Acute respiratory infections are responsible for an estimated 4 million deaths annually worldwide, and are the leading cause of death in children younger than 5 years. Over 1 million people in the United States are hospitalized each year with pneumonia. Mycobacterium tuberculosis infects one third of world’s population. There are more than 1 million tuberculosis-related deaths worldwide each year. Emerging resistance to multiple available antimicrobial agents has hampered the ability to treat tuberculosis and hospital-acquired respiratory infections. The laboratory diagnosis of respiratory infections is an important part of patient management and treatment. In addition to culture isolation of pathogens, advances have been made in a number of non-culture methods. This issue of Clinics in Laboratory Medicinee reviews state-of-the-art laboratory diagnosis of respiratory infections, as well as the testing of susceptibility to antibiotics and antiviral agents. Among some of the respiratory infections covered are: Cystic fibrosis infections; Pertussis; Pharyngitis; Fungal infections. Among the diagnostic tests are: Interferon gamma release assays; Molecuar diagnosis of TB; Urine antigen tests and discussion of Antibiotic resistance in nosocomial respiratory infections.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 5 6. Preface - p. 6 7. Infections in Patients with Cystic Fibrosis - p. 7 8. Urine Antigen Tests for the Diagnosis of Respiratory Infections - p. 20 9. Pertussis - p. 31 10. Antibiotic Resistance in Nosocomial Respiratory Infections - p. 42 11. Nontuberculous Mycobacteria in Respiratory Infections - p. 50 12. Molecular Diagnosis of Tuberculosis and Drug Resistance - p. 64 13. Nonmolecular Methods for the Diagnosis of Respiratory Fungal Infections - p. 75 14. Interferon-Gamma Release Assays - p. 88 15. Respiratory Fungal Infections - p. 96 16. Rapid Diagnosis of Influenza - p. 104 17. Antiviral Resistance in Influenza Viruses - p. 113 18. Emerging Respiratory Viruses Other than Influenza - p. 126 19. Index - p. 139
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Acute respiratory infections are responsible for an estimated 4 million deaths annually worldwide, and are the leading cause of death in children younger than 5 years. Over 1 million people in the United States are hospitalized each year with pneumonia. Mycobacterium tuberculosis infects one third of world’s population. There are more than 1 million tuberculosis-related deaths worldwide each year. Emerging resistance to multiple available antimicrobial agents has hampered the ability to treat tuberculosis and hospital-acquired respiratory infections. The laboratory diagnosis of respiratory infections is an important part of patient management and treatment. In addition to culture isolation of pathogens, advances have been made in a number of non-culture methods. This issue of Clinics in Laboratory Medicinee reviews state-of-the-art laboratory diagnosis of respiratory infections, as well as the testing of susceptibility to antibiotics and antiviral agents. Among some of the respiratory infections covered are: Cystic fibrosis infections; Pertussis; Pharyngitis; Fungal infections. Among the diagnostic tests are: Interferon gamma release assays; Molecuar diagnosis of TB; Urine antigen tests and discussion of Antibiotic resistance in nosocomial respiratory infections.
1. Cover image - p. 1 2. Title page - p. 2 3. Table of Contents - p. 3 4. Contributors - p. 4 5. Forthcoming Issues - p. 5 6. Preface - p. 6 7. Infections in Patients with Cystic Fibrosis - p. 7 8. Urine Antigen Tests for the Diagnosis of Respiratory Infections - p. 20 9. Pertussis - p. 31 10. Antibiotic Resistance in Nosocomial Respiratory Infections - p. 42 11. Nontuberculous Mycobacteria in Respiratory Infections - p. 50 12. Molecular Diagnosis of Tuberculosis and Drug Resistance - p. 64 13. Nonmolecular Methods for the Diagnosis of Respiratory Fungal Infections - p. 75 14. Interferon-Gamma Release Assays - p. 88 15. Respiratory Fungal Infections - p. 96 16. Rapid Diagnosis of Influenza - p. 104 17. Antiviral Resistance in Influenza Viruses - p. 113 18. Emerging Respiratory Viruses Other than Influenza - p. 126 19. Index - p. 139
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