Trusted by physicians and advanced practice providers through ten standard-setting editions, Fanaroff and Martin's Neonatal-Perinatal Medicine, 11th Edition, remains the reference of choice for expert, multidisciplinary guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. An expanded team of international authors, led by Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh of Rainbow Babies and Children's Hospital, brings you up to date with advances in the control of nosocomial infections in preterm infants, genetic disorders and birth defects, the fetal origins of adult disease, the late preterm infants, and much more – all designed to help you improve the quality of life and long-term outcomes of your patients.
1. Cover image - p. i 2. Title Page - p. i 3. Table of Contents - p. i 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. vii 7. Preface - p. xxi 8. Volume 1 - p. xxi 9. Part 1 The Field of Neonatal-Perinatal Medicine - p. xxi 10. 1 Growth of Neonatal Perinatal Medicine—A Historical Perspective - p. 2 11. 2 Epidemiology for Neonatologists - p. 18 12. 3 Medical Ethics in Neonatal Care - p. 25 13. 4 Legal Issues in Neonatal-Perinatal Medicine - p. 47 14. 5 Evaluating and Improving the Quality and Safety of Neonatal Intensive Care - p. 67 15. 6 Simulation and Debriefing in Neonatal-Perinatal Medicine - p. 102 16. 7 Practicing Evidence-Based Neonatal-Perinatal Medicine - p. 113 17. 8 Perinatal and Neonatal Care in Developing Countries - p. 120 18. 9 Social and Economic Contributors to Neonatal Outcome in the United States - p. 140 19. Part 2 The Fetus - p. 151 20. 10 Genetic Aspects of Perinatal Disease and Prenatal Diagnosis - p. 154 21. 11 Perinatal Ultrasound - p. 174 22. 12 Estimation of Fetal Well-Being - p. 210 23. 13 Surgical Treatment of the Fetus - p. 223 24. 14 Adverse Exposures to the Fetus and Neonate - p. 239 25. 15 Intrauterine Growth Restriction - p. 260 26. 16 Developmental Origins of Adult Health and Disease - p. 274 27. Part 3 Pregnancy Disorders and Their Impact on the Fetus - p. 285 28. 17 Hypertensive Disorders of Pregnancy - p. 288 29. 18 Pregnancy Complicated by Diabetes Mellitus - p. 304 30. 19 Obstetric Management of Prematurity - p. 312 31. 20 Fetal Effects of Autoimmune Disease - p. 346 32. 21 Obstetric Management of Multiple Gestation and Birth - p. 355 33. 22 Post-Term Pregnancy - p. 364 34. 23 Immune and Nonimmune Hydrops Fetalis - p. 371 35. 24 Amniotic Fluid Volume - p. 386 36. 25 Perinatal Infections and Chorioamnionitis - p. 404 37. 26 Placental Pathology - p. 415 38. Part 4 The Delivery Room - p. 422 39. 27 Anesthesia for Labor and Delivery - p. 424 40. 28 Physical Examination of the Newborn - p. 440 41. 29 Birth Injuries - p. 458 42. 30 Congenital Anomalies - p. 489 43. Part 5 Resuscitation of the Newborn - p. 513 44. 31 Overview and Initial Management of Delivery Room Resuscitation - p. 516 45. 32 Role of Positive Pressure Ventilation in Neonatal Resuscitation - p. 530 46. 33 Oxygen Therapy in Neonatal Resuscitation - p. 543 47. 34 Chest Compression, Medications, and Special Problems in Neonatal Resuscitation - p. 552 48. Part 6 The Physical Environment in Neonatal Care - p. 564 49. 35 Thermal Environment of the Intensive Care Nursery - p. 566 50. 36 Optimization of the NICU Environment - p. 577 51. Part 7 Provisions for Neonatal Care - p. 593 52. 