.
Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses.
Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval.
1. Introduction - p. 254 2. Squamoproliferative Lesions - p. 254 3. Nasal Cavity and Paranasal Sinuses - p. 259 4. Nasopharynx - p. 291 5. Oral Cavity - p. 297 6. Larynx/Hypopharynx - p. 300 7. Salivary Glands - p. 304 8. Ear and Temporal Bone - p. 328 9. Metastatic Tumors - p. 338 10. Summary - p. 341 11. 10. Immunohistology of Endocrine and Neuroendocrine Neoplasms - p. 342 12. Overview - p. 342 13. Biology of Antigens and Antibodies - p. 342 14. Tumors of Specific Sites - p. 346 15. Neuroendocrine Tumors in Other Sites - p. 387 16. Summary - p. 392 17. 11. Immunohistology of the Mediastinum - p. 393 18. 12. Immunohistology of Pulmonary and Pleural Neoplasms - p. 434 19. 13. Immunohistology of Skin Tumors - p. 498 20. 14. Immunohistology of the Gastrointestinal Tract - p. 528 21. Biology of Antigens and Antibodies: General and Tissue Specific - p. 528 22. Diagnostic Immunohistochemistry: Epithelial Lesions of the Gastrointestinal Tract - p. 530 23. Diagnostic Immunohistochemistry: Neuroendocrine Neoplasms of the Gastrointestinal Tract - p. 549 24. Diagnostic Immunohistochemistry: Mesenchymal Lesions of the Gastrointestinal Tract - p. 553 25. Beyond Immunohistochemistry: Theranostic and Genomic Applications - p. 558 26. Summary - p. 560.e11 27. 15. Immunohistology of Pancreas and Hepatobiliary Tract - p. 561 28. Pancreas - p. 561 29. Extrahepatic Biliary Tract (Extrahepatic Bile Ducts and Gallbladder) - p. 580 30. Ampulla - p. 584 31. Liver - p. 588 32. Summary - p. 605 33. 16. Immunohistology of the Prostate - p. 607 34. 17. Immunohistology of the Bladder, Kidney, and Testis - p. 642 35. Overview - p. 642 36. Immunohistology of the Urinary Bladder - p. 642 37. Immunohistology of Renal Neoplasms - p. 659 38. Immunohistology of Testicular Tumors - p. 674 39. Summary - p. 681 40. 18. Immunohistology of the Female Genital Tract - p. 683 41. Biology of Antigens and Antibodies - p. 683 42. Lower Female Genital Tract and Uterus - p. 687 43. Upper Female Genital Tract - p. 718 44. Summary - p. 741 45. 19. Immunohistology of the Breast - p. 742 46. Introduction - p. 742 47. Myoepithelial Cells and Assessment of Stromal Invasion - p. 742 48. Immunohistochemistry of Papillary Lesions - p. 748 49. Proliferative Ductal Epithelial Lesions and In Situ Carcinoma - p. 752 50. Tumor Type Identification by Immunohistochemistry - p. 752 51. Immunohistochemistry for Identifying Special Types of Breast Carcinomas - p. 759 52. Paget Disease of the Breast - p. 764 53. Detection of Lymphatic Space Invasion - p. 765 54. Sentinel Lymph Node Examination - p. 766 55. Systemic Metastasis of Breast Carcinoma - p. 770 56. Fibroepithelial Tumors - p. 772 57. Theranostic Applications - p. 776 58. Genomic Applications of Immunohistochemistry: Breast Cancer Molecular Classification and Immunogenomics - p. 784 59. Other Tumor Markers - p. 791 60. Summary - p. 796 61. 20. Immunohistology of the Nervous System - p. 797 62. Overview - p. 797 63. Clinical and Radiologic Perspective of Lesions - p. 798 64. Nonneoplastic Brain Lesions - p. 800 65. Tumors of the Nervous System - p. 809 66. Cysts of the Nervous System - p. 865 67. Dementias - p. 866 68. Demyelination - p. 868 69. Epilepsy - p. 869 70. Cortical Malformations - p. 869 71. Pitfalls in Diagnosis - p. 869 72. Summary - p. 875 73. 21. Immunocytology - p. 876 74. 22. Immunohistology of Pediatric Neoplasms - p. 905 75. 23. Imaging and Quantitative Immunohistochemistry - p. 927 76. 24. Molecular Anatomic Pathology: Principles, Techniques, and Application to Immunohistologic Diagnosis - p. 936 77. INDEX - p. 953
