Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The –Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance.
With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine.
1. Introduction: Human Genome Projects: The Omics Starting Point - p. xix 2. Chapter 1: Is the Classic Spermiogram Still Informative? How Did It Develop and Where Is It Going? - p. xxix 3. Chapter 2: Genetic Variations and Male Infertility - p. 19 4. Chapter 3: New Genetic Point Mutations in Male Infertility - p. 45 5. Chapter 4: Carrier Screening for Inherited Genetic Disorders: A Review of Current Practices - p. 62 6. Chapter 5: Telomeres in Germ Line and Early Embryo: An Overview - p. 75 7. Chapter 6: Human Protamine Genes’ Polymorphisms as a Possible Cause Underlying Male Infertility - p. 90 8. Chapter 7: Small RNAs Present in Semen and Their Role in Reproduction - p. 107 9. Chapter 8: Altered Transcriptomic Profiles Associated With Male Infertility - p. 123 10. Chapter 9: Proteomics and Metabolomics Studies and Clinical Outcomes - p. 145 11. Chapter 10: Epigenetics, Spermatogenesis, and Male Infertility - p. 170 12. Chapter 11: Changes in DNA Methylation Related to Male Infertility - p. 187 13. Chapter 12: Noninvasive Methods of Embryo Selection - p. 207 14. Chapter 13: Genetic Selection of the Human Embryos: From FISH to NGS, Past and Future - p. 225 15. Chapter 14: Unraveling the Causes of Failed Fertilization After Intracytoplasmic Sperm Injection Due to Oocyte Activation Deficiency - p. 242 16. Chapter 15: The Molecular Signature of the Endometrial Receptivity: Research and Clinical Application - p. 277 17. Chapter 16: The Acquisition of the Human Endometrial Receptivity Phenotype: Lessons From Proteomic Studies - p. 301 18. Chapter 17: Stem Cell-Derived Spermatozoa - p. 314 19. Chapter 18: Computational Approaches in Reproductomics - p. 345 20. Chapter 19: Conclusions—Year 2020: The “-Omics” Technologies and Personalized Assisted Reproduction - p. 383 21. Index - p. 391
Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The –Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance.
With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine.
1. Introduction: Human Genome Projects: The Omics Starting Point - p. xix 2. Chapter 1: Is the Classic Spermiogram Still Informative? How Did It Develop and Where Is It Going? - p. xxix 3. Chapter 2: Genetic Variations and Male Infertility - p. 19 4. Chapter 3: New Genetic Point Mutations in Male Infertility - p. 45 5. Chapter 4: Carrier Screening for Inherited Genetic Disorders: A Review of Current Practices - p. 62 6. Chapter 5: Telomeres in Germ Line and Early Embryo: An Overview - p. 75 7. Chapter 6: Human Protamine Genes’ Polymorphisms as a Possible Cause Underlying Male Infertility - p. 90 8. Chapter 7: Small RNAs Present in Semen and Their Role in Reproduction - p. 107 9. Chapter 8: Altered Transcriptomic Profiles Associated With Male Infertility - p. 123 10. Chapter 9: Proteomics and Metabolomics Studies and Clinical Outcomes - p. 145 11. Chapter 10: Epigenetics, Spermatogenesis, and Male Infertility - p. 170 12. Chapter 11: Changes in DNA Methylation Related to Male Infertility - p. 187 13. Chapter 12: Noninvasive Methods of Embryo Selection - p. 207 14. Chapter 13: Genetic Selection of the Human Embryos: From FISH to NGS, Past and Future - p. 225 15. Chapter 14: Unraveling the Causes of Failed Fertilization After Intracytoplasmic Sperm Injection Due to Oocyte Activation Deficiency - p. 242 16. Chapter 15: The Molecular Signature of the Endometrial Receptivity: Research and Clinical Application - p. 277 17. Chapter 16: The Acquisition of the Human Endometrial Receptivity Phenotype: Lessons From Proteomic Studies - p. 301 18. Chapter 17: Stem Cell-Derived Spermatozoa - p. 314 19. Chapter 18: Computational Approaches in Reproductomics - p. 345 20. Chapter 19: Conclusions—Year 2020: The “-Omics” Technologies and Personalized Assisted Reproduction - p. 383 21. Index - p. 391