37 Biomedical Engineering Aspects of Neonatal Cardiorespiratory Monitoring - p. 596 53. 38 Diagnostic Imaging of the Neonate - p. 608 54. 39 Anesthesia in the Neonate - p. 634 55. 40 The Late Preterm Infant - p. 654 56. 41 Nutrient Requirements/Nutritional Support in Premature Neonate - p. 670 57. 42 Support for the Family - p. 690 58. Part 8 Developmental Pharmacology - p. 702 59. 43 Principles of Drug Use in the Fetus and Neonate - p. 704 60. 44 Principles of Drug Use During Lactation - p. 717 61. 45 Pharmacokinetics in Neonatal Medicine - p. 734 62. 46 Infants of Substance-Using Mothers - p. 735 63. Part 9 The Immune System - p. 750 64. 47 Developmental Immunology - p. 752 65. 48 Postnatal Bacterial Infections - p. 789 66. 49 Fungal and Protozoal Infections of the Neonate - p. 809 67. 50 Viral Infections in the Neonate - p. 844 68. Herpesvirus Family - p. 845 69. Paramyxoviruses Family - p. 862 70. Human Immunodeficiency Virus - p. 869 71. Enteroviruses and Parechoviruses - p. 878 72. Hepatitis Viruses - p. 880 73. Rotavirus - p. 885 74. Parvovirus B19 - p. 887 75. Influenza A and B - p. 888 76. Rubella Virus - p. 891 77. Rhinovirus - p. 893 78. Coronavirus: Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome - p. 894 79. West Nile Virus - p. 895 80. Adenovirus - p. 896 81. Human Papillomavirus - p. 898 82. Emerging Viruses - p. 899 83. Acknowledgment - p. 902 84. References - p. 904 85. Part 10 The Central Nervous System - p. 911 86. 51 Normal and Abnormal Brain Development - p. 914 87. 52 White Matter Damage and Encephalopathy of Prematurity - p. 947 88. 53 Intracranial Hemorrhage and Vascular Lesions in the Neonate - p. 970 89. 54 Hypoxic–Ischemic Encephalopathy - p. 989 90. 55 Seizures in Neonates - p. 1015 91. 56 Hypotonia and Neuromuscular Disease in the Neonate - p. 1044 92. 57 Intracranial and Calvarial Disorders - p. 1060 93. 58 Spinal Dysraphisms - p. 1073 94. 59 Hearing Loss in the Newborn Infant - p. 1081 95. 60 Early Childhood Neurodevelopmental Outcomes of High-Risk Neonates - p. 1091 96. 61 The Role of Neonatal Neuroimaging in Predicting Neurodevelopmental Outcomes of Preterm Neonates - p. 1110 97. Volume 2 - p. 1122 98. Part 11 The Respiratory System - p. 1122 99. 62 Lung Development and Maturation - p. 1124 100. 63 Assessment of Neonatal Pulmonary Function - p. 1143 101. 64 Respiratory Distress Syndrome in the Neonate - p. 1159 102. 65 Assisted Ventilation of the Neonate and Its Complications - p. 1174 103. 66 Neonatal Respiratory Disorders - p. 1203 104. 67 Neonatal Apnea and the Foundation of Respiratory Control - p. 1231 105. 68 Upper Airway Lesions in the Neonate - p. 1244 106. 69 Bronchopulmonary Dysplasia in the Neonate - p. 1256 107. 70 Therapy for Cardiorespiratory Failure in the Neonate - p. 1270 108. Part 12 The Cardiovascular System - p. 1290 109. 71 Cardiac Embryology - p. 1292 110. 72 Pulmonary Vascular Development - p. 1306 111. 73 Prenatal Diagnosis of Congenital Heart Disease - p. 1320 112. 74 Patent Ductus Arteriosus - p. 1334 113. 75 Congenital Defects of the Cardiovascular System - p. 1342 114. 76 Cardiovascular Problems of the Neonate - p. 1364 115. 77 Disorders of Cardiac Rhythm and Conduction in Newborns - p. 1375 116. 78 Neonatal Management of Congenital Heart Disease - p. 1393 117. Part 13 The Blood and Hematopoietic System - p. 1414 118. 79 Hematologic and Oncologic Problems in the Fetus and Neonate - p. 1416 119. Human Hematopoietic Development - p. 1417 120. Red Blood Cells - p. 1416.e1 121. Red Blood Cell Disorders - p. 1422 122. White Blood Cells - p. 1443 123. The Hemostatic System - p. 1453 124. Neonatal Platelet Disorders - p. 1456 125. Neonatal Coagulation Disorders - p. 1461 126. Neonatal Thrombotic Disorders - p. 1465 127. Neoplasms in the Neonate - p. 1468 128. Acknowledgments - p. 1471 129. References - p. 1472 130. 80 Blood Component Therapy for the Neonate - p. 1476 131. Part 14 The Gastrointestinal Tract - p. 1503 132. 81 Development of the Neonatal Gastrointestinal Tract - p. 1506 133. 82 Gastrointestinal Reflux and Motility in the Neonate - p. 1513 134. 83 Disorders of Digestion in the Neonate - p. 1522 135. 84 Selected Gastrointestinal Anomalies in the Neonate - p. 1541 136. 85 Neonatal Necrotizing Enterocolitis - p. 1571 137. Part 15 Metabolic and Endocrine Disorders - p. 1581 138. 86 Disorders of Carbohydrate Metabolism in the Neonate - p. 1584 139. 87 Disorders of Calcium, Phosphorus, and Magnesium Metabolism in the Neonate - p. 1611 140. 88 Thyroid Disorders in the Neonate - p. 1643 141. 89 Disorders of Sex Development - p. 1665 142. 90 Inborn Errors of Metabolism - p. 1706 143. Common Misconceptions - p. 1707 144. Prospective Approaches - p. 1708 145. The Abnormal Newborn Infant: Clinical Phenotypes - p. 1728 146. The Abnormal Newborn Infant: Laboratory Phenotypes - p. 1749 147. Treatment - p. 1779 148. Conclusion - p. 1781 149. References - p. 1782 150. Part 16 Neonatal Jaundice and Liver Disease - p. 1785 151. 91 Neonatal Jaundice and Liver Diseases - p. 1788 152. Bilirubin Metabolism - p. 1789 153. “Conjugated” versus “Direct” Bilirubin - p. 1791 154. Equilibrium Between Bilirubin Production and Elimination Processes—The Major Determinant of TB Levels - p. 1792 155. Genetic Control of Bilirubin Production - p. 1794 156. Genetic Control of Uptake of Bilirubin into the Hepatocyte - p. 1795 157. Co-expression of Genes Modulating the Risk of Neonatal Hyperbilirubinemia - p. 1795 158. Bilirubin-Induced Neurologic Dysfunction (BIND) - p. 1815 159. Newer Methods of Diagnosis - p. 1821 160. Hyperbilirubinemia in Resource-Limited Countries - p. 1833 161. Conjugated Hyperbilirubinemia - p. 1834 162. References - p. 1845 163. Part 17 The Kidney and Urinary Tract - p. 1852 164. 92 Fluid, Electrolytes, and Acid-Base Homeostasis - p. 1854 165. 93 The Kidney and Urinary Tract of the Neonate - p. 1871 166. Part 18 The Skin - p. 1895 167. 94 The Skin of the Neonate - p. 1898 168. Part 19 The Eye - p. 1932 169. 95 Examination and Common Problems in the Neonatal Eye - p. 1934 170. 96 Retinopathy of Prematurity - p. 1970 171. Part 20 Neonatal Orthopedics - p. 1978 172. 97 Musculoskeletal Disorders in Neonates - p. 1980 173. 98 Bone and Joint Infections in Neonates - p. 1989 174. 99 Congenital Abnormalities of the Upper and Lower Extremities and Spine - p. 1995 175. Appendices - p. 2015 176. Appendix A Therapeutic Agents - p. 2018 177. Appendix B Tables of Normal Values - p. 2028 178. Appendix C Schedule for Immunization of Preterm Infants - p. 2067 179. Index - p. I1
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Trusted by physicians and advanced practice providers through ten standard-setting editions, Fanaroff and Martin's Neonatal-Perinatal Medicine, 11th Edition, remains the reference of choice for expert, multidisciplinary guidance on the management and evidence-based treatment of problems in the mother, fetus, and neonate. An expanded team of international authors, led by Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh of Rainbow Babies and Children's Hospital, brings you up to date with advances in the control of nosocomial infections in preterm infants, genetic disorders and birth defects, the fetal origins of adult disease, the late preterm infants, and much more – all designed to help you improve the quality of life and long-term outcomes of your patients.
1. Cover image - p. i 2. Title Page - p. i 3. Table of Contents - p. i 4. Copyright - p. iv 5. Dedication - p. v 6. Contributors - p. vii 7. Preface - p. xxi 8. Volume 1 - p. xxi 9. Part 1 The Field of Neonatal-Perinatal Medicine - p. xxi 10. 1 Growth of Neonatal Perinatal Medicine—A Historical Perspective - p. 2 11. 2 Epidemiology for Neonatologists - p. 18 12. 3 Medical Ethics in Neonatal Care - p. 25 13. 4 Legal Issues in Neonatal-Perinatal Medicine - p. 47 14. 5 Evaluating and Improving the Quality and Safety of Neonatal Intensive Care - p. 67 15. 6 Simulation and Debriefing in Neonatal-Perinatal Medicine - p. 102 16. 7 Practicing Evidence-Based Neonatal-Perinatal Medicine - p. 113 17. 8 Perinatal and Neonatal Care in Developing Countries - p. 120 18. 9 Social and Economic Contributors to Neonatal Outcome in the United States - p. 140 19. Part 2 The Fetus - p. 151 20. 10 Genetic Aspects of Perinatal Disease and Prenatal Diagnosis - p. 154 21. 11 Perinatal Ultrasound - p. 174 22. 12 Estimation of Fetal Well-Being - p. 210 23. 13 Surgical Treatment of the Fetus - p. 223 24. 14 Adverse Exposures to the Fetus and Neonate - p. 239 25. 15 Intrauterine Growth Restriction - p. 260 26. 16 Developmental Origins of Adult Health and Disease - p. 274 27. Part 3 Pregnancy Disorders and Their Impact on the Fetus - p. 285 28. 17 Hypertensive Disorders of Pregnancy - p. 288 29. 18 Pregnancy Complicated by Diabetes Mellitus - p. 304 30. 19 Obstetric Management of Prematurity - p. 312 31. 20 Fetal Effects of Autoimmune Disease - p. 346 32. 21 Obstetric Management of Multiple Gestation and Birth - p. 355 33. 22 Post-Term Pregnancy - p. 364 34. 23 Immune and Nonimmune Hydrops Fetalis - p. 371 35. 24 Amniotic Fluid Volume - p. 386 36. 25 Perinatal Infections and Chorioamnionitis - p. 404 37. 26 Placental Pathology - p. 415 38. Part 4 The Delivery Room - p. 422 39. 27 Anesthesia for Labor and Delivery - p. 424 40. 28 Physical Examination of the Newborn - p. 440 41. 29 Birth Injuries - p. 458 42. 30 Congenital Anomalies - p. 489 43. Part 5 Resuscitation of the Newborn - p. 513 44. 31 Overview and Initial Management of Delivery Room Resuscitation - p. 516 45. 32 Role of Positive Pressure Ventilation in Neonatal Resuscitation - p. 530 46. 33 Oxygen Therapy in Neonatal Resuscitation - p. 543 47. 34 Chest Compression, Medications, and Special Problems in Neonatal Resuscitation - p. 552 48. Part 6 The Physical Environment in Neonatal Care - p. 564 49. 35 Thermal Environment of the Intensive Care Nursery - p. 566 50. 36 Optimization of the NICU Environment - p. 577 51. Part 7 Provisions for Neonatal Care - p. 593 52. 37 Biomedical Engineering Aspects of Neonatal Cardiorespiratory Monitoring - p. 596 53. 38 Diagnostic Imaging of the Neonate - p. 608 54. 39 Anesthesia in the Neonate - p. 634 55. 40 The Late Preterm Infant - p. 654 56. 41 Nutrient Requirements/Nutritional Support in Premature Neonate - p. 670 57. 42 Support for the Family - p. 690 58. Part 8 Developmental Pharmacology - p. 702 59. 43 Principles of Drug Use in the Fetus and Neonate - p. 704 60. 44 Principles of Drug Use During Lactation - p. 717 61. 45 Pharmacokinetics in Neonatal Medicine - p. 734 62. 46 Infants of Substance-Using Mothers - p. 735 63. Part 9 The Immune System - p. 750 64. 47 Developmental Immunology - p. 752 65. 48 Postnatal Bacterial Infections - p. 789 66. 49 Fungal and Protozoal Infections of the Neonate - p. 809 67. 50 Viral Infections in the Neonate - p. 844 68. Herpesvirus Family - p. 845 69. Paramyxoviruses Family - p. 862 70. Human Immunodeficiency Virus - p. 869 71. Enteroviruses and Parechoviruses - p. 878 72. Hepatitis Viruses - p. 880 73. Rotavirus - p. 885 74. Parvovirus B19 - p. 887 75. Influenza A and B - p. 888 76. Rubella Virus - p. 891 77. Rhinovirus - p. 893 78. Coronavirus: Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome - p. 894 79. West Nile Virus - p. 895 80. Adenovirus - p. 896 81. Human Papillomavirus - p. 898 82. Emerging Viruses - p. 899 83. Acknowledgment - p. 902 84. References - p. 904 85. Part 10 The Central Nervous System - p. 911 86. 51 Normal and Abnormal Brain Development - p. 914 87. 52 White Matter Damage and Encephalopathy of Prematurity - p. 947 88. 53 Intracranial Hemorrhage and Vascular Lesions in the Neonate - p. 970 89. 54 Hypoxic–Ischemic Encephalopathy - p. 989 90. 55 Seizures in Neonates - p. 1015 91. 56 Hypotonia and Neuromuscular Disease in the Neonate - p. 1044 92. 57 Intracranial and Calvarial Disorders - p. 1060 93. 58 Spinal Dysraphisms - p. 1073 94. 59 Hearing Loss in the Newborn Infant - p. 1081 95. 60 Early Childhood Neurodevelopmental Outcomes of High-Risk Neonates - p. 1091 96. 61 The Role of Neonatal Neuroimaging in Predicting Neurodevelopmental Outcomes of Preterm Neonates - p. 1110 97. Volume 2 - p. 1122 98. Part 11 The Respiratory System - p. 1122 99. 62 Lung Development and Maturation - p. 1124 100. 63 Assessment of Neonatal Pulmonary Function - p. 1143 101. 64 Respiratory Distress Syndrome in the Neonate - p. 1159 102. 65 Assisted Ventilation of the Neonate and Its Complications - p. 1174 103. 66 Neonatal Respiratory Disorders - p. 1203 104. 67 Neonatal Apnea and the Foundation of Respiratory Control - p. 1231 105. 68 Upper Airway Lesions in the Neonate - p. 1244 106. 69 Bronchopulmonary Dysplasia in the Neonate - p. 1256 107. 70 Therapy for Cardiorespiratory Failure in the Neonate - p. 1270 108. Part 12 The Cardiovascular System - p. 1290 109. 71 Cardiac Embryology - p. 1292 110. 72 Pulmonary Vascular Development - p. 1306 111. 73 Prenatal Diagnosis of Congenital Heart Disease - p. 1320 112. 74 Patent Ductus Arteriosus - p. 1334 113. 75 Congenital Defects of the Cardiovascular System - p. 1342 114. 76 Cardiovascular Problems of the Neonate - p. 1364 115. 77 Disorders of Cardiac Rhythm and Conduction in Newborns - p. 1375 116. 78 Neonatal Management of Congenital Heart Disease - p. 1393 117. Part 13 The Blood and Hematopoietic System - p. 1414 118. 79 Hematologic and Oncologic Problems in the Fetus and Neonate - p. 1416 119. Human Hematopoietic Development - p. 1417 120. Red Blood Cells - p. 1416.e1 121. Red Blood Cell Disorders - p. 1422 122. White Blood Cells - p. 1443 123. The Hemostatic System - p. 1453 124. Neonatal Platelet Disorders - p. 1456 125. Neonatal Coagulation Disorders - p. 1461 126. Neonatal Thrombotic Disorders - p. 1465 127. Neoplasms in the Neonate - p. 1468 128. Acknowledgments - p. 1471 129. References - p. 1472 130. 80 Blood Component Therapy for the Neonate - p. 1476 131. Part 14 The Gastrointestinal Tract - p. 1503 132. 81 Development of the Neonatal Gastrointestinal Tract - p. 1506 133. 82 Gastrointestinal Reflux and Motility in the Neonate - p. 1513 134. 83 Disorders of Digestion in the Neonate - p. 1522 135. 84 Selected Gastrointestinal Anomalies in the Neonate - p. 1541 136. 85 Neonatal Necrotizing Enterocolitis - p. 1571 137. Part 15 Metabolic and Endocrine Disorders - p. 1581 138. 86 Disorders of Carbohydrate Metabolism in the Neonate - p. 1584 139. 87 Disorders of Calcium, Phosphorus, and Magnesium Metabolism in the Neonate - p. 1611 140. 88 Thyroid Disorders in the Neonate - p. 1643 141. 89 Disorders of Sex Development - p. 1665 142. 90 Inborn Errors of Metabolism - p. 1706 143. Common Misconceptions - p. 1707 144. Prospective Approaches - p. 1708 145. The Abnormal Newborn Infant: Clinical Phenotypes - p. 1728 146. The Abnormal Newborn Infant: Laboratory Phenotypes - p. 1749 147. Treatment - p. 1779 148. Conclusion - p. 1781 149. References - p. 1782 150. Part 16 Neonatal Jaundice and Liver Disease - p. 1785 151. 91 Neonatal Jaundice and Liver Diseases - p. 1788 152. Bilirubin Metabolism - p. 1789 153. “Conjugated” versus “Direct” Bilirubin - p. 1791 154. Equilibrium Between Bilirubin Production and Elimination Processes—The Major Determinant of TB Levels - p. 1792 155. Genetic Control of Bilirubin Production - p. 1794 156. Genetic Control of Uptake of Bilirubin into the Hepatocyte - p. 1795 157. Co-expression of Genes Modulating the Risk of Neonatal Hyperbilirubinemia - p. 1795 158. Bilirubin-Induced Neurologic Dysfunction (BIND) - p. 1815 159. Newer Methods of Diagnosis - p. 1821 160. Hyperbilirubinemia in Resource-Limited Countries - p. 1833 161. Conjugated Hyperbilirubinemia - p. 1834 162. References - p. 1845 163. Part 17 The Kidney and Urinary Tract - p. 1852 164. 92 Fluid, Electrolytes, and Acid-Base Homeostasis - p. 1854 165. 93 The Kidney and Urinary Tract of the Neonate - p. 1871 166. Part 18 The Skin - p. 1895 167. 94 The Skin of the Neonate - p. 1898 168. Part 19 The Eye - p. 1932 169. 95 Examination and Common Problems in the Neonatal Eye - p. 1934 170. 96 Retinopathy of Prematurity - p. 1970 171. Part 20 Neonatal Orthopedics - p. 1978 172. 97 Musculoskeletal Disorders in Neonates - p. 1980 173. 98 Bone and Joint Infections in Neonates - p. 1989 174. 99 Congenital Abnormalities of the Upper and Lower Extremities and Spine - p. 1995 175. Appendices - p. 2015 176. Appendix A Therapeutic Agents - p. 2018 177. Appendix B Tables of Normal Values - p. 2028 178. Appendix C Schedule for Immunization of Preterm Infants - p. 2067 179. Index - p. I1
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